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When the microspheres were subjected to degradation in phosphate-buffered saline solution containing collagenase, the digestion of microspheres was found to decrease with increasing cross-linking. Interferon was incorporated in the microspheres at a high trapping efficiency, and the rate of interferon release from the microspheres was regulated by the extent of cross-linking with glutaraldehyde. Gelatin microspheres incorporating interferon-alpha were readily phagocytosed by macrophages, regardless of the extent of cross-linking, and the phagocytosed microspheres were observed to be degraded gradually in the interior of macrophages, resulting in the slow release of the incorporated interferon in the cells."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544420644874753","@type":"Researcher","foaf:name":[{"@value":"Yasuhiko Tabata"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420644874752","@type":"Researcher","foaf:name":[{"@value":"Yoshito Ikada"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"07248741"},{"@type":"EISSN","@value":"1573904X"}],"prism:publicationName":[{"@value":"Pharmaceutical Research"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"1989-05","prism:volume":"6","prism:number":"5","prism:startingPage":"422","prism:endingPage":"427"},"reviewed":"false","dc:rights":["https://www.springernature.com/gp/researchers/text-and-data-mining","https://www.springernature.com/gp/researchers/text-and-data-mining"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1023/A:1015991617704.pdf"},{"@id":"https://link.springer.com/article/10.1023/A:1015991617704/fulltext.html"}],"createdAt":"2002-12-28","modifiedAt":"2025-08-01","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Iodine%20Radioisotopes","dc:title":"Iodine Radioisotopes"},{"@id":"https://cir.nii.ac.jp/all?q=Time%20Factors","dc:title":"Time Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Phagocytosis","dc:title":"Phagocytosis"},{"@id":"https://cir.nii.ac.jp/all?q=Glutaral","dc:title":"Glutaral"},{"@id":"https://cir.nii.ac.jp/all?q=Chemistry,%20Pharmaceutical","dc:title":"Chemistry, Pharmaceutical"},{"@id":"https://cir.nii.ac.jp/all?q=Microscopy,%20Electron,%20Scanning","dc:title":"Microscopy, Electron, Scanning"},{"@id":"https://cir.nii.ac.jp/all?q=Gelatin","dc:title":"Gelatin"},{"@id":"https://cir.nii.ac.jp/all?q=Indicators%20and%20Reagents","dc:title":"Indicators and Reagents"},{"@id":"https://cir.nii.ac.jp/all?q=Interferons","dc:title":"Interferons"},{"@id":"https://cir.nii.ac.jp/all?q=Microspheres","dc:title":"Microspheres"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285707093165696","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Experimental proliferative vitreoretinopathy in rabbits by delivery of bioactive proteins with gelatin microspheres"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567180110840064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Osteogenic cellular activity around onlaid octacalcium phosphate‐gelatin composite onto rat calvaria"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092534350464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Tumor-targeting hyaluronic acid/fluorescent carborane complex for boron neutron capture therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679601633792","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Biodegradable Microspheres Based on Gelatin-Porcine Mucin Admixtures: in Vitro and in Vivo Delivery Studies"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231874537904512","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"新規免疫adjuvantとしてのゼラチンマイクロスフェアーの経口ワクチンへの応用"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1023/a:1015991617704"},{"@type":"CIA","@value":"30012328348"},{"@type":"OPENAIRE","@value":"pmid_dedup__::f0dcefdf82d3d6c844a9d2449335c469"},{"@type":"CROSSREF","@value":"10.1248/bpb.32.1754_references_DOI_5I83ex8A0hEMwWRl2BXIm5RKhi9"},{"@type":"CROSSREF","@value":"10.1016/j.ejpb.2018.06.013_references_DOI_5I83ex8A0hEMwWRl2BXIm5RKhi9"},{"@type":"CROSSREF","@value":"10.1002/jbm.a.36335_references_DOI_5I83ex8A0hEMwWRl2BXIm5RKhi9"},{"@type":"CROSSREF","@value":"10.1016/j.bbrc.2021.04.037_references_DOI_5I83ex8A0hEMwWRl2BXIm5RKhi9"}]}