{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825893287312640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/s41467-019-10386-8"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-019-10386-8.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/s41467-019-10386-8"}}],"dc:title":[{"@value":"Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>The pathological mechanisms of radiation ulcer remain unsolved and there is currently no effective medicine. Here, we demonstrate that persistent DNA damage foci and cell senescence are involved in radiation ulcer development. Further more, we identify cordycepin, a natural nucleoside analogue, as a potent drug to block radiation ulcer (skin, intestine, tongue) in rats/mice by preventing cell senescence through the increase of NRF2 nuclear expression (the assay used is mainly on skin). Finally, cordycepin is also revealed to activate AMPK by binding with the α1 and γ1 subunit near the autoinhibitory domain of AMPK, then promotes p62-dependent autophagic degradation of Keap1, to induce NRF2 dissociate from Keap1 and translocate to the nucleus. Taken together, our findings identify cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents, and activation of AMPK or NRF2 may thus represent therapeutic targets for preventing cell senescence and radiation ulcer.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825893287312651","@type":"Researcher","foaf:name":[{"@value":"Ziwen Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312650","@type":"Researcher","foaf:name":[{"@value":"Zelin Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312770","@type":"Researcher","foaf:name":[{"@value":"Zhongyong Jiang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312640","@type":"Researcher","foaf:name":[{"@value":"Peng Luo"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312645","@type":"Researcher","foaf:name":[{"@value":"Lang Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312772","@type":"Researcher","foaf:name":[{"@value":"Yu Huang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312768","@type":"Researcher","foaf:name":[{"@value":"Huilan Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312658","@type":"Researcher","foaf:name":[{"@value":"Yu Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312659","@type":"Researcher","foaf:name":[{"@value":"Lei Long"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312649","@type":"Researcher","foaf:name":[{"@value":"Xu Tan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312648","@type":"Researcher","foaf:name":[{"@value":"Dengqun Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312655","@type":"Researcher","foaf:name":[{"@value":"Taotao Jin"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312643","@type":"Researcher","foaf:name":[{"@value":"Yawei Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312771","@type":"Researcher","foaf:name":[{"@value":"Yang Wang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312656","@type":"Researcher","foaf:name":[{"@value":"Fengying Liao"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312647","@type":"Researcher","foaf:name":[{"@value":"Chi Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312652","@type":"Researcher","foaf:name":[{"@value":"Long Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312769","@type":"Researcher","foaf:name":[{"@value":"Yibo Gan"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312660","@type":"Researcher","foaf:name":[{"@value":"Yunsheng Liu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312642","@type":"Researcher","foaf:name":[{"@value":"Fan Yang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312641","@type":"Researcher","foaf:name":[{"@value":"Chunji Huang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312653","@type":"Researcher","foaf:name":[{"@value":"Hongming Miao"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312654","@type":"Researcher","foaf:name":[{"@value":"Jieping Chen"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312646","@type":"Researcher","foaf:name":[{"@value":"Tianmin Cheng"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312644","@type":"Researcher","foaf:name":[{"@value":"Xiaobing Fu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893287312657","@type":"Researcher","foaf:name":[{"@value":"Chunmeng Shi"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20411723"}],"prism:publicationName":[{"@value":"Nature Communications"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2019-06-10","prism:volume":"10","prism:number":"1","prism:startingPage":"2538"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/s41467-019-10386-8.pdf"},{"@id":"https://www.nature.com/articles/s41467-019-10386-8"}],"createdAt":"2019-06-10","modifiedAt":"2022-12-16","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360009142695069824","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298757164649344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/s41467-019-10386-8"},{"@type":"CROSSREF","@value":"10.1128/mcb.00099-20_references_DOI_LblrZOdmYOhgqUZALyO1JzuSQSN"},{"@type":"CROSSREF","@value":"10.1016/j.freeradbiomed.2022.06.239_references_DOI_LblrZOdmYOhgqUZALyO1JzuSQSN"}]}