{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544420177668352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41598-018-36748-8"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-018-36748-8"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41598-018-36748-8.pdf"}}],"dc:title":[{"@value":"Characterization of a male specific region containing a candidate sex determining gene in Atlantic cod"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The genetic mechanisms determining sex in teleost fishes are highly variable and the master sex determining gene has only been identified in few species. Here we characterize a male-specific region of 9 kb on linkage group 11 in Atlantic cod (<jats:italic>Gadus morhua</jats:italic>) harboring a single gene named<jats:italic>zkY</jats:italic>for zinc knuckle on the Y chromosome. Diagnostic PCR test of phenotypically sexed males and females confirm the sex-specific nature of the Y-sequence. We identified twelve highly similar autosomal gene copies of<jats:italic>zkY</jats:italic>, of which eight code for proteins containing the zinc knuckle motif. 3D modeling suggests that the amino acid changes observed in six copies might influence the putative RNA-binding specificity. Cod zkY and the autosomal proteins zk1 and zk2 possess an identical zinc knuckle structure, but only the Y-specific gene<jats:italic>zkY</jats:italic>was expressed at high levels in the developing larvae before the onset of sex differentiation. Collectively these data suggest<jats:italic>zkY</jats:italic>as a candidate master masculinization gene in Atlantic cod. PCR amplification of Y-sequences in Arctic cod (<jats:italic>Arctogadus glacialis</jats:italic>) and Greenland cod (<jats:italic>Gadus macrocephalus ogac</jats:italic>) suggests that the male-specific region emerged in codfishes more than 7.5 million years ago.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544420177668353","@type":"Researcher","foaf:name":[{"@value":"Tina Graceline Kirubakaran"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420177668482","@type":"Researcher","foaf:name":[{"@value":"Øivind Andersen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420177668480","@type":"Researcher","foaf:name":[{"@value":"Maria Cristina De Rosa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420177668483","@type":"Researcher","foaf:name":[{"@value":"Terese Andersstuen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420177668352","@type":"Researcher","foaf:name":[{"@value":"Kristina Hallan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420177668354","@type":"Researcher","foaf:name":[{"@value":"Matthew Peter Kent"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420177668481","@type":"Researcher","foaf:name":[{"@value":"Sigbjørn Lien"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20452322"}],"prism:publicationName":[{"@value":"Scientific Reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2019-01-15","prism:volume":"9","prism:number":"1"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41598-018-36748-8"},{"@id":"https://www.nature.com/articles/s41598-018-36748-8.pdf"}],"createdAt":"2019-01-09","modifiedAt":"2023-09-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360022307166763648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"RADSex: a computational workflow to study sex determination using Restriction Site-Associated DNA Sequencing data"}]},{"@id":"https://cir.nii.ac.jp/crid/1360584339757342848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Diversity and Convergence of Sex-Determination Mechanisms in Teleost Fish"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/s41598-018-36748-8"},{"@type":"CROSSREF","@value":"10.1101/2020.04.22.054866_references_DOI_Hxs4wyMbebr7VMB1ceOTzhZQMQq"},{"@type":"CROSSREF","@value":"10.1146/annurev-animal-021122-113935_references_DOI_Hxs4wyMbebr7VMB1ceOTzhZQMQq"},{"@type":"CROSSREF","@value":"10.1111/1755-0998.13360_references_DOI_Hxs4wyMbebr7VMB1ceOTzhZQMQq"}]}