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The Cynomolgus Macaque MHC Polymorphism in Experimental Medicine
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- Takashi Shiina
- Department of Molecular Life Sciences, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan
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- Antoine Blancher
- Centre de Physiopathologie Toulouse-Purpan (CPTP), Université de Toulouse, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (Inserm), Université Paul Sabatier (UPS), 31000 Toulouse, France
Description
<jats:p>Among the non-human primates used in experimental medicine, cynomolgus macaques (Macaca fascicularis hereafter referred to as Mafa) are increasingly selected for the ease with which they are maintained and bred in captivity. Macaques belong to Old World monkeys and are phylogenetically much closer to humans than rodents, which are still the most frequently used animal model. Our understanding of the Mafa genome has progressed rapidly in recent years and has greatly benefited from the latest technical advances in molecular genetics. Cynomolgus macaques are widespread in Southeast Asia and numerous studies have shown a distinct genetic differentiation of continental and island populations. The major histocompatibility complex of cynomolgus macaque (Mafa MHC) is organized in the same way as that of human, but it differs from the latter by its high degree of classical class I gene duplication. Human polymorphic MHC regions play a pivotal role in allograft transplantation and have been associated with more than 100 diseases and/or phenotypes. The Mafa MHC polymorphism similarly plays a crucial role in experimental allografts of organs and stem cells. Experimental results show that the Mafa MHC class I and II regions influence the ability to mount an immune response against infectious pathogens and vaccines. MHC also affects cynomolgus macaque reproduction and impacts on numerous biological parameters. This review describes the Mafa MHC polymorphism and the methods currently used to characterize it. We discuss some of the major areas of experimental medicine where an effect induced by MHC polymorphism has been demonstrated.</jats:p>
Journal
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- Cells
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Cells 8 (9), 978-, 2019-08-26
MDPI AG
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Keywords
- [SDV.BA] Life Sciences [q-bio]/Animal biology
- [SDV.IMM] Life Sciences [q-bio]/Immunology
- [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics
- [SDV.BC]Life Sciences [q-bio]/Cellular Biology
- Review
- MHC polymorphism
- Major Histocompatibility Complex
- MESH: Major Histocompatibility Complex
- MESH: Macaca fascicularis / genetics
- Gene Duplication
- MESH: Polymorphism, Genetic
- MESH: Transplantation, Homologous
- Animals
- Transplantation, Homologous
- MESH: Animals
- MESH: Genome
- [SDV.BC] Life Sciences [q-bio]/Cellular Biology
- Genome
- Polymorphism, Genetic
- QH573-671
- [SDV.BA]Life Sciences [q-bio]/Animal biology
- MESH: Gene Duplication
- experimental medicine
- nonhuman primate models
- [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics
- Macaca fascicularis
- MESH: Models, Animal
- Models, Animal
- [SDV.IMM]Life Sciences [q-bio]/Immunology
- <i>Macaca fascicularis</i>
- Cytology
- cynomolgus macaque
Details 詳細情報について
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- CRID
- 1362539019082046464
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- ISSN
- 20734409
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- PubMed
- 31455025
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- Article Type
- journal article
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- Data Source
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- Crossref
- KAKEN
- OpenAIRE