{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544420192847232.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/etc.34"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.34"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/etc/article-pdf/29/3/730/59858856/34.pdf"}}],"dc:title":[{"@value":"Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Ecological risk assessors face increasing demands to assess more chemicals, with greater speed and accuracy, and to do so using fewer resources and experimental animals. New approaches in biological and computational sciences may be able to generate mechanistic information that could help in meeting these challenges. However, to use mechanistic data to support chemical assessments, there is a need for effective translation of this information into endpoints meaningful to ecological risk—effects on survival, development, and reproduction in individual organisms and, by extension, impacts on populations. Here we discuss a framework designed for this purpose, the adverse outcome pathway (AOP). An AOP is a conceptual construct that portrays existing knowledge concerning the linkage between a direct molecular initiating event and an adverse outcome at a biological level of organization relevant to risk assessment. The practical utility of AOPs for ecological risk assessment of chemicals is illustrated using five case examples. The examples demonstrate how the AOP concept can focus toxicity testing in terms of species and endpoint selection, enhance across-chemical extrapolation, and support prediction of mixture effects. The examples also show how AOPs facilitate use of molecular or biochemical endpoints (sometimes referred to as biomarkers) for forecasting chemical impacts on individuals and populations. In the concluding sections of the paper, we discuss how AOPs can help to guide research that supports chemical risk assessments and advocate for the incorporation of this approach into a broader systems biology framework. Environ. Toxicol. Chem. 2010;29:730–741. © 2009 SETAC</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544420192847235","@type":"Researcher","foaf:name":[{"@value":"Gerald T. Ankley"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847107","@type":"Researcher","foaf:name":[{"@value":"Richard S. Bennett"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847106","@type":"Researcher","foaf:name":[{"@value":"Russell J. Erickson"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847110","@type":"Researcher","foaf:name":[{"@value":"Dale J. Hoff"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847105","@type":"Researcher","foaf:name":[{"@value":"Michael W. Hornung"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847233","@type":"Researcher","foaf:name":[{"@value":"Rodney D. Johnson"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847111","@type":"Researcher","foaf:name":[{"@value":"David R. Mount"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847104","@type":"Researcher","foaf:name":[{"@value":"John W. Nichols"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847108","@type":"Researcher","foaf:name":[{"@value":"Christine L. Russom"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847232","@type":"Researcher","foaf:name":[{"@value":"Patricia K. Schmieder"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847109","@type":"Researcher","foaf:name":[{"@value":"Jose A. Serrrano"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847112","@type":"Researcher","foaf:name":[{"@value":"Joseph E. Tietge"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420192847234","@type":"Researcher","foaf:name":[{"@value":"Daniel L. Villeneuve"}],"jpcoar:affiliationName":[{"@value":"U.S. Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid-Continent Ecology Division, 6201 Condon Boulevard, Duluth, Minnesota 55804"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07307268"},{"@type":"EISSN","@value":"15528618"}],"prism:publicationName":[{"@value":"Environmental Toxicology and Chemistry"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2009-11-09","prism:volume":"29","prism:number":"3","prism:startingPage":"730","prism:endingPage":"741"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights","http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fetc.34"},{"@id":"https://academic.oup.com/etc/article-pdf/29/3/730/59858856/34.pdf"}],"createdAt":"2010-03-16","modifiedAt":"2025-02-19","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050577232666939904","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Molecular and cellular basis of the dose-rate-dependent adverse effects of radiation exposure in animal models. 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Discovery"}]},{"@id":"https://cir.nii.ac.jp/crid/1390002184890375808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Challenge for Adverse Outcome Pathway (AOP)-based Chemical Safety Assessment"},{"@language":"ja","@value":"AOP (Adverse Outcome Pathway；有害性発現経路) に基づいた化学物質の安全性評価へ向けたチャレンジ"},{"@value":"Symposium Review : AOP (Adverse Outcome Pathway ; 有害性発現経路)に基づいた化学物質の安全性評価へ向けたチャレンジ"},{"@language":"ja-Kana","@value":"Symposium Review : AOP (Adverse Outcome Pathway ; ユウガイセイ ハツゲン ケイロ)ニ モトズイタ カガク ブッシツ ノ アンゼンセイ ヒョウカ エ ムケタ チャレンジ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390002184891165312","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transcriptomics-driven Evaluation on Liver Toxicity Using Adverse Outcome Pathways (AOP)"},{"@language":"ja","@value":"遺伝子発現量データを用いたAOPに基づく肝毒性評価の可能性"},{"@value":"Symposium Review 遺伝子発現量データを用いたAOPに基づく肝毒性評価の可能性"},{"@language":"ja-Kana","@value":"Symposium Review イデンシ ハツゲンリョウ データ オ モチイタ AOP ニ モトズク カン ドクセイ ヒョウカ ノ カノウセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390017345599741312","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Pathogenesis of chemically induced nasal cavity tumors in rodents:          contribution to adverse outcome pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679881333888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A category approach to predicting the hemolytic effects of ethylene glycol alkyl ethers in repeated-dose toxicity"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680334502144","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"EVALUATION OF TREATMENT PROCESS ON THE REDUCTION OF BIOLOGICAL EFFECT OF WASTEWATER WITH SELECTED GENE EXPRESSIONS FOR SEXUAL REPRODUCTION AND GROWTH IN MEDAKA"},{"@language":"ja","@value":"メダカの生殖・成長関連遺伝子群による下水処理過程の生物影響削減効果の評価"},{"@language":"ja-Kana","@value":"メダカ ノ セイショク ・ セイチョウ カンレン イデンシグン ニ ヨル ゲスイ ショリ カテイ ノ セイブツ エイキョウ サクゲン コウカ ノ ヒョウカ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681193964288","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"大規模副作用データベースと計算毒性学に基づく副作用予測"},{"@language":"en","@value":"Adverse Effect Predictions Based on Computational Toxicology Techniques and Large-scale Databases"},{"@value":"Symposium Review 大規模副作用データベースと計算毒性学に基づく副作用予測"},{"@language":"ja-Kana","@value":"Symposium Review ダイキボ フクサヨウ データベース ト ケイサン ドクセイガク ニ モトズク フクサヨウ ヨソク"}]},{"@id":"https://cir.nii.ac.jp/crid/1390290239003215872","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association between <i>in 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