{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544419209411968.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1242/jcs.01275"}},{"identifier":{"@type":"URI","@value":"http://journals.biologists.com/jcs/article-pdf/117/18/4055/1533239/4055.pdf"}}],"dc:title":[{"@value":"Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Protein folding in the mitochondria is assisted by nuclear-encoded compartment-specific chaperones but regulation of the expression of their encoding genes is poorly understood. We found that the mitochondrial matrix HSP70 and HSP60 chaperones, encoded by the Caenorhabditis elegans hsp-6 and hsp-60 genes, were selectively activated by perturbations that impair assembly of multi-subunit mitochondrial complexes or by RNAi of genes encoding mitochondrial chaperones or proteases, which lead to defective protein folding and processing in the organelle. hsp-6 and hsp-60 induction was specific to perturbed mitochondrial protein handling, as neither heat-shock nor endoplasmic reticulum stress nor manipulations that impair mitochondrial steps in intermediary metabolism or ATP synthesis activated the mitochondrial chaperone genes. These observations support the existence of a mitochondrial unfolded protein response that couples mitochondrial chaperone gene expression to changes in the protein handling environment in the organelle.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544419209411970","@type":"Researcher","foaf:name":[{"@value":"Takunari Yoneda"}],"jpcoar:affiliationName":[{"@value":"Skirball Institute of Biomolecular Medicine and the Departments of Cell Biology and Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419209411969","@type":"Researcher","foaf:name":[{"@value":"Cristina Benedetti"}],"jpcoar:affiliationName":[{"@value":"Skirball Institute of Biomolecular Medicine and the Departments of Cell Biology and Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419209411972","@type":"Researcher","foaf:name":[{"@value":"Fumihiko Urano"}],"jpcoar:affiliationName":[{"@value":"Skirball Institute of Biomolecular Medicine and the Departments of Cell Biology and Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419209411968","@type":"Researcher","foaf:name":[{"@value":"Scott G. Clark"}],"jpcoar:affiliationName":[{"@value":"Skirball Institute of Biomolecular Medicine and the Departments of Cell Biology and Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419209411971","@type":"Researcher","foaf:name":[{"@value":"Heather P. Harding"}],"jpcoar:affiliationName":[{"@value":"Skirball Institute of Biomolecular Medicine and the Departments of Cell Biology and Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419209411973","@type":"Researcher","foaf:name":[{"@value":"David Ron"}],"jpcoar:affiliationName":[{"@value":"Skirball Institute of Biomolecular Medicine and the Departments of Cell Biology and Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"14779137"},{"@type":"PISSN","@value":"00219533"}],"prism:publicationName":[{"@value":"Journal of Cell Science"}],"dc:publisher":[{"@value":"The Company of Biologists"}],"prism:publicationDate":"2004-08-15","prism:volume":"117","prism:number":"18","prism:startingPage":"4055","prism:endingPage":"4066"},"reviewed":"false","url":[{"@id":"http://journals.biologists.com/jcs/article-pdf/117/18/4055/1533239/4055.pdf"}],"createdAt":"2004-07-28","modifiedAt":"2021-04-26","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001337459181056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Mitochondrial ​SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced ​HSF1 transcriptional activity"},{"@value":"Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282225476352","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Increased mitochondrial Ca\n                    <sup>2+</sup>\n                    contributes to health decline with age and Duchene muscular dystrophy in\n                    <i>C. elegans</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707290861440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Deleterious effects of mitochondrial ROS generated by KillerRed photodynamic action in human cell lines and C. elegans"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617661979264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118726592768","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Perspective on the Potential Involvement of Impaired Proteostasis in Neuropsychiatric Disorders"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660923535104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Asymmetric Arginine Dimethylation Modulates Mitochondrial Energy Metabolism and Homeostasis in <i>Caenorhabditis elegans</i>"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1242/jcs.01275"},{"@type":"CROSSREF","@value":"10.1096/fj.202201489rr_references_DOI_OX59Th2Uzg3qQslYuOHHnxQ719F"},{"@type":"CROSSREF","@value":"10.1002/2211-5463.12863_references_DOI_OX59Th2Uzg3qQslYuOHHnxQ719F"},{"@type":"CROSSREF","@value":"10.1038/ncomms7580_references_DOI_OX59Th2Uzg3qQslYuOHHnxQ719F"},{"@type":"CROSSREF","@value":"10.1016/j.jphotobiol.2012.08.005_references_DOI_OX59Th2Uzg3qQslYuOHHnxQ719F"},{"@type":"CROSSREF","@value":"10.1016/j.biopsych.2021.09.001_references_DOI_OX59Th2Uzg3qQslYuOHHnxQ719F"},{"@type":"CROSSREF","@value":"10.1128/mcb.00504-16_references_DOI_OX59Th2Uzg3qQslYuOHHnxQ719F"}]}