{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544419008250752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1006/bbrc.2001.5355"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X01953550?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0006291X01953550?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"11485328"}}],"dc:title":[{"@value":"A Critical Role for Syk in Endothelial Cell Proliferation and Migration"}],"description":[{"notation":[{"@value":"Syk is a protein-tyrosine kinase that is widely expressed in haematopoietic cells and involved in coupling activated immunoreceptors to downstream signaling. On the other hand, Syk-deficient mice showed severe petechiae in utero and died shortly after birth. Recently we have shown the expression of Syk in endothelial cells and morphological defects of these cells in embryonic Syk-deficient mice. Here we report that both proliferation and migration of human umbilical vein endothelial cells were severely impaired by adenovirus-mediated expression of Syk dominant negative mutants. Furthermore, a close relationship between Syk kinase activity and extracellular signal-regulated kinase activation was suggested. Our results indicate that Syk plays a critical role in endothelial cell functions, including morphogenesis, cell growth, migration, and survival, and contributes to maintaining vascular integrity in vivo."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544419008250753","@type":"Researcher","foaf:name":[{"@value":"Ryoko Inatome"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419008250752","@type":"Researcher","foaf:name":[{"@value":"Shigeru Yanagi"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419008250755","@type":"Researcher","foaf:name":[{"@value":"Tomoko Takano"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419008250754","@type":"Researcher","foaf:name":[{"@value":"Hirohei Yamamura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0006291X"}],"prism:publicationName":[{"@value":"Biochemical and Biophysical Research Communications"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2001-08","prism:volume":"286","prism:number":"1","prism:startingPage":"195","prism:endingPage":"199"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0006291X01953550?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0006291X01953550?httpAccept=text/plain"}],"createdAt":"2002-09-16","modifiedAt":"2025-11-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Enzyme%20Precursors","dc:title":"Enzyme Precursors"},{"@id":"https://cir.nii.ac.jp/all?q=Intracellular%20Signaling%20Peptides%20and%20Proteins","dc:title":"Intracellular Signaling Peptides and Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Protein-Tyrosine%20Kinases","dc:title":"Protein-Tyrosine Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Up-Regulation","dc:title":"Up-Regulation"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme%20Activation","dc:title":"Enzyme Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Movement","dc:title":"Cell Movement"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Syk%20Kinase","dc:title":"Syk Kinase"},{"@id":"https://cir.nii.ac.jp/all?q=Endothelium,%20Vascular","dc:title":"Endothelium, Vascular"},{"@id":"https://cir.nii.ac.jp/all?q=Mitogen-Activated%20Protein%20Kinases","dc:title":"Mitogen-Activated Protein Kinases"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Division","dc:title":"Cell Division"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=Signal%20Transduction","dc:title":"Signal Transduction"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001205177534080","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Endothelin-1 Induces Contraction via a Syk-Mediated p38 Mitogen-Activated Protein Kinase Pathway in Rat Aortic Smooth Muscle"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680157017088","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cofilin Phosphorylation Mediates Proliferation in Response to Platelet-Derived Growth Factor-BB in Rat Aortic Smooth Muscle Cells"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1006/bbrc.2001.5355"},{"@type":"OPENAIRE","@value":"doi_dedup___::8a10ccf35fe18280342718f86b8c5e44"},{"@type":"CROSSREF","@value":"10.1254/jphs.fp0072354_references_DOI_YI8kJZgAz9iG5e4plnkH021eHr3"},{"@type":"CROSSREF","@value":"10.1254/jphs.fp0070039_references_DOI_YI8kJZgAz9iG5e4plnkH021eHr3"}]}