{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825893826071808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.1801745115"}},{"identifier":{"@type":"URI","@value":"http://www.pnas.org/syndication/doi/10.1073/pnas.1801745115"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.1801745115"}}],"dc:title":[{"@value":"Chemoproteomics reveals baicalin activates hepatic CPT1 to ameliorate diet-induced obesity and hepatic steatosis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Significance</jats:title>\n          <jats:p>\n            Baicalin is a major flavonoid component from the herbal medicine\n            <jats:italic>Scutellaria baicalensis</jats:italic>\n            that has been shown to have an antisteatosis effect. Through quantitative chemoproteomic profiling, we discovered that baicalin acts as a natural allosteric activator of carnitine palmitoyltransferase 1 (CPT1), the rate-limiting enzyme of fatty acid β-oxidation (FAO). By directly binding to CPT1 and activating its activity to accelerate fatty acid degradation, baicalin can significantly ameliorate symptoms associated with hepatic steatosis and reduce diet-induced obesity (DIO). Our study provides an example of a natural product agonist for CPT1. The results provide mechanistic insights to explain the bioactivity of baicalin in reducing lipid accumulation and introduce exciting opportunities for developing novel flavonoid-based FAO activators for pharmacologically treating DIO and associated metabolic disorders.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825893826071818","@type":"Researcher","foaf:name":[{"@value":"Jianye Dai"}],"jpcoar:affiliationName":[{"@value":"Synthetic and Functional Biomolecules Center, Peking University, 100871 Beijing, China;"},{"@value":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China;"},{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071812","@type":"Researcher","foaf:name":[{"@value":"Kai Liang"}],"jpcoar:affiliationName":[{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"},{"@value":"School of Life Sciences, Peking University, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071808","@type":"Researcher","foaf:name":[{"@value":"Shan Zhao"}],"jpcoar:affiliationName":[{"@value":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China;"},{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071815","@type":"Researcher","foaf:name":[{"@value":"Wentong Jia"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Stem Cells and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China;"},{"@value":"University of the Chinese Academy of Sciences, 101408 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071811","@type":"Researcher","foaf:name":[{"@value":"Yuan Liu"}],"jpcoar:affiliationName":[{"@value":"Synthetic and Functional Biomolecules Center, Peking University, 100871 Beijing, China;"},{"@value":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China;"},{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071814","@type":"Researcher","foaf:name":[{"@value":"Hongkun Wu"}],"jpcoar:affiliationName":[{"@value":"Institute of Molecular Medicine, Peking University, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071938","@type":"Researcher","foaf:name":[{"@value":"Jia Lv"}],"jpcoar:affiliationName":[{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"},{"@value":"Institute of Molecular Medicine, Peking University, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071809","@type":"Researcher","foaf:name":[{"@value":"Chen Cao"}],"jpcoar:affiliationName":[{"@value":"College of Engineering, Peking University, 100871 Beijing, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071942","@type":"Researcher","foaf:name":[{"@value":"Tao Chen"}],"jpcoar:affiliationName":[{"@value":"College of Engineering, Peking University, 100871 Beijing, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071940","@type":"Researcher","foaf:name":[{"@value":"Shentian Zhuang"}],"jpcoar:affiliationName":[{"@value":"Synthetic and Functional Biomolecules Center, Peking University, 100871 Beijing, China;"},{"@value":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China;"},{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071941","@type":"Researcher","foaf:name":[{"@value":"Xiaomeng Hou"}],"jpcoar:affiliationName":[{"@value":"Synthetic and Functional Biomolecules Center, Peking University, 100871 Beijing, China;"},{"@value":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China;"},{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071817","@type":"Researcher","foaf:name":[{"@value":"Shijie Zhou"}],"jpcoar:affiliationName":[{"@value":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China;"},{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071820","@type":"Researcher","foaf:name":[{"@value":"Xiannian Zhang"}],"jpcoar:affiliationName":[{"@value":"College of Engineering, Peking University, 100871 Beijing, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071813","@type":"Researcher","foaf:name":[{"@value":"Xiao-Wei Chen"}],"jpcoar:affiliationName":[{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"},{"@value":"Institute of Molecular Medicine, Peking University, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071819","@type":"Researcher","foaf:name":[{"@value":"Yanyi Huang"}],"jpcoar:affiliationName":[{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"},{"@value":"College of Engineering, Peking University, 100871 Beijing, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071816","@type":"Researcher","foaf:name":[{"@value":"Rui-Ping Xiao"}],"jpcoar:affiliationName":[{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"},{"@value":"Institute of Molecular Medicine, Peking University, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071939","@type":"Researcher","foaf:name":[{"@value":"Yan-Ling Wang"}],"jpcoar:affiliationName":[{"@value":"State Key Laboratory of Stem Cells and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100101 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071810","@type":"Researcher","foaf:name":[{"@value":"Tuoping Luo"}],"jpcoar:affiliationName":[{"@value":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China;"},{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071936","@type":"Researcher","foaf:name":[{"@value":"Junyu Xiao"}],"jpcoar:affiliationName":[{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"},{"@value":"School of Life Sciences, Peking University, 100871 Beijing, China;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825893826071937","@type":"Researcher","foaf:name":[{"@value":"Chu Wang"}],"jpcoar:affiliationName":[{"@value":"Synthetic and Functional Biomolecules Center, Peking University, 100871 Beijing, China;"},{"@value":"Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China;"},{"@value":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2018-06-11","prism:volume":"115","prism:number":"26"},"reviewed":"false","dc:rights":["http://www.pnas.org/site/aboutpnas/licenses.xhtml"],"url":[{"@id":"http://www.pnas.org/syndication/doi/10.1073/pnas.1801745115"},{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.1801745115"}],"createdAt":"2018-06-11","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1391975276373132160","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Acute Oral Toxicity and Acute Intraperitoneal Studies of Thermally Treated 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