{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362544421318428160.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.jamcollsurg.2008.10.031"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1072751508015457?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S1072751508015457?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://journals.lww.com/00019464-200903000-00007"}},{"identifier":{"@type":"PMID","@value":"19317998"}}],"dc:title":[{"@value":"Surgical Contribution to Recurrence-Free Survival in Patients with Macrovascular–Invasion−Negative Hepatocellular Carcinoma"}],"description":[{"notation":[{"@value":"Macroscopic vascular invasion (MVI) is a well-known indicator of recurrence of hepatocellular carcinoma (HCC) even after curative hepatectomy, but the clinicopathologic and molecular features of the recurrence remain unclear in MVI-negative HCC.Two hundred seven consecutive patients with confirmed primary MVI-negative HCC were retrospectively assessed after curative resection, with special emphasis on the importance of anatomically systematized hepatectomy. HCC tissues were also analyzed for genome-wide gene expression profile of each tumor using a microarray technique.Univariant analysis of HCC recurrence revealed multiple tumors (p0.001), moderate to poor differentiation (p = 0.044), Child-Pugh B/C (p = 0.047), alpha-fetoprotein elevation (p = 0.007), and nonanatomic hepatectomy (p = 0.010) as risk factors. According to Cox hazard multivariant analysis, multiple tumors (p = 0.002), alpha-fetoprotein elevation (p0.001), and nonanatomic hepatectomy (p = 0.002) were identified as independent factors of the recurrence. In the recurrent cases after anatomic hepatectomy for HCC, local recurrence was significantly infrequent compared with those after nonanatomic hepatectomy (p0.001). Network expression analysis using cDNA microarray revealed distinct signaling pathways of epithelial-mesenchymal transitions are associated with recurrence after anatomically systematized hepatectomy.Anatomically systematized hepatectomy might contribute to recurrence-free survival of HCC patients of HCC without MVI. Local recurrence could be mostly averted by anatomic hepatectomy, although specific epithelial-mesenchymal transitions signaling might regulate the biologic aggressiveness of HCC."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382544421318428161","@type":"Researcher","foaf:name":[{"@value":"Shinji Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544421318428160","@type":"Researcher","foaf:name":[{"@value":"Kaoru Mogushi"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544421318428290","@type":"Researcher","foaf:name":[{"@value":"Mahmut Yasen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544421318428291","@type":"Researcher","foaf:name":[{"@value":"Norio Noguchi"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544421318428292","@type":"Researcher","foaf:name":[{"@value":"Atsushi Kudo"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544421318428288","@type":"Researcher","foaf:name":[{"@value":"Toshiaki Kurokawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544421318428164","@type":"Researcher","foaf:name":[{"@value":"Noriaki Nakamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544421318428162","@type":"Researcher","foaf:name":[{"@value":"Johji Inazawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544421318428289","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Tanaka"}]},{"@id":"https://cir.nii.ac.jp/crid/1382544421318428163","@type":"Researcher","foaf:name":[{"@value":"Shigeki Arii"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10727515"}],"prism:publicationName":[{"@value":"Journal of the American College of Surgeons"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2009-03","prism:volume":"208","prism:number":"3","prism:startingPage":"368","prism:endingPage":"374e128"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S1072751508015457?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S1072751508015457?httpAccept=text/plain"},{"@id":"https://journals.lww.com/00019464-200903000-00007"}],"createdAt":"2009-02-22","modifiedAt":"2022-04-22","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinoma,%20Hepatocellular","dc:title":"Carcinoma, Hepatocellular"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Expression%20Profiling","dc:title":"Gene Expression Profiling"},{"@id":"https://cir.nii.ac.jp/all?q=Liver%20Neoplasms","dc:title":"Liver Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Disease-Free%20Survival","dc:title":"Disease-Free Survival"},{"@id":"https://cir.nii.ac.jp/all?q=ErbB%20Receptors","dc:title":"ErbB Receptors"},{"@id":"https://cir.nii.ac.jp/all?q=Hepatectomy","dc:title":"Hepatectomy"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Invasiveness","dc:title":"Neoplasm Invasiveness"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Recurrence,%20Local","dc:title":"Neoplasm Recurrence, Local"},{"@id":"https://cir.nii.ac.jp/all?q=E2F1%20Transcription%20Factor","dc:title":"E2F1 Transcription Factor"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Staging","dc:title":"Neoplasm Staging"},{"@id":"https://cir.nii.ac.jp/all?q=Retrospective%20Studies","dc:title":"Retrospective 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