{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825893491011072.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1126/science.8036494"}},{"identifier":{"@type":"URI","@value":"https://www.science.org/doi/pdf/10.1126/science.8036494"}}],"dc:title":[{"@value":"The High-Resolution Crystal Structure of a Parallel-Stranded Guanine Tetraplex"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            Repeat tracts of guanine bases found in DNA and RNA can form tetraplex structures in the presence of a variety of monovalent cations. Evidence suggests that guanine tetraplexes assume important functions within chromosomal telomeres, immunoglobulin switch regions, and the human immunodeficiency virus genome. The structure of a parallel-stranded tetraplex formed by the hexanucleotide d(TG\n            <jats:sub>4</jats:sub>\n            T) and stabilized by sodium cations was determined by x-ray crystallography to 1.2 angstroms resolution. Sharply resolved sodium cations were found between and within planes of hydrogen-bonded guanine quartets, and an ordered groove hydration was observed. Distinct intra- and intermolecular stacking arrangements were adopted by the guanine quartets. Thymine bases were exclusively involved in making extensive lattice contacts.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825893491011074","@type":"Researcher","foaf:name":[{"@value":"Gerard Laughlan"}],"jpcoar:affiliationName":[{"@value":"Medical Research Council Virology Unit, University of Glasgow, Glasgow G11 5JR, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893491011072","@type":"Researcher","foaf:name":[{"@value":"Alastair I. H. Murchie"}],"jpcoar:affiliationName":[{"@value":"Cancer Research Campaign, Nucleic Acid Structure Research Group, Department of Biochemistry, The University, Dundee DD1 4HN, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893491011073","@type":"Researcher","foaf:name":[{"@value":"David G. Norman"}],"jpcoar:affiliationName":[{"@value":"Cancer Research Campaign, Nucleic Acid Structure Research Group, Department of Biochemistry, The University, Dundee DD1 4HN, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893491011077","@type":"Researcher","foaf:name":[{"@value":"Madeleine H. Moore"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, York University, Heslington, York YO1 5DD, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893491011076","@type":"Researcher","foaf:name":[{"@value":"Peter C. E. Moody"}],"jpcoar:affiliationName":[{"@value":"Department of Chemistry, York University, Heslington, York YO1 5DD, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893491011075","@type":"Researcher","foaf:name":[{"@value":"David M. J. Lilley"}],"jpcoar:affiliationName":[{"@value":"Cancer Research Campaign, Nucleic Acid Structure Research Group, Department of Biochemistry, The University, Dundee DD1 4HN, UK."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893491011200","@type":"Researcher","foaf:name":[{"@value":"Ben Luisi"}],"jpcoar:affiliationName":[{"@value":"Medical Research Council Virology Unit, University of Glasgow, Glasgow G11 5JR, UK."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00368075"},{"@type":"EISSN","@value":"10959203"}],"prism:publicationName":[{"@value":"Science"}],"dc:publisher":[{"@value":"American Association for the Advancement of Science (AAAS)"}],"prism:publicationDate":"1994-07-22","prism:volume":"265","prism:number":"5171","prism:startingPage":"520","prism:endingPage":"524"},"reviewed":"false","url":[{"@id":"https://www.science.org/doi/pdf/10.1126/science.8036494"}],"createdAt":"2006-10-06","modifiedAt":"2024-01-15","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050564288162641920","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy"},{"@value":"Sugiyama, Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004229996385664","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ligand Design to Acquire Specificity to Intended G‐Quadruplex 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