{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544420915499264.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.jff.2021.104443"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S175646462100092X?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S175646462100092X?httpAccept=text/plain"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@value":"A novel amorphous preparation improved curcumin bioavailability in healthy volunteers: A single-dose, double-blind, two-way crossover study"}],"description":[{"notation":[{"@value":"Curcumin derived from Curcuma longa has beneficial pharmacological effects. However, its bioavailability is very low. To improve its bioavailability, we developed a novel amorphous formulation of curcumin, called curcuRougeTM. We investigated the bioavailability of curcuRougeTM and compared its efficiency with that of Theracurmin®. Male Sprague–Dawley rats were orally administered curcuRougeTM or Theracurmin® (10 mg/kg of curcumin). Based on the area under the plasma concentration-time curve, the bioavailability of curcuRougeTM was 3.7-fold higher than that of Theracurmin® in rats. We performed a single-dose, double-blind, two-way crossover study to compare the bioavailability of curcuRougeTM and Theracurmin® (90 mg of curcumin) in 12 volunteers (8 males, 4 females). The bioavailability of curcuRougeTM was 3.4-fold higher than that of Theracurmin®. curcuRougeTM achieved Cmax in a shorter time than Theracurmin® in both experiments. These findings indicate that curcuRougeTM, an amorphous formulation of curcumin, shows superior bioavailability to that of Theracurmin®."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544420915499273","@type":"Researcher","foaf:name":[{"@value":"Yoichi Sunagawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499271","@type":"Researcher","foaf:name":[{"@value":"Yusuke Miyazaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499267","@type":"Researcher","foaf:name":[{"@value":"Masafumi Funamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499264","@type":"Researcher","foaf:name":[{"@value":"Kana Shimizu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499268","@type":"Researcher","foaf:name":[{"@value":"Satoshi Shimizu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499269","@type":"Researcher","foaf:name":[{"@value":"Sari Nurmila"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499272","@type":"Researcher","foaf:name":[{"@value":"Yasufumi Katanasaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499136","@type":"Researcher","foaf:name":[{"@value":"Masashi Ito"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499265","@type":"Researcher","foaf:name":[{"@value":"Tatsuya Ogawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499274","@type":"Researcher","foaf:name":[{"@value":"Hitomi Ozawa-Umeta"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326232517760","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"50283594"},{"@type":"NRID","@value":"1000050283594"},{"@type":"NRID","@value":"9000018753546"},{"@type":"NRID","@value":"9000003868027"},{"@type":"NRID","@value":"9000002702887"},{"@type":"NRID","@value":"9000314379077"},{"@type":"NRID","@value":"9000015182035"},{"@type":"NRID","@value":"9000398273588"},{"@type":"NRID","@value":"9000283344737"},{"@type":"NRID","@value":"9000008285296"},{"@type":"NRID","@value":"9000386284649"}],"foaf:name":[{"@value":"Koji Hasegawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544420915499266","@type":"Researcher","foaf:name":[{"@value":"Tatsuya Morimoto"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"17564646"}],"prism:publicationName":[{"@value":"Journal of Functional Foods"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2021-06","prism:volume":"81","prism:startingPage":"104443"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S175646462100092X?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S175646462100092X?httpAccept=text/plain"}],"createdAt":"2021-04-07","modifiedAt":"2025-10-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Theracurmin%C2%AE","dc:title":"Theracurmin®"},{"@id":"https://cir.nii.ac.jp/all?q=Curcumin","dc:title":"Curcumin"},{"@id":"https://cir.nii.ac.jp/all?q=Bioavailability","dc:title":"Bioavailability"},{"@id":"https://cir.nii.ac.jp/all?q=Nutrition.%20Foods%20and%20food%20supply","dc:title":"Nutrition. 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