{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544420288502016.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.1124550"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.1124550"}}],"dc:title":[{"@value":"Autophagic Fungal Cell Death Is Necessary for Infection by the Rice Blast Fungus"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    Rice blast is caused by the fungus\n                    <jats:italic>Magnaporthe grisea</jats:italic>\n                    , which elaborates specialized infection cells called appressoria to penetrate the tough outer cuticle of the rice plant\n                    <jats:italic>Oryza sativa</jats:italic>\n                    . We found that the formation of an appressorium required, sequentially, the completion of mitosis, nuclear migration, and death of the conidium (fungal spore) from which the infection originated. Genetic intervention during mitosis prevented both appressorium development and conidium death. Impairment of autophagy, by the targeted mutation of the\n                    <jats:italic>MgATG8</jats:italic>\n                    gene, arrested conidial cell death but rendered the fungus nonpathogenic. Thus, the initiation of rice blast requires autophagic cell death of the conidium.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544420288502019","@type":"Researcher","foaf:name":[{"@value":"Claire Veneault-Fourrey"}],"jpcoar:affiliationName":[{"@value":"School of Biosciences, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420288502016","@type":"Researcher","foaf:name":[{"@value":"Madhumita Barooah"}],"jpcoar:affiliationName":[{"@value":"School of Biosciences, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420288502020","@type":"Researcher","foaf:name":[{"@value":"Martin Egan"}],"jpcoar:affiliationName":[{"@value":"School of Biosciences, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420288502018","@type":"Researcher","foaf:name":[{"@value":"Gavin Wakley"}],"jpcoar:affiliationName":[{"@value":"School of Biosciences, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420288502017","@type":"Researcher","foaf:name":[{"@value":"Nicholas J. Talbot"}],"jpcoar:affiliationName":[{"@value":"School of Biosciences, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, UK."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"2006-04-28","prism:volume":"312","prism:number":"5773","prism:startingPage":"580","prism:endingPage":"583"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.1124550"}],"createdAt":"2006-04-27","modifiedAt":"2024-01-09","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282810697647744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Yeast Methylotrophy and Autophagy in a Methanol-Oscillating Environment on Growing 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