Fluorous Synthesis: A Fluorous-Phase Strategy for Improving Separation Efficiency in Organic Synthesis
-
- Armido Studer
- Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
-
- Sabine Hadida
- Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
-
- Rafael Ferritto
- Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
-
- Sun-Young Kim
- Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
-
- Patrick Jeger
- Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
-
- Peter Wipf
- Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
-
- Dennis P. Curran
- Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Search this article
Description
<jats:p>Recovery and purification difficulties can limit the yield and utility of otherwise successful organic synthesis strategies. A “fluorous synthesis” approach is outlined in which organic molecules are rendered soluble in fluorocarbon solvents by attachment of a suitable fluorocarbon group. Fluorocarbon solvents are usually immiscible in organic solutions, and fluorous molecules partition out of an organic phase and into a fluorous phase in a standard liquid-liquid extraction. Simple yet substantive separations of organic reaction mixtures are achieved without resorting to chromatography. Because fluorous synthesis combines in many respects the favorable purification features of solid-phase synthesis with the favorable reaction, identification, and analysis features of traditional organic synthesis, it should prove valuable in the automated synthesis of libraries of individual pure organic compounds.</jats:p>
Journal
-
- Science
-
Science 275 (5301), 823-826, 1997-02-07
American Association for the Advancement of Science (AAAS)
- Tweet
Details 詳細情報について
-
- CRID
- 1362825893338140800
-
- NII Article ID
- 80009497090
-
- ISSN
- 10959203
- 00368075
-
- Data Source
-
- Crossref
- CiNii Articles
