{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825893681899136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/ptr.5642"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fptr.5642"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.5642"}}],"dc:title":[{"@value":"Chemistry, Pharmacology and Health Benefits of Anthocyanins"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Anthocyanins are naturally occurring molecules belonging to the flavonoid class characterized by the presence of chromophores. Apart from their well‐known antioxidant activity, they show a wide variety of health‐promoting properties for human health, ranging from cytoprotective, antimicrobial and antitumour activities to neuroprotective, anti‐obesity and lipidomic potential, properties for which anthocyanins have been prescribed as medicines in several countries for thousands of years. Despite this, these phytochemicals have received less attention than other flavonoids, and there is still a gap in the literature, particularly regarding pharmacological and toxicological aspects. Moreover, epidemiological evidence suggests a direct correlation between anthocyanin intake and a lower incidence of chronic and degenerative diseases. In light of this, the aim of this review is to cover the current literature on anthocyanins, their biological <jats:italic>in vitro</jats:italic> and <jats:italic>in vivo</jats:italic> effects and their potential therapeutic applications, as well as their bioavailability and pharmacokinetics, all of which are essential to gain a better understanding of their biological effectiveness and potential toxicity. Copyright © 2016 John Wiley & Sons, Ltd.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825893681899139","@type":"Researcher","foaf:name":[{"@value":"Antonella Smeriglio"}],"jpcoar:affiliationName":[{"@value":"University of Messina Department of Chemical, Biological, Pharmaceutical and Environmental Sciences  Viale F. Stagno d'Alcontres 31 98166 Messina Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893681899136","@type":"Researcher","foaf:name":[{"@value":"Davide Barreca"}],"jpcoar:affiliationName":[{"@value":"University of Messina Department of Chemical, Biological, Pharmaceutical and Environmental Sciences  Viale F. Stagno d'Alcontres 31 98166 Messina Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893681899137","@type":"Researcher","foaf:name":[{"@value":"Ersilia Bellocco"}],"jpcoar:affiliationName":[{"@value":"University of Messina Department of Chemical, Biological, Pharmaceutical and Environmental Sciences  Viale F. Stagno d'Alcontres 31 98166 Messina Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893681899138","@type":"Researcher","foaf:name":[{"@value":"Domenico Trombetta"}],"jpcoar:affiliationName":[{"@value":"University of Messina Department of Chemical, Biological, Pharmaceutical and Environmental Sciences  Viale F. Stagno d'Alcontres 31 98166 Messina Italy"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0951418X"},{"@type":"EISSN","@value":"10991573"}],"prism:publicationName":[{"@value":"Phytotherapy Research"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2016-05-25","prism:volume":"30","prism:number":"8","prism:startingPage":"1265","prism:endingPage":"1286"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fptr.5642"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/ptr.5642"}],"createdAt":"2016-05-25","modifiedAt":"2023-10-05","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360286996354944896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antioxidant and Anti-Inflammatory Properties of Anthocyanins Extracted from <i>Oryza sativa</i> L. in Primary Dermal Fibroblasts"}]},{"@id":"https://cir.nii.ac.jp/crid/1390582484892016256","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Bioactivity of Flavonoids through Regulation of microRNA Expression"},{"@language":"ja","@value":"マイクロRNAの発現調節を介したフラボノイドの生体調節作用"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/ptr.5642"},{"@type":"CROSSREF","@value":"10.1155/2019/2089817_references_DOI_TzubbytmP4KMLEgfzAGcxrbDILO"},{"@type":"CROSSREF","@value":"10.1271/kagakutoseibutsu.61.371_references_DOI_TzubbytmP4KMLEgfzAGcxrbDILO"}]}