{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544418360693248.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1182/blood-2006-08-038422"}},{"identifier":{"@type":"URI","@value":"http://ashpublications.org/blood/article-pdf/109/12/5371/1479183/zh801207005371.pdf"}}],"dc:title":[{"@value":"Functional specialization of human circulating CD16 and CD1c myeloid dendritic-cell subsets"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Human blood contains 2 populations of dendritic cells (DCs): plasmacytoid and myeloid (mDC). mDCs are subdivided into 3 subsets using the surface markers CD16, CD1c, and BDCA-3. Their role as pathogen sentinels and adjuvant targets was tested by phenotypic and functional analysis. We show that mDC subsets are immature and express mRNA for most toll-like receptors (TLRs), except for TLR3 in CD16-mDCs. The most represented subsets, CD16- and CD1c-mDCs, are similarly responsive to all TLR agonists. Among 31 cytokines tested, both subsets produce CXCL8 (IL-8)/tumor necrosis factor-α (TNF-α)/IL-6/CCL3 (MIP-1α)/CCL4 (MIP-1β)/IL-1β. CXCL8 (IL-8) is the predominant cytokine produced by CD1c-mDCs on TLR engagement, whereas all other cytokines, particularly TNF-α, are secreted in 10-fold to 100-fold higher amounts by CD16-mDCs. CD16-mDCs cocultured with human umbilical vein endothelial cells induce a significantly higher production of CXCL10 (IP-10), granulocyte-macrophage colony-stimulating factor, and granulocyte colony-stimulating factor than CD1c-mDCs. In addition, interleukin-3 and type I interferons are stimuli specifically for DC maturation rather than cytokine secretion, whereas TNF-α is almost ineffective in inducing either function, suggesting a mechanism of T-cell–DC crosstalk and of rapid induction of antigen-presenting cell function during viral infection rather than inflammation. In conclusion, CD16-mDCs show strong proinflammatory activity, whereas CD1c-mDCs appear to be mainly inducers of chemotaxis.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544418360693249","@type":"Researcher","foaf:name":[{"@value":"Diego Piccioli"}],"jpcoar:affiliationName":[{"@value":"Molecular Immunology Department, Research Center, Novartis Vaccines, Siena, Italy;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418360693252","@type":"Researcher","foaf:name":[{"@value":"Simona Tavarini"}],"jpcoar:affiliationName":[{"@value":"Molecular Immunology Department, Research Center, Novartis Vaccines, Siena, Italy;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418360693121","@type":"Researcher","foaf:name":[{"@value":"Erica Borgogni"}],"jpcoar:affiliationName":[{"@value":"Molecular Immunology Department, Research Center, Novartis Vaccines, Siena, Italy;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418360693120","@type":"Researcher","foaf:name":[{"@value":"Veronica Steri"}],"jpcoar:affiliationName":[{"@value":"Molecular Immunology Department, Research Center, Novartis Vaccines, Siena, Italy;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418360693250","@type":"Researcher","foaf:name":[{"@value":"Sandra Nuti"}],"jpcoar:affiliationName":[{"@value":"Molecular Immunology Department, Research Center, Novartis Vaccines, Siena, Italy;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418360693122","@type":"Researcher","foaf:name":[{"@value":"Chiara Sammicheli"}],"jpcoar:affiliationName":[{"@value":"Molecular Immunology Department, Research Center, Novartis Vaccines, Siena, Italy;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418360693253","@type":"Researcher","foaf:name":[{"@value":"Monia Bardelli"}],"jpcoar:affiliationName":[{"@value":"Molecular Biology Department, Università degli Studi, Siena, Italy;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418360693251","@type":"Researcher","foaf:name":[{"@value":"Daniela Montagna"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics, University of Pavia, Pediatric Hematology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418360693123","@type":"Researcher","foaf:name":[{"@value":"Franco Locatelli"}],"jpcoar:affiliationName":[{"@value":"Department of Pediatrics, University of Pavia, Pediatric Hematology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418360693248","@type":"Researcher","foaf:name":[{"@value":"Andreas Wack"}],"jpcoar:affiliationName":[{"@value":"Molecular Immunology Department, Research Center, Novartis Vaccines, Siena, Italy;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00064971"},{"@type":"EISSN","@value":"15280020"}],"prism:publicationName":[{"@value":"Blood"}],"dc:publisher":[{"@value":"American Society of Hematology"}],"prism:publicationDate":"2007-06-15","prism:volume":"109","prism:number":"12","prism:startingPage":"5371","prism:endingPage":"5379"},"reviewed":"false","url":[{"@id":"http://ashpublications.org/blood/article-pdf/109/12/5371/1479183/zh801207005371.pdf"}],"createdAt":"2007-03-02","modifiedAt":"2023-05-10","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002220913211904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Notch Ligand DLL4 Defines a Capability of Human Dendritic Cells in Regulating Th1 and Th17 Differentiation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118805675520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recent Progress in Dendritic Cell-Based Cancer Immunotherapy"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1182/blood-2006-08-038422"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.1501310_references_DOI_QnAWwyNWkrxAD2zBcW1Drc6X7sc"},{"@type":"CROSSREF","@value":"10.3390/cancers13102495_references_DOI_QnAWwyNWkrxAD2zBcW1Drc6X7sc"}]}