{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894332986752.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/php.12368"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fphp.12368"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/php.12368"}}],"dc:title":[{"@value":"Oxidatively Generated Damage to Cellular <scp>DNA</scp> by <scp>UVB</scp> and <scp>UVA</scp> Radiation<sup>,</sup>"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>This review article focuses on a critical survey of the main available information on the <jats:styled-content style=\"fixed-case\">UVB</jats:styled-content> and <jats:styled-content style=\"fixed-case\">UVA</jats:styled-content> oxidative reactions to cellular <jats:styled-content style=\"fixed-case\">DNA</jats:styled-content> as the result of direct interactions of <jats:styled-content style=\"fixed-case\">UV</jats:styled-content> photons, photosensitized pathways and biochemical responses including inflammation and bystander effects. <jats:styled-content style=\"fixed-case\">UVA</jats:styled-content> radiation appears to be much more efficient than <jats:styled-content style=\"fixed-case\">UVB</jats:styled-content> in inducing oxidatively generated damage to the bases and 2‐deoxyribose moieties of <jats:styled-content style=\"fixed-case\">DNA</jats:styled-content> in isolated cells and skin. The <jats:styled-content style=\"fixed-case\">UVA</jats:styled-content>‐induced generation of 8‐oxo‐7,8‐dihydroguanine is mostly rationalized in terms of selective guanine oxidation by singlet oxygen generated through type <jats:styled-content style=\"fixed-case\">II</jats:styled-content> photosensitization mechanism. In addition, hydroxyl radical whose formation may be accounted for by metal‐catalyzed Haber–Weiss reactions subsequent to the initial generation of superoxide anion radical contributes in a minor way to the <jats:styled-content style=\"fixed-case\">DNA</jats:styled-content> degradation. This leads to the formation of both oxidized purine and pyrimidine bases together with <jats:styled-content style=\"fixed-case\">DNA</jats:styled-content> single‐strand breaks at the exclusion, however, of direct double‐strand breaks. No evidence has been provided so far for the implication of delayed oxidative degradation pathways of cellular <jats:styled-content style=\"fixed-case\">DNA</jats:styled-content>. In that respect putative characteristic <jats:styled-content style=\"fixed-case\">UVA</jats:styled-content>‐induced <jats:styled-content style=\"fixed-case\">DNA</jats:styled-content> damage could include single and more complex lesions arising from one‐electron oxidation of the guanine base together with aldehyde adducts to amino‐substituted nucleobases.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825894332986752","@type":"Researcher","foaf:name":[{"@value":"Jean Cadet"}],"jpcoar:affiliationName":[{"@value":"University Grenoble Alpes INAC Grenoble France"},{"@value":"CEA INAC Grenoble France"},{"@value":"Département de Médecine Nucléaire et Radiobiologie Faculté de Médecine et des Sciences de la Santé Université de Sherbrooke Sherbrooke QC Canada"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894332986753","@type":"Researcher","foaf:name":[{"@value":"Thierry Douki"}],"jpcoar:affiliationName":[{"@value":"University Grenoble Alpes INAC/SCIB Grenoble France"},{"@value":"CEA INAC/SCIB Grenoble France"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016868851897216","@type":"Researcher","foaf:name":[{"@value":"Jean‐Luc Ravanat"}],"jpcoar:affiliationName":[{"@value":"University Grenoble Alpes INAC/SCIB Grenoble France"},{"@value":"CEA INAC/SCIB Grenoble France"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00318655"},{"@type":"EISSN","@value":"17511097"}],"prism:publicationName":[{"@value":"Photochemistry and 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