{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825893343671424.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/j.amjcard.2011.01.045"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0002914911003894?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0002914911003894?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"21420053"}}],"dc:title":[{"@value":"A New Protocol Using Sodium Bicarbonate for the Prevention of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography"}],"description":[{"notation":[{"@value":"Contrast-induced nephropathy (CIN) is associated with increased morbidity and mortality rates. Although a previous study reported that pretreatment with sodium bicarbonate is more effective than sodium chloride for prophylaxis of CIN, this has not been a universal finding. We performed a prospective randomized trial to investigate whether CIN can be avoided using sodium bicarbonate. In total 155 patients with a glomerular filtration rate (GFR)60 ml/min/1.73 m(2) who were undergoing coronary angiography were enrolled. We assigned patients to sodium chloride plus sodium bicarbonate (bicarbonate group, n = 78) or sodium chloride alone (chloride group, n = 77). Infusion of sodium bicarbonate at 1 ml/kg/hour continued from 3 hours before to 6 hours after coronary angiography. CIN was defined as a 25% increase in serum creatinine from baseline value or an absolute increase of ≥0.5 mg/dl, which appeared within 2 days of contrast. Baseline GFR was not significantly different between the 2 groups. Patients in the bicarbonate group had a higher GFR than those in the chloride group on day 2 (45.8 ± 13.4 vs 40.9 ± 14.6 ml/min/1.73 m(2), p = 0.031) and at 1 month (49.5 ± 14.7 vs 43.7 ± 15.5 ml/min/1.73 m(2), p = 0.019). CIN occurred in 10 patients (13%) in the chloride group but in only 2 patients (2.6%) in the bicarbonate group (p = 0.012). Sodium chloride plus sodium bicarbonate is more effective than sodium chloride alone for prophylaxis of CIN and can lead to retention of better long-term renal function."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825893343671425","@type":"Researcher","foaf:name":[{"@value":"Masayuki Motohiro"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893343671424","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Kamihata"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893343671427","@type":"Researcher","foaf:name":[{"@value":"Satoshi Tsujimoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893343671553","@type":"Researcher","foaf:name":[{"@value":"Takeshi Seno"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893343671429","@type":"Researcher","foaf:name":[{"@value":"Kenichi Manabe"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893343671426","@type":"Researcher","foaf:name":[{"@value":"Tsuyoshi Isono"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893343671552","@type":"Researcher","foaf:name":[{"@value":"Yasuo Sutani"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893343671428","@type":"Researcher","foaf:name":[{"@value":"Fumio Yuasa"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893343671430","@type":"Researcher","foaf:name":[{"@value":"Toshiji Iwasaka"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00029149"}],"prism:publicationName":[{"@value":"The American Journal of Cardiology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2011-06","prism:volume":"107","prism:number":"11","prism:startingPage":"1604","prism:endingPage":"1608"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0002914911003894?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0002914911003894?httpAccept=text/plain"}],"createdAt":"2011-05-12","modifiedAt":"2021-11-23","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Contrast%20Media","dc:title":"Contrast Media"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Sodium%20Chloride","dc:title":"Sodium Chloride"},{"@id":"https://cir.nii.ac.jp/all?q=Coronary%20Angiography","dc:title":"Coronary Angiography"},{"@id":"https://cir.nii.ac.jp/all?q=Sodium%20Bicarbonate","dc:title":"Sodium Bicarbonate"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Kidney%20Diseases","dc:title":"Kidney Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390282752372831360","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Guideline on the Use of Iodinated Contrast Media in Patients With Kidney Disease 2018"},{"@value":"JCS GUIDELINES : Guideline on the Use of Iodinated Contrast Media in Patients With Kidney Disease 2018"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942143993216","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Guidelines on the use of iodinated contrast media in patients with kidney disease 2012 : digest version"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1016/j.amjcard.2011.01.045"},{"@type":"OPENAIRE","@value":"doi_dedup___::aca67f7cbb1e9a1455d57b786e07f473"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-19-0783_references_DOI_YiuNLh5ojh703BTOHqdoDJkKFdv"},{"@type":"CROSSREF","@value":"10.1007/s11604-019-00850-2_references_DOI_YiuNLh5ojh703BTOHqdoDJkKFdv"},{"@type":"CROSSREF","@value":"10.1007/s11604-013-0226-4_references_DOI_YiuNLh5ojh703BTOHqdoDJkKFdv"}]}