{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894229554176.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1371/journal.pone.0175497"}},{"identifier":{"@type":"URI","@value":"http://dx.plos.org/10.1371/journal.pone.0175497"}},{"identifier":{"@type":"PMID","@value":"28394924"}}],"dc:title":[{"@value":"Microscale spatial analysis provides evidence for adhesive monopolization of dietary nutrients by specific intestinal bacteria"}],"description":[{"notation":[{"@value":"Each species of intestinal bacteria requires a nutritional source to maintain its population in the intestine. Dietary factors are considered to be major nutrients; however, evidence directly explaining the in situ utilization of dietary factors is limited. Microscale bacterial distribution would provide clues to understand bacterial lifestyle and nutrient utilization. However, the detailed bacterial localization around dietary factors in the intestine remains uninvestigated. Therefore, we explored microscale habitats in the murine intestine by using histology and fluorescent in situ hybridization, focusing on dietary factors. This approach successfully revealed several types of bacterial colonization. In particular, bifidobacterial colonization and adhesion on granular starch was frequently and commonly observed in the jejunum and distal colon. To identify the bacterial composition of areas around starch granules and areas without starch, laser microdissection and next-generation sequencing-based 16S rRNA microbial profiling was performed. It was found that Bifidobacteriaceae were significantly enriched by 4.7 fold in peri-starch areas compared to ex-starch areas. This family solely consisted of Bifidobacterium pseudolongum. In contrast, there was no significant enrichment among the other major families. This murine intestinal B. pseudolongum had starch-degrading activity, confirmed by isolation from the mouse feces and in vitro analysis. Collectively, our results demonstrate the significance of starch granules as a major habitat and potential nutritional niche for murine intestinal B. pseudolongum. Moreover, our results suggest that colonizing bifidobacteria effectively utilize starch from the closest location and maintain the location. This may be a bacterial strategy to monopolize solid dietary nutrients. We believe that our analytical approach could possibly be applied to other nutritional factors, and can be a powerful tool to investigate in vivo relationships between bacteria and environmental factors in the intestine."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825894229554178","@type":"Researcher","foaf:name":[{"@value":"Yusuke Nagara"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894229554180","@type":"Researcher","foaf:name":[{"@value":"Toshihiko Takada"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894229554177","@type":"Researcher","foaf:name":[{"@value":"Yuriko Nagata"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894229554176","@type":"Researcher","foaf:name":[{"@value":"Shoichi Kado"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894229554179","@type":"Researcher","foaf:name":[{"@value":"Akira Kushiro"}]}],"contributor":[{"@id":"https://cir.nii.ac.jp/crid/1382825894229554181","@type":"Researcher","foaf:name":[{"@value":"Yolanda Sanz"}],"role":"editor"}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"19326203"}],"prism:publicationName":[{"@value":"PLOS ONE"}],"dc:publisher":[{"@value":"Public Library of Science (PLoS)"}],"prism:publicationDate":"2017-04-10","prism:volume":"12","prism:number":"4","prism:startingPage":"e0175497"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"http://dx.plos.org/10.1371/journal.pone.0175497"}],"createdAt":"2017-04-10","modifiedAt":"2020-10-05","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Spatial%20Analysis","dc:title":"Spatial Analysis"},{"@id":"https://cir.nii.ac.jp/all?q=Science","dc:title":"Science"},{"@id":"https://cir.nii.ac.jp/all?q=Q","dc:title":"Q"},{"@id":"https://cir.nii.ac.jp/all?q=R","dc:title":"R"},{"@id":"https://cir.nii.ac.jp/all?q=Starch","dc:title":"Starch"},{"@id":"https://cir.nii.ac.jp/all?q=Bacterial%20Adhesion","dc:title":"Bacterial Adhesion"},{"@id":"https://cir.nii.ac.jp/all?q=Gastrointestinal%20Microbiome","dc:title":"Gastrointestinal Microbiome"},{"@id":"https://cir.nii.ac.jp/all?q=Intestines","dc:title":"Intestines"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Feces","dc:title":"Feces"},{"@id":"https://cir.nii.ac.jp/all?q=Food","dc:title":"Food"},{"@id":"https://cir.nii.ac.jp/all?q=RNA,%20Ribosomal,%2016S","dc:title":"RNA, Ribosomal, 16S"},{"@id":"https://cir.nii.ac.jp/all?q=Medicine","dc:title":"Medicine"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Bifidobacterium","dc:title":"Bifidobacterium"},{"@id":"https://cir.nii.ac.jp/all?q=Intestinal%20Mucosa","dc:title":"Intestinal Mucosa"},{"@id":"https://cir.nii.ac.jp/all?q=Microdissection","dc:title":"Microdissection"},{"@id":"https://cir.nii.ac.jp/all?q=In%20Situ%20Hybridization,%20Fluorescence","dc:title":"In Situ Hybridization, Fluorescence"},{"@id":"https://cir.nii.ac.jp/all?q=Research%20Article","dc:title":"Research Article"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360016861563074176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Histological study of diurnal changes in bacterial settlement in the rat alimentary 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