{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544418964744320.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.brainres.2005.11.028"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006899305016161?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006899305016161?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"16380096"}}],"dc:title":[{"@value":"Prenatal exposure to bisphenol A impairs sexual differentiation of exploratory behavior and increases depression-like behavior in rats"}],"description":[{"notation":[{"@value":"Perinatal exposure to bisphenol A (BPA, 0.1 and 1 ppm in drinking water applied to mother rats for 6 weeks) has been shown to impair the sexual differentiation in exploratory behavior, but the exact critical period of this disrupting effect is still unknown. In this study, we examined the effects of prenatal exposure to BPA (0.1 ppm in drinking water applied to dams during the final week of pregnant) on emotional and learning behaviors in addition to exploratory behavior. Estimated daily intake was 15 microg/kg/day, below the reference dose (RfD) in the United States and the daily tolerable intake (TDI) in Japan (50 microg/kg/day). The rats were successively tested in open-field test, elevated plus maze test, passive avoidance test and forced swimming test during development from 6 to 9 weeks of juvenile period. Prenatal exposure to BPA mainly affected male rats and abolished sex differences in rearing behavior in the open-field test and struggling behavior in the forced swimming test. BPA increased the immobility of male rats in the forced swimming test. The avoidance learning and behaviors in the elevated plus maze were not affected. The present study demonstrates that male rats at the final week of prenatal period are sensitive to BPA, which impairs sexual differentiation in rearing and struggling behavior and facilitate depression-like behavior."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544418964744320","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Fujimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418964744321","@type":"Researcher","foaf:name":[{"@value":"Kazuhiko Kubo"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544418964744322","@type":"Researcher","foaf:name":[{"@value":"Shuji Aou"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00068993"}],"prism:publicationName":[{"@value":"Brain Research"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2006-01","prism:volume":"1068","prism:number":"1","prism:startingPage":"49","prism:endingPage":"55"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006899305016161?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006899305016161?httpAccept=text/plain"}],"createdAt":"2005-12-28","modifiedAt":"2025-09-13","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Sex%20Differentiation","dc:title":"Sex Differentiation"},{"@id":"https://cir.nii.ac.jp/all?q=Behavior,%20Animal","dc:title":"Behavior, Animal"},{"@id":"https://cir.nii.ac.jp/all?q=Depression","dc:title":"Depression"},{"@id":"https://cir.nii.ac.jp/all?q=Anxiety","dc:title":"Anxiety"},{"@id":"https://cir.nii.ac.jp/all?q=Motor%20Activity","dc:title":"Motor Activity"},{"@id":"https://cir.nii.ac.jp/all?q=Rats","dc:title":"Rats"},{"@id":"https://cir.nii.ac.jp/all?q=Phenols","dc:title":"Phenols"},{"@id":"https://cir.nii.ac.jp/all?q=Pregnancy","dc:title":"Pregnancy"},{"@id":"https://cir.nii.ac.jp/all?q=Avoidance%20Learning","dc:title":"Avoidance Learning"},{"@id":"https://cir.nii.ac.jp/all?q=Exploratory%20Behavior","dc:title":"Exploratory Behavior"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Estrogens,%20Non-Steroidal","dc:title":"Estrogens, Non-Steroidal"},{"@id":"https://cir.nii.ac.jp/all?q=Benzhydryl%20Compounds","dc:title":"Benzhydryl Compounds"},{"@id":"https://cir.nii.ac.jp/all?q=Rats,%20Wistar","dc:title":"Rats, Wistar"},{"@id":"https://cir.nii.ac.jp/all?q=Swimming","dc:title":"Swimming"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004234228939776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurotoxicity of Endocrine Disruptors: Possible Involvement in Brain Development and Neurodegeneration"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691047182848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nanomolar dose of bisphenol A rapidly modulates spinogenesis in adult hippocampal neurons"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565165867811584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bisphenol A induces a rapid activation of Erk1/2 through GPR30 in human breast cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565166136011520","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Rat hyperactivity by bisphenol A, but not by its derivatives, 3-hydroxybisphenol A or bisphenol A 3,4-quinone"}]},{"@id":"https://cir.nii.ac.jp/crid/1360566393603137024","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Long-term study of urinary bisphenol A in elementary school children"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182513916032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846641111873920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Newborn mice exposed prenatally to bisphenol A show hyperactivity and defective neocortical development"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657334940160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Altered social interactions in male juvenile cynomolgus monkeys prenatally exposed to bisphenol A"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204902768768","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Low-dose effects of bisphenol A: a serious threat to human health?"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204904701056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prenatal low-dose bisphenol A enhances behavioral responses induced by a predator odor"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204905014656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Postnatal exposure to low-dose bisphenol A influences various emotional conditions"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205180660736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Perinatal Exposure to Low-Dose Bisphenol A Impairs Spatial Learning and Memory in Male Rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001288065548032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prenatal bisphenol A exposure is associated with medial amygdala neuron hyperresponsiveness to predator odor in rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679474733824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Quantitative Analyses of Inhibitory Effects of Bisphenol A on Neural Stem-cell Migration Using a Neurosphere Assay in vitro"}]},{"@id":"https://cir.nii.ac.jp/crid/1390848647561176320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Prenatal and postnatal bisphenol A exposure inhibits postnatal neurogenesis in the hippocampal dentate gyrus"}]},{"@id":"https://cir.nii.ac.jp/crid/1390858608264905088","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Exposure to bisphenol A or its phenolic analogs during early life induces different types of anxiety-like behaviors after maturity in male mice"}]},{"@id":"https://cir.nii.ac.jp/crid/2050870367059425536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Does the prenatal bisphenol A exposure alter DNA methylation levels in the mouse hippocampus？ : an analysis using a high-sensitivity methylome technique"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.brainres.2005.11.028"},{"@type":"OPENAIRE","@value":"doi_dedup___::9ca3af93bb4d3418c68d0139effa9c53"},{"@type":"CROSSREF","@value":"10.1080/10937404.2011.578557_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.2131/jts.43.531_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1254/jphs.13093fp_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.2131/jts.38.539_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.2131/jts.45.639_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1007/s12199-008-0049-6_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.2131/jts.33.389_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1016/j.tox.2014.06.009_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1186/s41021-018-0099-y_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1248/jhs.56.175_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.2131/jts.48.211_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1016/j.toxlet.2011.08.011_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1016/j.mce.2012.01.008_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1016/j.envpol.2010.09.004_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1016/j.yhbeh.2013.03.016_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.2131/jts.40.569_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"},{"@type":"CROSSREF","@value":"10.1016/j.ntt.2014.05.004_references_DOI_LBt4gYaw1PIEKRyy9LMRzjr3tl0"}]}