{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825893256232192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1023/b:card.0000041249.35724.da"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/content/pdf/10.1023/B:CARD.0000041249.35724.da.pdf"}},{"identifier":{"@type":"URI","@value":"https://link.springer.com/article/10.1023/B:CARD.0000041249.35724.da/fulltext.html"}},{"identifier":{"@type":"PMID","@value":"15367827"}}],"dc:title":[{"@value":"Differentiation of the Electrophysiological Effects on the Atrial Myocardium Between the Pure Na Channel Blocker, Pilsicainide, and Flecainide"}],"description":[{"notation":[{"@value":"The purpose of this study was to identify the difference between the pure Na channel blocker, pilsicainide and Ic-antiarrhythmic drug, flecainide, on the atrial electrophysiological characteristics.The subjects consisted of 24 patients (48 +/- 12 years-old: P-group) in whom pilsicainide was administrated intravenously (1 mg/kg/10 min) and 31 patients (47 +/- 15 years-old: F-group) in whom flecainide was administrated intravenously (2 mg/kg/10 min). The atrial effective refractory period (ERP-A), intra-atrial conduction time (CT), max intra-atrial conduction delay (Max CD), repetitive atrial firing zone (RAFZ), fragmented atrial activity zone (FAZ) and intra-atrial conduction delay zone (CDZ) were measured before and after the drugs.Pilsicainide and flecainide significantly prolonged the ERP-A (211 +/- 27 msec to 246 +/- 39 msec; p0.001, 217 +/- 25 msec to 244 +/- 33 msec; p0.001, respectively) and CT (121 +/- 33 msec to 149 +/- 43 msec; p0.001, 122 +/- 22 msec to 153 +/- 27 msec; p0.001, respectively) to the same degree. However, the Max CD was shortened by pilsicainide, but not by flecainide. The RAFZ, FAZ and CDZ decreased in the P-group (21 +/- 25 msec to 4 +/- 10 msec; p0.01, 24 +/- 24 msec to 14 +/- 18 msec; p0.05, 56 +/- 29 msec to 43 +/- 32 msec, p0.05, respectively), but not in the F-group.The effects of atrial conduction delays may differ between pilsicainide and flecainide. Further examination will be needed to explain this mechanism."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825893256232064","@type":"Researcher","foaf:name":[{"@value":"Masashi Kanemoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893256232201","@type":"Researcher","foaf:name":[{"@value":"Akihiko Shimizu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893256232193","@type":"Researcher","foaf:name":[{"@value":"Toshihiko Yamagata"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893256232194","@type":"Researcher","foaf:name":[{"@value":"Masahiro Esato"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893256232200","@type":"Researcher","foaf:name":[{"@value":"Takeshi Ueyama"}]},{"@id":"https://cir.nii.ac.jp/crid/1420282801192832128","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00423393"},{"@type":"NRID","@value":"1000000423393"},{"@type":"NRID","@value":"9000004089961"},{"@type":"NRID","@value":"9000021676500"},{"@type":"NRID","@value":"9000283098782"},{"@type":"NRID","@value":"9000258284131"},{"@type":"NRID","@value":"9000256310104"},{"@type":"NRID","@value":"9000004132495"},{"@type":"NRID","@value":"9000021668585"},{"@type":"NRID","@value":"9000021681844"},{"@type":"NRID","@value":"9000397833320"},{"@type":"NRID","@value":"9000391375269"},{"@type":"NRID","@value":"9000022001371"},{"@type":"NRID","@value":"9000345253298"},{"@type":"NRID","@value":"9000300215084"},{"@type":"NRID","@value":"9000256310610"},{"@type":"NRID","@value":"9000256311162"},{"@type":"NRID","@value":"9000256310783"},{"@type":"NRID","@value":"9000309178946"},{"@type":"NRID","@value":"9000415090495"},{"@type":"NRID","@value":"9000283128888"},{"@type":"NRID","@value":"9000300215193"},{"@type":"NRID","@value":"9000283129865"},{"@type":"NRID","@value":"9000021965231"},{"@type":"NRID","@value":"9000283129744"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/7000022157"}],"foaf:name":[{"@value":"Yasuhiro Yoshiga"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893256232196","@type":"Researcher","foaf:name":[{"@value":"Hiroyuki Kakugawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893256232199","@type":"Researcher","foaf:name":[{"@value":"Ryousuke Kametani"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893256232197","@type":"Researcher","foaf:name":[{"@value":"Noriko Inoue"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893256232192","@type":"Researcher","foaf:name":[{"@value":"Akira Sawa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893256232195","@type":"Researcher","foaf:name":[{"@value":"Masunori Matsuzaki"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09203206"},{"@type":"EISSN","@value":"15737241"}],"prism:publicationName":[{"@value":"Cardiovascular Drugs and Therapy"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2004-07","prism:volume":"18","prism:number":"4","prism:startingPage":"295","prism:endingPage":"303"},"reviewed":"false","dc:rights":["https://www.springernature.com/gp/researchers/text-and-data-mining","https://www.springernature.com/gp/researchers/text-and-data-mining"],"url":[{"@id":"https://link.springer.com/content/pdf/10.1023/B:CARD.0000041249.35724.da.pdf"},{"@id":"https://link.springer.com/article/10.1023/B:CARD.0000041249.35724.da/fulltext.html"}],"createdAt":"2004-09-14","modifiedAt":"2025-06-27","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Refractory%20Period,%20Electrophysiological","dc:title":"Refractory Period, Electrophysiological"},{"@id":"https://cir.nii.ac.jp/all?q=Heart%20Ventricles","dc:title":"Heart Ventricles"},{"@id":"https://cir.nii.ac.jp/all?q=Electrocardiography","dc:title":"Electrocardiography"},{"@id":"https://cir.nii.ac.jp/all?q=Heart%20Conduction%20System","dc:title":"Heart Conduction System"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Tachycardia,%20Atrioventricular%20Nodal%20Reentry","dc:title":"Tachycardia, Atrioventricular Nodal Reentry"},{"@id":"https://cir.nii.ac.jp/all?q=Heart%20Atria","dc:title":"Heart Atria"},{"@id":"https://cir.nii.ac.jp/all?q=Prospective%20Studies","dc:title":"Prospective Studies"},{"@id":"https://cir.nii.ac.jp/all?q=Flecainide","dc:title":"Flecainide"},{"@id":"https://cir.nii.ac.jp/all?q=Myocardium","dc:title":"Myocardium"},{"@id":"https://cir.nii.ac.jp/all?q=Lidocaine","dc:title":"Lidocaine"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Treatment%20Outcome","dc:title":"Treatment Outcome"},{"@id":"https://cir.nii.ac.jp/all?q=Atrial%20Flutter","dc:title":"Atrial Flutter"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Design","dc:title":"Research Design"},{"@id":"https://cir.nii.ac.jp/all?q=Tachycardia,%20Ventricular","dc:title":"Tachycardia, Ventricular"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Wolff-Parkinson-White%20Syndrome","dc:title":"Wolff-Parkinson-White Syndrome"},{"@id":"https://cir.nii.ac.jp/all?q=Electrophysiologic%20Techniques,%20Cardiac","dc:title":"Electrophysiologic Techniques, Cardiac"},{"@id":"https://cir.nii.ac.jp/all?q=Anti-Arrhythmia%20Agents","dc:title":"Anti-Arrhythmia Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Sodium%20Channel%20Blockers","dc:title":"Sodium Channel Blockers"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848661719400832","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Right ventricular dysfunction in patients with Brugada-like electrocardiography: a two dimensional strain imaging study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680155261312","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Simultaneous Assessment of Pharmacokinetics of Pilsicainide Transdermal Patch and Its Electropharmacological Effects on Atria of Chronic Atrioventricular Block Dogs"},{"@value":"Simultaneous assessment of pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects on atria of chronic AVB dogs"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1023/b:card.0000041249.35724.da"},{"@type":"OPENAIRE","@value":"doi_dedup___::95c1d90321381c7caf0180d39e64e53c"},{"@type":"CROSSREF","@value":"10.1254/jphs.09061sc_references_DOI_6Aw89MGuz7DSsdT75IMViMq8BmH"},{"@type":"CROSSREF","@value":"10.1186/1476-7120-9-30_references_DOI_6Aw89MGuz7DSsdT75IMViMq8BmH"}]}