{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544419638059776.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1097/01.fjc.0000197539.12685.f5"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/10.1097/01.fjc.0000197539.12685.f5"}},{"identifier":{"@type":"PMID","@value":"16424797"}},{"identifier":{"@type":"NAID","@value":"80017680985"}}],"dc:title":[{"@value":"Inhibitory Effect of Efonidipine on Aldosterone Synthesis and Secretion in Human Adrenocarcinoma (H295R) Cells"}],"description":[{"notation":[{"@value":"Targeting aldosterone synthesis and/or release represents a potentially useful approach to the prevention of cardiovascular disease. Aldosterone production is stimulated by angiotensin II (Ang II) or extracellular K+ and is mediated mainly by Ca2+ influx into adrenal glomerulosa cells through T-type calcium channels. We therefore examined the effects of efonidipine, a dual T-type/L-type Ca2+ channel blocker, on aldosterone secretion in the H295R human adrenocarcinoma cell line; 100 nmol/L Ang II and 10 mmol/L K+ respectively increased aldosterone secretion from H295R cells 12-fold and 9-fold over baseline. Efonidipine dose-dependently inhibited both Ang II- and K+-induced aldosterone secretion, and nifedipine, an L-type Ca2+ channel blocker, and mibefradil, a relatively selective T-type channel blocker, similarly inhibited Ang II- and K+-induced aldosterone secretion, but were much less potent than efonidipine. Efonidipine also lowered cortisol secretion most potently among these drugs. Notably, efonidipine and mibefradil also significantly suppressed Ang II- and K+-induced mRNA expression of 11-beta-hydroxylase and aldosterone synthase, which catalyze the final two steps in the aldosterone synthesis, whereas nifedipine reduced only K+-induced enzyme expression. These findings suggest that efonidipine acts via T-type Ca2+ channel blockade to significantly reduce aldosterone secretion, and that this effect is mediated, at least in part, by suppression of 11-beta-hydroxylase and aldosterone synthase expression."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544419638059781","@type":"Researcher","foaf:name":[{"@value":"Keiichi Imagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419638059779","@type":"Researcher","foaf:name":[{"@value":"Satoshi Okayama"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419638059776","@type":"Researcher","foaf:name":[{"@value":"Minoru Takaoka"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419638059777","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Kawata"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419638059780","@type":"Researcher","foaf:name":[{"@value":"Noriyuki Naya"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419638059904","@type":"Researcher","foaf:name":[{"@value":"Tamio Nakajima"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419638059905","@type":"Researcher","foaf:name":[{"@value":"Manabu Horii"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419638059778","@type":"Researcher","foaf:name":[{"@value":"Shiro Uemura"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419638059782","@type":"Researcher","foaf:name":[{"@value":"Yoshihiko Saito"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01602446"}],"prism:publicationName":[{"@value":"Journal of Cardiovascular Pharmacology"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2006-01","prism:volume":"47","prism:number":"1","prism:startingPage":"133","prism:endingPage":"138"},"reviewed":"false","url":[{"@id":"https://journals.lww.com/10.1097/01.fjc.0000197539.12685.f5"}],"createdAt":"2006-01-19","modifiedAt":"2025-01-07","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Dihydropyridines","dc:title":"Dihydropyridines"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium%20Channels,%20L-Type","dc:title":"Calcium Channels, L-Type"},{"@id":"https://cir.nii.ac.jp/all?q=Adrenal%20Gland%20Neoplasms","dc:title":"Adrenal Gland Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium%20Channel%20Blockers","dc:title":"Calcium Channel Blockers"},{"@id":"https://cir.nii.ac.jp/all?q=Nitrophenols","dc:title":"Nitrophenols"},{"@id":"https://cir.nii.ac.jp/all?q=Calcium%20Channels,%20T-Type","dc:title":"Calcium Channels, T-Type"},{"@id":"https://cir.nii.ac.jp/all?q=Organophosphorus%20Compounds","dc:title":"Organophosphorus Compounds"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Cytochrome%20P-450%20CYP11B2","dc:title":"Cytochrome P-450 CYP11B2"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Messenger","dc:title":"RNA, Messenger"},{"@id":"https://cir.nii.ac.jp/all?q=Aldosterone","dc:title":"Aldosterone"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050013397240361344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Calcium channel blocker in patients with chronic kidney disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567187480841984","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"NCI-H295R, a Human Adrenal Cortex-Derived Cell Line, Expresses Purinergic Receptors Linked to Ca2+-Mobilization/Influx and Cortisol Secretion"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679221424640","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Efonidipine, a Ca2+-Channel Blocker, Enhances the Production of Dehydroepiandrosterone Sulfate in NCI-H295R Human Adrenocortical Carcinoma Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679410272640","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protective Effects of Efonidipine, a T- and L-Type Calcium Channel Blocker, on Renal Function and Arterial Stiffness in Type 2 Diabetic Patients with Hypertension and Nephropathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680201152512","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Efonidipine, an L- and T-type Calcium Channel Blocker, on the Renin-Angiotensin-Aldosterone System in Chronic Hemodialysis Patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681269240960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Nutritional and Bromacological Studies of Food Factors Using In Vitro and In Vivo Disease Models  (2007's JSNFS Award for Excellence in Research)"},{"@language":"ja","@value":"病態モデルによる食品因子の作用に関する栄養学的・食理学的研究　　（平成１９年度日本栄養・食糧学会賞受賞）"},{"@value":"病態モデルによる食品因子の作用に関する栄養学的・食理学的研究(平成19年度日本栄養・食糧学会員受賞)"},{"@language":"ja-Kana","@value":"ビョウタイ モデル ニ ヨル ショクヒン インシ ノ サヨウ ニ カンスル エイヨウガクテキ ショクリガクテキ ケンキュウ ヘイセイ 19ネンド ニホン エイヨウ ショクリョウ ガッカイイン ジュショウ"},{"@value":"Nutritional and Bromacological Studies of Food Factors Using In Vitro and In Vivo Disease Models"}]},{"@id":"https://cir.nii.ac.jp/crid/1571417125465200896","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Efonidipine Reduces Proteinuria 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Volunteers"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668925278937984","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparison of the Effects of Efonidipine and Amlodipine on Aldosterone in Patients with Hypertension"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1097/01.fjc.0000197539.12685.f5"},{"@type":"CIA","@value":"80017680985"},{"@type":"OPENAIRE","@value":"doi_dedup___::33d783c4059ed1e73b4663562f2a1396"},{"@type":"CROSSREF","@value":"10.1007/s10157-021-02153-1_references_DOI_6bW1jz89st7OrBOwBUPH0l3ib6N"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0071022_references_DOI_6bW1jz89st7OrBOwBUPH0l3ib6N"},{"@type":"CROSSREF","@value":"10.1620/tjem.224.263_references_DOI_6bW1jz89st7OrBOwBUPH0l3ib6N"},{"@type":"CROSSREF","@value":"10.1536/ihj.51.188_references_DOI_6bW1jz89st7OrBOwBUPH0l3ib6N"},{"@type":"CROSSREF","@value":"10.5551/jat.1628_references_DOI_6bW1jz89st7OrBOwBUPH0l3ib6N"}]}