{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544418328736640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/ejoc.201100163"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201100163"}},{"identifier":{"@type":"URI","@value":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/ejoc.201100163"}}],"dc:title":[{"@value":"Organocatalyzed Enantioselective Synthesis of Quaternary Carbon‐Containing Isoindolin‐1‐ones"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>3,3′‐Triphenylsilyl‐substituted (<jats:italic>S</jats:italic>)‐BINOL‐based (1,1′‐bi‐2‐naphthol) phosphoric acid has proven to be an effective organocatalyst for the asymmetric Friedel–Crafts alkylation of indoles with 3‐substituted 3‐hydroxyisoindolin‐1‐ones, affording the corresponding quaternary carbon‐containing 3,3‐disubstituted isoindolin‐1‐ones in good yields (up to 99 %) with good to excellent enantioselectivities (up to 95 % <jats:italic>ee</jats:italic>). The optical purity of the product was further improved after a single recrystallization. This protocol provides a convenient method for the catalytic asymmetric synthesis of valuable 3,3‐disubstituted isoindolin‐1‐ones in high yields and enantioselectivities.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544418328736643","@type":"Researcher","foaf:name":[{"@value":"Xiaolei Yu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418328736645","@type":"Researcher","foaf:name":[{"@value":"Youming Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418328736640","@type":"Researcher","foaf:name":[{"@value":"Guiping Wu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418328736644","@type":"Researcher","foaf:name":[{"@value":"Haibin Song"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418328736641","@type":"Researcher","foaf:name":[{"@value":"Zhenghong Zhou"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418328736642","@type":"Researcher","foaf:name":[{"@value":"Chuchi Tang"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1434193X"},{"@type":"EISSN","@value":"10990690"}],"prism:publicationName":[{"@value":"European Journal of Organic Chemistry"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2011-04-12","prism:volume":"2011","prism:number":"16","prism:startingPage":"3060","prism:endingPage":"3066"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fejoc.201100163"},{"@id":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/ejoc.201100163"}],"createdAt":"2011-04-12","modifiedAt":"2025-10-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050008389814559872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Enantioselective Aza-Friedel–Crafts Reaction of Indoles and Pyrroles Catalyzed by 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