{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544419067910784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1080/152165401753366122"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1080%2F152165401753366122"}},{"identifier":{"@type":"URI","@value":"https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/152165401753366122"}}],"dc:title":[{"@value":"Signaling by the Respiratory Burst in Macrophages"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>During phagocytosis or stimulation with a wide variety of agents, macrophages and other phagocytic cells produce reactive oxygen species (ROS) through activation of a multicomponent NADPH oxidase. ROS production through related NADPH oxidases has recently been demonstrated in several other cell types. Furthermore, the physiological generation of ROS production has now been clearly implicated in activating signaling pathways resulting in a broad array of physiological responses from cell proliferation to gene expression and apoptosis. This brief review suggests that: 1) hydrogen peroxide and superoxide, but not the hydroxyl radical, function as second messengers; 2) antioxidant enzymes function in the “turn‐off” phase of signal transduction; 3) the chemistry of thiols is critical in redox signaling; and 4) the primary physiological role of the respiratory burst in macrophages may be in redox signaling rather than microbicidal activity.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380579929446330880","@type":"Researcher","foaf:name":[{"@value":"Henry Jay Forman"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579929446330881","@type":"Researcher","foaf:name":[{"@value":"Martine Torres"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"15216543"},{"@type":"EISSN","@value":"15216551"}],"prism:publicationName":[{"@value":"IUBMB Life"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2001-06","prism:volume":"51","prism:number":"6","prism:startingPage":"365","prism:endingPage":"371"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1080%2F152165401753366122"},{"@id":"https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/152165401753366122"}],"createdAt":"2002-07-26","modifiedAt":"2023-11-19","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360846645842328064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Cutting Edge: Critical Role of Intracellular Osteopontin in Antifungal Innate Immune Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/2051433316891189632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Effect of physicochemical character differences on the genotoxic potency of kaolin"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1080/152165401753366122"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.1002735_references_DOI_9Yaxn45MlGmtABj2CaG0p6jMtAo"},{"@type":"CROSSREF","@value":"10.1186/s41021-017-0075-y_references_DOI_9Yaxn45MlGmtABj2CaG0p6jMtAo"}]}