{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544420162486912.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.4137/bmi.s2209"}},{"identifier":{"@type":"URI","@value":"http://journals.sagepub.com/doi/pdf/10.4137/BMI.S2209"}},{"identifier":{"@type":"URI","@value":"http://journals.sagepub.com/doi/full-xml/10.4137/BMI.S2209"}},{"identifier":{"@type":"PMID","@value":"19652760"}}],"dc:title":[{"@value":"Breath Hydrogen Produced by Ingestion of Commercial Hydrogen Water and Milk"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec><jats:title>Objective</jats:title><jats:p> To compare how and to what extent ingestion of hydrogen water and milk increase breath hydrogen in adults. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> Five subjects without specific diseases, ingested distilled or hydrogen water and milk as a reference material that could increase breath hydrogen. Their end-alveolar breath hydrogen was measured. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> Ingestion of hydrogen water rapidly increased breath hydrogen to the maximal level of approximately 40 ppm 10–15 min after ingestion and thereafter rapidly decreased to the baseline level, whereas ingestion of the same amount of distilled water did not change breath hydrogen (p < 0.001). Ingestion of hydrogen water increased both hydrogen peaks and the area under the curve (AUC) of breath hydrogen in a dose-dependent manner. Ingestion of milk showed a delayed and sustained increase of breath hydrogen in subjects with milk intolerance for up to 540 min. Ingestion of hydrogen water produced breath hydrogen at AUC levels of 2 to 9 ppm hour, whereas milk increased breath hydrogen to AUC levels of 164 ppm hour for 540 min after drinking. </jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p> Hydrogen water caused a rapid increase in breath hydrogen in a dose-dependent manner; however, the rise in breath hydrogen was not sustained compared with milk. </jats:p></jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544420162486916","@type":"Researcher","foaf:name":[{"@value":"Akito Shimouchi"}],"jpcoar:affiliationName":[{"@value":"Department of Etiology and Pathogenesis, National Cardiovascular Center Research Institute, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420162486914","@type":"Researcher","foaf:name":[{"@value":"Kazutoshi Nose"}],"jpcoar:affiliationName":[{"@value":"Department of Etiology and Pathogenesis, National Cardiovascular Center Research Institute, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420162486913","@type":"Researcher","foaf:name":[{"@value":"Makoto Yamaguchi"}],"jpcoar:affiliationName":[{"@value":"Research Center of Health, Physical Fitness and Sports, Nagoya University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420162486912","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Ishiguro"}],"jpcoar:affiliationName":[{"@value":"Research Center of Health, Physical Fitness and Sports, Nagoya University, Japan."}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420162486915","@type":"Researcher","foaf:name":[{"@value":"Takaharu Kondo"}],"jpcoar:affiliationName":[{"@value":"Research Center of Health, Physical Fitness and Sports, Nagoya University, Japan."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"11772719"},{"@type":"EISSN","@value":"11772719"}],"prism:publicationName":[{"@value":"Biomarker Insights"}],"dc:publisher":[{"@value":"SAGE Publications"}],"prism:publicationDate":"2009-01","prism:volume":"4","prism:startingPage":"BMI.S2209"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://journals.sagepub.com/page/policies/text-and-data-mining-license"],"url":[{"@id":"http://journals.sagepub.com/doi/pdf/10.4137/BMI.S2209"},{"@id":"http://journals.sagepub.com/doi/full-xml/10.4137/BMI.S2209"}],"createdAt":"2017-11-07","modifiedAt":"2025-03-02","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=hydrogen%20water","dc:title":"hydrogen water"},{"@id":"https://cir.nii.ac.jp/all?q=colonic%20fermentation","dc:title":"colonic fermentation"},{"@id":"https://cir.nii.ac.jp/all?q=milk","dc:title":"milk"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine%20(General)","dc:title":"Medicine (General)"},{"@id":"https://cir.nii.ac.jp/all?q=R5-920","dc:title":"R5-920"},{"@id":"https://cir.nii.ac.jp/all?q=breath%20hydrogen","dc:title":"breath hydrogen"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360290617731633536","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hydrogen-producing milk to prevent reduction in tear stability in persons using visual display terminals"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617773880448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hydrogen-Generating Silica Material Prevents UVA-Ray-Induced Cellular Oxidative Stress, Cell Death, Collagen Loss and Melanogenesis in Human Cells and 3D Skin Equivalents"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298754848764928","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The On/Off History of Hydrogen in Medicine: Will the Interest Persist This Time Around?"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846639697307648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Estimation of Molecular Hydrogen Consumption in the Human Whole Body After the Ingestion of Hydrogen-Rich Water"}]},{"@id":"https://cir.nii.ac.jp/crid/1390573242524917376","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"[Review] Interaction of Hydrogen Gas Produced by          Intestinal Microbes from Nondigestible Saccharides and Prevention of          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