{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894295366144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1016/0165-5728(94)90049-3"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0165572894900493?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:0165572894900493?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"7509816"}}],"dc:title":[{"@value":"Suppressive effect of FK-506, a novel immunosuppressant, against MPTP-induced dopamine depletion in the striatum of young C57BL/6 mice"}],"description":[{"notation":[{"@value":"Systemic injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is known to damage the dopaminergic nigrostriatal system in C57BL/6 mice. We have investigated the effects of immunosuppressants, FK-506 and cyclosporin A (CsA), on MPTP-induced dopamine (DA) depletion in the striatum of young C57BL/6 mice. 10 days after MPTP treatment (25 mg/kg i.p. given daily, 5 days), DA in the striatum was depleted by 80%. However, pretreatment with FK-506, a novel immunosuppressant, significantly protected MPTP-induced DA depletion in the striatum, but FK-506 itself did not affect the DA content. CsA, another immunosuppressant, also protected MPTP-induced DA depletion. From these results can be seen that immunosuppressants seem to inhibit MPTP neurotoxicity toward nigrostriatal dopaminergic neurons of young C57BL/6 mice."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825894295366016","@type":"Researcher","foaf:name":[{"@value":"Yoshihisa Kitamura"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894295366144","@type":"Researcher","foaf:name":[{"@value":"Yasuhiro Itano"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894295366017","@type":"Researcher","foaf:name":[{"@value":"Tomiko Kubo"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894295366018","@type":"Researcher","foaf:name":[{"@value":"Yasuyuki Nomura"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01655728"}],"prism:publicationName":[{"@value":"Journal of Neuroimmunology"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"1994-03","prism:volume":"50","prism:number":"2","prism:startingPage":"221","prism:endingPage":"224"},"reviewed":"false","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","https://www.elsevier.com/legal/tdmrep-license"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:0165572894900493?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:0165572894900493?httpAccept=text/plain"}],"createdAt":"2002-12-28","modifiedAt":"2025-09-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Serotonin","dc:title":"Serotonin"},{"@id":"https://cir.nii.ac.jp/all?q=Dopamine","dc:title":"Dopamine"},{"@id":"https://cir.nii.ac.jp/all?q=Brain","dc:title":"Brain"},{"@id":"https://cir.nii.ac.jp/all?q=Corpus%20Striatum","dc:title":"Corpus Striatum"},{"@id":"https://cir.nii.ac.jp/all?q=Tacrolimus","dc:title":"Tacrolimus"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Inbred%20C57BL","dc:title":"Mice, Inbred C57BL"},{"@id":"https://cir.nii.ac.jp/all?q=Picibanil","dc:title":"Picibanil"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Norepinephrine","dc:title":"Norepinephrine"},{"@id":"https://cir.nii.ac.jp/all?q=1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","dc:title":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"},{"@id":"https://cir.nii.ac.jp/all?q=Cyclosporine","dc:title":"Cyclosporine"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Tissue%20Distribution","dc:title":"Tissue Distribution"},{"@id":"https://cir.nii.ac.jp/all?q=Immunosuppressive%20Agents","dc:title":"Immunosuppressive Agents"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285707275061376","@type":"Article","resourceType":"学術雑誌論文(journal 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