{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544419640890880.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.0001-6349.2004.00602.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.0001-6349.2004.00602.x"}},{"identifier":{"@type":"URI","@value":"https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/j.0001-6349.2004.00602.x"}}],"dc:title":[{"@value":"Restricted fetal growth in sudden intrauterine unexplained death"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p><jats:bold>Background. </jats:bold> Unexplained antepartum stillbirth is a common cause of perinatal death, and identifying the fetus at risk is a challenge for obstetric practice. Intrauterine growth restriction (IUGR) is associated with a variety of adverse perinatal outcomes, but reports on its impact on unexplained stillbirths by population‐based birthweight standards have been varying, including both unexplained and unexplored stillbirths.</jats:p><jats:p><jats:bold>Aim. </jats:bold> We have studied IUGR, assessed by individually adjusted fetal weight standards, in antepartum deaths that remained unexplained despite thorough postmortem investigations.</jats:p><jats:p><jats:bold>Methods. </jats:bold> Antenatal health cards from a complete population‐based 10‐year material of 76 validated sudden intrauterine unexplained deaths were compared to those of 582 randomly selected liveborn controls. Birthweight <10th percentile of the individualized standard adjusted for gestational age, maternal height, weight, parity, ethnicity, and fetal gender was defined as growth restriction.</jats:p><jats:p><jats:bold>Results. </jats:bold> 52% of unexplained stillbirths were growth restricted, with a mean gestational age at death of 35.1 weeks. Suboptimal growth was the most important fetal determinant for sudden intrauterine unexplained death (odds ratio 7.0, 95% confidence interval 3.3–15.1). Concurrent maternal overweight or obesity, high age, and low education further increase the risk. Overweight and obesity increase the risk irrespective of fetal growth, and while high maternal age increases the risk of the normal weight fetus, it is not associated to growth restriction as a precursor of sudden intrauterine unexplained death.</jats:p><jats:p><jats:bold>Conclusions. </jats:bold> IUGR is an important risk factor of sudden intrauterine unexplained death, and this should be excluded in pregnancies with any other risk factor for sudden intrauterine unexplained death.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544419640890882","@type":"Researcher","foaf:name":[{"@value":"J. Frederik Frøen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419640890883","@type":"Researcher","foaf:name":[{"@value":"Jason O. Gardosi"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419640890881","@type":"Researcher","foaf:name":[{"@value":"Anne Thurmann"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544419640890884","@type":"Researcher","foaf:name":[{"@value":"André Francis"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344885284736","@type":"Researcher","foaf:name":[{"@value":"Babill Stray‐Pedersen"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00016349"},{"@type":"EISSN","@value":"16000412"}],"prism:publicationName":[{"@value":"Acta Obstetricia et Gynecologica Scandinavica"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2004-08-17","prism:volume":"83","prism:number":"9","prism:startingPage":"801","prism:endingPage":"807"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.0001-6349.2004.00602.x"},{"@id":"https://obgyn.onlinelibrary.wiley.com/doi/pdf/10.1111/j.0001-6349.2004.00602.x"}],"createdAt":"2004-08-17","modifiedAt":"2023-10-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004232425107584","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Neurodevelopmental outcomes at 3 years old for infants with birth weights under 500 g"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565164589165824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Characterization of placenta‐specific microRNAs in fetal growth restriction pregnancy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565170866566784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of Nod1 Signaling Induces Fetal Growth Restriction and Death through Fetal and Maternal Vasculopathy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092465515008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"New era of trophoblast research: integrating morphological and molecular approaches"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092533847424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Establishment of a Novel Fetal Growth Restriction Model and Development of a Stem-Cell Therapy Using Umbilical Cord-Derived Mesenchymal Stromal Cells"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.0001-6349.2004.00602.x"},{"@type":"CROSSREF","@value":"10.1016/j.pedneo.2017.09.005_references_DOI_J4sXbmumnkklnWB6JWBkPYpcLSD"},{"@type":"CROSSREF","@value":"10.1002/pd.4045_references_DOI_J4sXbmumnkklnWB6JWBkPYpcLSD"},{"@type":"CROSSREF","@value":"10.4049/jimmunol.1500295_references_DOI_J4sXbmumnkklnWB6JWBkPYpcLSD"},{"@type":"CROSSREF","@value":"10.1093/humupd/dmaa020_references_DOI_J4sXbmumnkklnWB6JWBkPYpcLSD"},{"@type":"CROSSREF","@value":"10.3389/fncel.2020.00212_references_DOI_J4sXbmumnkklnWB6JWBkPYpcLSD"}]}