{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825893432397440.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.0901477106"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.0901477106"}}],"dc:title":[{"@value":"Genome-wide functional analysis reveals that infection-associated fungal autophagy is necessary for rice blast disease"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n                    To cause rice blast disease, the fungus\n                    <jats:italic>Magnaporthe oryzae</jats:italic>\n                    elaborates specialized infection structures called appressoria, which use enormous turgor to rupture the tough outer cuticle of a rice leaf. Here, we report the generation of a set of 22 isogenic\n                    <jats:italic>M. oryzae</jats:italic>\n                    mutants each differing by a single component of the predicted autophagic machinery of the fungus. Analysis of this set of targeted deletion mutants demonstrated that loss of any of the 16 genes necessary for nonselective macroautophagy renders the fungus unable to cause rice blast disease, due to impairment of both conidial programmed cell death and appressorium maturation. In contrast, genes necessary only for selective forms of autophagy, such as pexophagy and mitophagy, are dispensable for appressorium-mediated plant infection. A genome-wide analysis therefore demonstrates the importance of infection-associated, nonselective autophagy for the establishment of rice blast disease.\n                  </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825893432397440","@type":"Researcher","foaf:name":[{"@value":"Michael J. Kershaw"}],"jpcoar:affiliationName":[{"@value":"School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893432397312","@type":"Researcher","foaf:name":[{"@value":"Nicholas J. Talbot"}],"jpcoar:affiliationName":[{"@value":"School of Biosciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, United Kingdom"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2009-09-15","prism:volume":"106","prism:number":"37","prism:startingPage":"15967","prism:endingPage":"15972"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.0901477106"}],"createdAt":"2009-08-26","modifiedAt":"2022-05-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050282810697647744","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Yeast Methylotrophy and Autophagy in a Methanol-Oscillating Environment on Growing Arabidopsis thaliana Leaves"},{"@value":"Yeast methylotrophy and autophagy in a methanol-oscillating environment on growing <italic>Arabidopsis thaliana</italic> leaves."}]},{"@id":"https://cir.nii.ac.jp/crid/1050845763220927104","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Conserved fungal effector suppresses PAMP-triggered immunity by targeting plant immune kinases"}]},{"@id":"https://cir.nii.ac.jp/crid/1050856995323015168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Cell biology in phytopathogenic fungi during host infection: commonalities and differences"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004230839759616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Function of Peroxisomes in Plant-Pathogen Interactions"}]},{"@id":"https://cir.nii.ac.jp/crid/1360022307169390848","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Threonine synthase\n                  <i>CoTHR4</i>\n                  is involved in infection-related morphogenesis during the pre-penetration stage in\n                  <i>Colletotrichum orbiculare</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283691780169344","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Two distinct secretion systems facilitate tissue invasion by the rice blast fungus Magnaporthe oryzae"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283692333057792","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693446135808","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"<i>Colletotrichum orbiculare FAM1</i>\n            Encodes a Novel Woronin Body-Associated Pex22 Peroxin Required for Appressorium-Mediated Plant Infection"}]},{"@id":"https://cir.nii.ac.jp/crid/1360290617882504960","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360298336536838400","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Autophagy as a Survival Strategy for Eukaryotic Microbes Living in the 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