{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544420817574144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.1607745113"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.1607745113"}}],"dc:title":[{"@value":"AKAP220 manages apical actin networks that coordinate aquaporin-2 location and renal water reabsorption"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Significance</jats:title>\n          <jats:p>Systemic control of water homeostasis is a vital physiological process. Vasopressin-regulated reabsorption of water through aquaporin-2 (AQP2) water pores in the kidney preserves fluid balance and results in more concentrated urine. We have discovered that the scaffolding protein A-Kinase Anchoring Protein 220 (AKAP220) controls vasopressin-independent aspects of AQP2 trafficking at apical membranes of cells of the kidney-collecting ducts. We postulate that this proceeds via a molecular mechanism that evokes RhoA-mediated modulation of “actin barrier” dynamics. Loss of AKAP220 leads to accumulation of AQP2 at the apical plasma membrane and reduces urine-diluting capacity during overhydration. This phenotype may be clinically relevant, as accumulation of AQP2 at the apical membrane is the desired therapeutic outcome when treating patients with certain renal disorders, including nephrogenic diabetes insipidus.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544420817574149","@type":"Researcher","foaf:name":[{"@value":"Jennifer L. Whiting"}],"jpcoar:affiliationName":[{"@value":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195;"},{"@value":"Department of Pharmacology, University of Washington, Seattle, WA 98195"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420817574145","@type":"Researcher","foaf:name":[{"@value":"Leah Ogier"}],"jpcoar:affiliationName":[{"@value":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195;"},{"@value":"Department of Pharmacology, University of Washington, Seattle, WA 98195"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420817574146","@type":"Researcher","foaf:name":[{"@value":"Katherine A. Forbush"}],"jpcoar:affiliationName":[{"@value":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195;"},{"@value":"Department of Pharmacology, University of Washington, Seattle, WA 98195"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420817574151","@type":"Researcher","foaf:name":[{"@value":"Paula Bucko"}],"jpcoar:affiliationName":[{"@value":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195;"},{"@value":"Department of Pharmacology, University of Washington, Seattle, WA 98195"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420817574147","@type":"Researcher","foaf:name":[{"@value":"Janani Gopalan"}],"jpcoar:affiliationName":[{"@value":"Department of Pharmacology, University of Washington, Seattle, WA 98195"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420817574150","@type":"Researcher","foaf:name":[{"@value":"Ole-Morten Seternes"}],"jpcoar:affiliationName":[{"@value":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195;"},{"@value":"Department of Pharmacology, University of Washington, Seattle, WA 98195"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420817574148","@type":"Researcher","foaf:name":[{"@value":"Lorene K. Langeberg"}],"jpcoar:affiliationName":[{"@value":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195;"},{"@value":"Department of Pharmacology, University of Washington, Seattle, WA 98195"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420817574144","@type":"Researcher","foaf:name":[{"@value":"John D. Scott"}],"jpcoar:affiliationName":[{"@value":"Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195;"},{"@value":"Department of Pharmacology, University of Washington, Seattle, WA 98195"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2016-07-11","prism:volume":"113","prism:number":"30","prism:startingPage":"E4328"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.1607745113"}],"createdAt":"2016-07-12","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360584339769316992","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"LRBA signalosomes activate vasopressin‐induced AQP2 trafficking at recycling endosomes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705598388608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of protein kinase A signalling molecules in renal collecting ducts"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861707121852672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"LRBA is essential for urinary concentration and body water homeostasis"}]},{"@id":"https://cir.nii.ac.jp/crid/2051151842055064064","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hydrochlorothiazide ameliorates polyuria caused by tolvaptan treatment of polycystic kidney disease in PCK rats"}]},{"@id":"https://cir.nii.ac.jp/crid/2051151842060103424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Activation of AQP2 water channels by protein kinase A : therapeutic strategies for congenital nephrogenic diabetes insipidus"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.1607745113"},{"@type":"CROSSREF","@value":"10.1113/jp285188_references_DOI_TOkFLIMJ80YsN6gtcTjpZJuY6zq"},{"@type":"CROSSREF","@value":"10.1007/s10157-018-1669-9_references_DOI_TOkFLIMJ80YsN6gtcTjpZJuY6zq"},{"@type":"CROSSREF","@value":"10.1007/s10157-021-02108-6_references_DOI_TOkFLIMJ80YsN6gtcTjpZJuY6zq"},{"@type":"CROSSREF","@value":"10.1113/jp284178_references_DOI_TOkFLIMJ80YsN6gtcTjpZJuY6zq"},{"@type":"CROSSREF","@value":"10.1073/pnas.2202125119_references_DOI_TOkFLIMJ80YsN6gtcTjpZJuY6zq"}]}