{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544420898144128.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/anie.201405401"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201405401"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201405401"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.201405401"}}],"dc:title":[{"@value":"Enantioselective CH Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:p>\n                    An asymmetric unactivated alkene/CH bond difunctionalization reaction for the concomitant construction of CCF\n                    <jats:sub>3</jats:sub>\n                    and CO bonds was realized by using a Cu/Brønsted acid cooperative catalytic system, thus providing facile access to valuable chiral CF\n                    <jats:sub>3</jats:sub>\n                    ‐containing N,O‐aminals with excellent regio‐, chemo‐, and enantioselectivity. Mechanistic studies revealed that this reaction may proceed by an unprecedented 1,5‐hydride shift involving activation of unactivated alkenes and a radical trifluoromethylation to initiate subsequent enantioselective functionalization of CH bonds. Control experiments also suggested that chiral Brønsted acid plays multiple roles and not only controls the stereoselectivity but also increases the reaction rate through activation of Togni’s reagent.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544420898144135","@type":"Researcher","foaf:name":[{"@value":"Peng Yu"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818313157505","@type":"Researcher","foaf:name":[{"@value":"Jin‐Shun Lin"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420898144132","@type":"Researcher","foaf:name":[{"@value":"Lei Li"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818313157504","@type":"Researcher","foaf:name":[{"@value":"Sheng‐Cai Zheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818313157506","@type":"Researcher","foaf:name":[{"@value":"Ya‐Ping Xiong"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818313157508","@type":"Researcher","foaf:name":[{"@value":"Li‐Jiao Zhao"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420898144133","@type":"Researcher","foaf:name":[{"@value":"Bin Tan"}]},{"@id":"https://cir.nii.ac.jp/crid/1380579818313157507","@type":"Researcher","foaf:name":[{"@value":"Xin‐Yuan Liu"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14337851"},{"@type":"EISSN","@value":"15213773"}],"prism:publicationName":[{"@value":"Angewandte Chemie International Edition"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2014-09-08","prism:volume":"53","prism:number":"44","prism:startingPage":"11890","prism:endingPage":"11894"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor","http://doi.wiley.com/10.1002/tdm_license_1.1"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fanie.201405401"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/anie.201405401"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/anie.201405401"}],"createdAt":"2014-09-08","modifiedAt":"2026-03-08","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360576118685897856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Palladium-Catalyzed Remote Diborylative Cyclization of Dienes with Diborons via Chain Walking"}]},{"@id":"https://cir.nii.ac.jp/crid/1360861705587639552","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Evolution and Future of Hetero‐ and Hydro‐Trifluoromethylations of Unsaturated C−C Bonds"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892096788096","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Fluoroalkylation methods for synthesizing versatile building blocks"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/anie.201405401"},{"@type":"CROSSREF","@value":"10.1246/bcsj.20190080_references_DOI_X89TalPwtZM1UB9DKPNjX3mSu55"},{"@type":"CROSSREF","@value":"10.1021/jacs.1c09705_references_DOI_X89TalPwtZM1UB9DKPNjX3mSu55"},{"@type":"CROSSREF","@value":"10.1002/adsc.202201268_references_DOI_X89TalPwtZM1UB9DKPNjX3mSu55"}]}