{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825893778256128.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/mds.26987"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmds.26987"}},{"identifier":{"@type":"URI","@value":"https://movementdisorders.onlinelibrary.wiley.com/doi/pdf/10.1002/mds.26987"}}],"dc:title":[{"@value":"Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>ABSTRACT</jats:title><jats:p><jats:bold>Background</jats:bold>: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome.</jats:p><jats:p><jats:bold>Objective</jats:bold>: We aimed to provide an evidence‐ and consensus‐based revision of the clinical diagnostic criteria for PSP.</jats:p><jats:p><jats:bold>Methods</jats:bold>: We searched the PubMed, Cochrane, Medline, and PSYCInfo databases for articles published in English since 1996, using postmortem diagnosis or highly specific clinical criteria as the diagnostic standard. Second, we generated retrospective standardized clinical data from patients with autopsy‐confirmed PSP and control diseases. On this basis, diagnostic criteria were drafted, optimized in two modified Delphi evaluations, submitted to structured discussions with consensus procedures during a 2‐day meeting, and refined in three further Delphi rounds.</jats:p><jats:p><jats:bold>Results</jats:bold>: Defined clinical, imaging, laboratory, and genetic findings serve as mandatory basic features, mandatory exclusion criteria, or context‐dependent exclusion criteria. We identified four functional domains (ocular motor dysfunction, postural instability, akinesia, and cognitive dysfunction) as clinical predictors of PSP. Within each of these domains, we propose three clinical features that contribute different levels of diagnostic certainty. Specific combinations of these features define the diagnostic criteria, stratified by three degrees of diagnostic certainty (probable PSP, possible PSP, and suggestive of PSP). Clinical clues and imaging findings represent supportive features.</jats:p><jats:p><jats:bold>Conclusions</jats:bold>: Here, we present new criteria aimed to optimize early, sensitive, and specific clinical diagnosis of PSP on the basis of currently available evidence. © 2017 International Parkinson and Movement Disorder Society</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825893778256144","@type":"Researcher","foaf:name":[{"@value":"Günter U. Höglinger"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Technische Universität München Munich Germany"},{"@value":"German Center for Neurodegenerative Diseases (DZNE) Munich Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256131","@type":"Researcher","foaf:name":[{"@value":"Gesine Respondek"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Technische Universität München Munich Germany"},{"@value":"German Center for Neurodegenerative Diseases (DZNE) Munich Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256001","@type":"Researcher","foaf:name":[{"@value":"Maria Stamelou"}],"jpcoar:affiliationName":[{"@value":"Second Department of Neurology Attikon University Hospital, University of Athens Athens Greece"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256257","@type":"Researcher","foaf:name":[{"@value":"Carolin Kurz"}],"jpcoar:affiliationName":[{"@value":"Department of Psychiatry Ludwig‐Maximilians‐Universität Munich Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256273","@type":"Researcher","foaf:name":[{"@value":"Keith A. Josephs"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Mayo Clinic Rochester Minnesota USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256267","@type":"Researcher","foaf:name":[{"@value":"Anthony E. Lang"}],"jpcoar:affiliationName":[{"@value":"Morton and Gloria Shulman Movement Disorders Clinic and the Edmond J. Safra Program in Parkinson's Disease Toronto Western Hospital Toronto Canada"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256150","@type":"Researcher","foaf:name":[{"@value":"Brit Mollenhauer"}],"jpcoar:affiliationName":[{"@value":"Paracelsus‐Elena Klinik, Kassel, Germany, and University Medical Center Göttingen, Institute of Neuropathology Göttingen Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256129","@type":"Researcher","foaf:name":[{"@value":"Ulrich Müller"}],"jpcoar:affiliationName":[{"@value":"Institute of Human Genetics Giessen Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256147","@type":"Researcher","foaf:name":[{"@value":"Christer Nilsson"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Sciences, Division of Neurology Lund University Lund Sweden"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256140","@type":"Researcher","foaf:name":[{"@value":"Jennifer L. Whitwell"}],"jpcoar:affiliationName":[{"@value":"Department of Radiology Mayo Clinic Rochester Minnesoya USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256135","@type":"Researcher","foaf:name":[{"@value":"Thomas Arzberger"}],"jpcoar:affiliationName":[{"@value":"German Center for Neurodegenerative Diseases (DZNE) Munich Germany"},{"@value":"Department of Psychiatry Ludwig‐Maximilians‐Universität Munich Germany"},{"@value":"Center for Neuropathology and Prion Research Ludwig‐Maximilians‐Universität Munich Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256260","@type":"Researcher","foaf:name":[{"@value":"Elisabet Englund"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Sciences Division of Oncology and Pathology, Lund University Lund Sweden"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256151","@type":"Researcher","foaf:name":[{"@value":"Ellen Gelpi"}],"jpcoar:affiliationName":[{"@value":"Neurological Tissue Bank of the Biobank ‐ Hospital Clínic de Barcelona Universitat de Barcelona, IDIBAPS Barcelona Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256132","@type":"Researcher","foaf:name":[{"@value":"Armin Giese"}],"jpcoar:affiliationName":[{"@value":"Center for Neuropathology and Prion Research Ludwig‐Maximilians‐Universität Munich Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256133","@type":"Researcher","foaf:name":[{"@value":"David J. Irwin"}],"jpcoar:affiliationName":[{"@value":"Frontotemporal Degeneration Center Department of Neurology, University of Pennsylvania Philadelphia Pennsylvania USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256141","@type":"Researcher","foaf:name":[{"@value":"Wassilios G. Meissner"}],"jpcoar:affiliationName":[{"@value":"Université de Bordeaux, Institut des Maladies Neurodégénératives UMR 5293 Bordeaux France"},{"@value":"CNRS, Institut des Maladies Neurodégénératives UMR 5293 Bordeaux France"},{"@value":"Service de Neurologie, Hôpital Pellegrin, CHU de Bordeaux Bordeaux France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256134","@type":"Researcher","foaf:name":[{"@value":"Alexander Pantelyat"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Johns Hopkins University Baltimore Maryland USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256149","@type":"Researcher","foaf:name":[{"@value":"Alex Rajput"}],"jpcoar:affiliationName":[{"@value":"Division of Neurology Royal University Hospital, University of Saskatchewan Saskatoon SK Canada"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256268","@type":"Researcher","foaf:name":[{"@value":"John C. van Swieten"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Erasmus Medical Centre Rotterdam The Netherlands"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256136","@type":"Researcher","foaf:name":[{"@value":"Claire Troakes"}],"jpcoar:affiliationName":[{"@value":"London Neurodegenerative Diseases Brain Bank Institute of Psychiatry, Psychology and Neuroscience, Kings College London London United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256137","@type":"Researcher","foaf:name":[{"@value":"Angelo Antonini"}],"jpcoar:affiliationName":[{"@value":"Parkinson and Movement Disorders Unit IRCCS Hospital San Camillo, Venice, and Department of Neurosciences, Padova University Padova Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256128","@type":"Researcher","foaf:name":[{"@value":"Kailash P. Bhatia"}],"jpcoar:affiliationName":[{"@value":"Sobell Department of Motor Neuroscience and Movement Disorders UCL Institute of Neurology Queen Square London United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256256","@type":"Researcher","foaf:name":[{"@value":"Yvette Bordelon"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology University of California Los Angeles California USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256259","@type":"Researcher","foaf:name":[{"@value":"Yaroslau Compta"}],"jpcoar:affiliationName":[{"@value":"Parkinson's Disease & Movement Disorders Unit Neurology Service, Hospital Clinic/IDIBAPS/University of Barcelona Barcelona, Catalonia Spain"}]},{"@id":"https://cir.nii.ac.jp/crid/1380306506178320640","@type":"Researcher","foaf:name":[{"@value":"Jean‐Christophe Corvol"}],"jpcoar:affiliationName":[{"@value":"Sorbonne Universités, UPMC Univ Paris 06; and INSERM UMRS_1127, CIC_1422; and CNRS UMR_7225; and AP‐HP; and ICM, Hôpital Pitié‐Salpêtrière, Département des maladies du système nerveux Paris France"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256153","@type":"Researcher","foaf:name":[{"@value":"Carlo Colosimo"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Santa Maria University Hospital of Terni Terni Italy"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256265","@type":"Researcher","foaf:name":[{"@value":"Dennis W. Dickson"}],"jpcoar:affiliationName":[{"@value":"Mayo Clinic Jacksonville Florida USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256145","@type":"Researcher","foaf:name":[{"@value":"Richard Dodel"}],"jpcoar:affiliationName":[{"@value":"Department of Geriatric Medicine University Hospital Essen  Essen Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256266","@type":"Researcher","foaf:name":[{"@value":"Leslie Ferguson"}],"jpcoar:affiliationName":[{"@value":"Division of Neurology Royal University Hospital, University of Saskatchewan Saskatoon SK Canada"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256148","@type":"Researcher","foaf:name":[{"@value":"Murray Grossman"}],"jpcoar:affiliationName":[{"@value":"Frontotemporal Degeneration Center Department of Neurology, University of Pennsylvania Philadelphia Pennsylvania USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256142","@type":"Researcher","foaf:name":[{"@value":"Jan Kassubek"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology University of Ulm Ulm Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256258","@type":"Researcher","foaf:name":[{"@value":"Florian Krismer"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Medical University Innsbruck Innsbruck Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256130","@type":"Researcher","foaf:name":[{"@value":"Johannes Levin"}],"jpcoar:affiliationName":[{"@value":"German Center for Neurodegenerative Diseases (DZNE) Munich Germany"},{"@value":"Department of Neurology Ludwig‐Maximilians‐Universität Munich Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256143","@type":"Researcher","foaf:name":[{"@value":"Stefan Lorenzl"}],"jpcoar:affiliationName":[{"@value":"Institute of Nursing Science and Practice Paracelsus Medical University Salzburg Austria"},{"@value":"Department of Neurology Hospital Agatharied Agatharied Germany"},{"@value":"Department of Palliative Medicine Munich University Hospital LMU Munich Munich Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256262","@type":"Researcher","foaf:name":[{"@value":"Huw R. Morris"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Neuroscience UCL Institute of Neurology London United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256146","@type":"Researcher","foaf:name":[{"@value":"Peter Nestor"}],"jpcoar:affiliationName":[{"@value":"German Center for Neurodegenerative Diseases (DZNE) Magdeburg Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256138","@type":"Researcher","foaf:name":[{"@value":"Wolfgang H. Oertel"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Philipps Universität Marburg Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256139","@type":"Researcher","foaf:name":[{"@value":"Werner Poewe"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Medical University Innsbruck Innsbruck Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256261","@type":"Researcher","foaf:name":[{"@value":"Gil Rabinovici"}],"jpcoar:affiliationName":[{"@value":"Memory and Aging Center Department of Neurology, University of California San Francisco California USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256269","@type":"Researcher","foaf:name":[{"@value":"James B. Rowe"}],"jpcoar:affiliationName":[{"@value":"Department of Clinical Neurosciences Cambridge University Cambridge United Kingdom"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256271","@type":"Researcher","foaf:name":[{"@value":"Gerard D. Schellenberg"}],"jpcoar:affiliationName":[{"@value":"Department of Pathology and Laboratory Medicine Perelman School of Medicine, University of Pennsylvania Philadelphia Pennsylvania USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256000","@type":"Researcher","foaf:name":[{"@value":"Klaus Seppi"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Medical University Innsbruck Innsbruck Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256264","@type":"Researcher","foaf:name":[{"@value":"Thilo van Eimeren"}],"jpcoar:affiliationName":[{"@value":"Departments of Nuclear Medicine and Neurology University of Cologne Cologne Germany"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256152","@type":"Researcher","foaf:name":[{"@value":"Gregor K. Wenning"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Medical University Innsbruck Innsbruck Austria"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256270","@type":"Researcher","foaf:name":[{"@value":"Adam L. Boxer"}],"jpcoar:affiliationName":[{"@value":"Memory and Aging Center Department of Neurology, University of California San Francisco California USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256002","@type":"Researcher","foaf:name":[{"@value":"Lawrence I. Golbe"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey USA"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893778256263","@type":"Researcher","foaf:name":[{"@value":"Irene Litvan"}],"jpcoar:affiliationName":[{"@value":"Department of Neurology University of California San Diego California USA"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"08853185"},{"@type":"EISSN","@value":"15318257"}],"prism:publicationName":[{"@value":"Movement Disorders"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2017-05-03","prism:volume":"32","prism:number":"6","prism:startingPage":"853","prism:endingPage":"864"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmds.26987"},{"@id":"https://movementdisorders.onlinelibrary.wiley.com/doi/pdf/10.1002/mds.26987"}],"createdAt":"2017-05-03","modifiedAt":"2025-10-20","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050025960417030784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Absolute quantitation of sympathetic nerve activity using [123I] metaiodobenzylguanidine SPECT-CT in neurology"}]},{"@id":"https://cir.nii.ac.jp/crid/1050287142187228160","@type":"Article","resourceType":"学術雑誌論文(journal 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