{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825893259192704.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1074/jbc.m600861200"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820557657?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820557657?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1074/jbc.M600861200"}},{"identifier":{"@type":"PMID","@value":"16618699"}}],"dc:title":[{"@value":"Cyanidin-3-glucoside, a Natural Product Derived from Blackberry, Exhibits Chemopreventive and Chemotherapeutic Activity"}],"description":[{"notation":[{"@value":"Epidemiological data suggest that consumption of fruits and vegetables has been associated with a lower incidence of cancer. Cyanidin-3-glucoside (C3G), a compound found in blackberry and other food products, was shown to possess chemopreventive and chemotherapeutic activity in the present study. In cultured JB6 cells, C3G was able to scavenge ultraviolet B-induced *OH and O2-* radicals. In vivo studies indicated that C3G treatment decreased the number of non-malignant and malignant skin tumors per mouse induced by 12-O-tetradecanolyphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene-initiated mouse skin. Pretreatment of JB6 cells with C3G inhibited UVB- and TPA-induced transactivation of NF-kappaB and AP-1 and expression of cyclooxygenase-2 and tumor necrosis factor-alpha. These inhibitory effects appear to be mediated through the inhibition of MAPK activity. C3G also blocked TPA-induced neoplastic transformation in JB6 cells. In addition, C3G inhibited proliferation of a human lung carcinoma cell line, A549. Animal studies showed that C3G reduced the size of A549 tumor xenograft growth and significantly inhibited metastasis in nude mice. Mechanistic studies indicated that C3G inhibited migration and invasion of A549 tumor cells. These finding demonstrate for the first time that a purified compound of anthocyanin inhibits tumor promoter-induced carcinogenesis and tumor metastasis in vivo."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825893259192705","@type":"Researcher","foaf:name":[{"@value":"Min Ding"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893259192708","@type":"Researcher","foaf:name":[{"@value":"Rentian Feng"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893259192706","@type":"Researcher","foaf:name":[{"@value":"Shiow Y. Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893259192576","@type":"Researcher","foaf:name":[{"@value":"Linda Bowman"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893259192711","@type":"Researcher","foaf:name":[{"@value":"Yongju Lu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893259192709","@type":"Researcher","foaf:name":[{"@value":"Yong Qian"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893259192707","@type":"Researcher","foaf:name":[{"@value":"Vincent Castranova"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893259192710","@type":"Researcher","foaf:name":[{"@value":"Bing-Hua Jiang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893259192704","@type":"Researcher","foaf:name":[{"@value":"Xianglin Shi"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219258"}],"prism:publicationName":[{"@value":"Journal of Biological Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2006-06","prism:volume":"281","prism:number":"25","prism:startingPage":"17359","prism:endingPage":"17368"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0021925820557657?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0021925820557657?httpAccept=text/plain"},{"@id":"https://syndication.highwire.org/content/doi/10.1074/jbc.M600861200"}],"createdAt":"2006-04-18","modifiedAt":"2022-01-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Transcriptional%20Activation","dc:title":"Transcriptional Activation"},{"@id":"https://cir.nii.ac.jp/all?q=Wound%20Healing","dc:title":"Wound Healing"},{"@id":"https://cir.nii.ac.jp/all?q=Skin%20Neoplasms","dc:title":"Skin Neoplasms"},{"@id":"https://cir.nii.ac.jp/all?q=Plant%20Extracts","dc:title":"Plant Extracts"},{"@id":"https://cir.nii.ac.jp/all?q=Ultraviolet%20Rays","dc:title":"Ultraviolet Rays"},{"@id":"https://cir.nii.ac.jp/all?q=Antineoplastic%20Agents","dc:title":"Antineoplastic Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Anthocyanins","dc:title":"Anthocyanins"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Glucosides","dc:title":"Glucosides"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20DBA","dc:title":"Mice, Inbred DBA"},{"@id":"https://cir.nii.ac.jp/all?q=Cell%20Line,%20Tumor","dc:title":"Cell Line, Tumor"},{"@id":"https://cir.nii.ac.jp/all?q=Fruit","dc:title":"Fruit"},{"@id":"https://cir.nii.ac.jp/all?q=Benz(a)Anthracenes","dc:title":"Benz(a)Anthracenes"},{"@id":"https://cir.nii.ac.jp/all?q=Carcinogens","dc:title":"Carcinogens"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Anticarcinogenic%20Agents","dc:title":"Anticarcinogenic Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Tetradecanoylphorbol%20Acetate","dc:title":"Tetradecanoylphorbol Acetate"},{"@id":"https://cir.nii.ac.jp/all?q=Neoplasm%20Metastasis","dc:title":"Neoplasm Metastasis"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1363383444044798592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Hexane Insoluble Fraction from Purple Rice Extract Retards Carcinogenesis and Castration-Resistant Cancer Growth of Prostate Through Suppression of Androgen Receptor Mediated Cell Proliferation and Metabolism"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204457787904","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Differential Effects of Cyanidin and Cyanidin-3-glucoside on Human Cell Lines"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282763017897600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Maca Cosmetics: A Review on Constituents, Therapeutics and Advantages"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942153711616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. 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