Cobalt‐Catalyzed Enantioselective Hydroboration/Cyclization of 1,7‐Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers
-
- Caizhi Wu
- Department of Chemistry National University of Singapore 3 Science Drive 3 Singapore 117543 Singapore
-
- Jiayu Liao
- Department of Chemistry National University of Singapore 3 Science Drive 3 Singapore 117543 Singapore
-
- Shaozhong Ge
- Department of Chemistry National University of Singapore 3 Science Drive 3 Singapore 117543 Singapore
説明
<jats:title>Abstract</jats:title><jats:p>An asymmetric cobalt‐catalyzed hydroboration/cyclization of 1,7‐enynes to synthesize chiral six‐membered N‐heterocyclic compounds was developed. A variety of aniline‐tethered 1,7‐enynes react with pinacolborane to afford the corresponding chiral boryl‐functionalized quinoline derivatives in high yields with high enantioselectivity. This cobalt‐catalyzed asymmetric cyclization of 1,7‐enyens provides a general approach to access a series of chiral quinoline derivatives containing quaternary stereocenters.</jats:p>
収録刊行物
-
- Angewandte Chemie International Edition
-
Angewandte Chemie International Edition 58 (26), 8882-8886, 2019-05-21
Wiley