{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894409455104.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1111/j.1528-1167.2012.03633.x"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1528-1167.2012.03633.x"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1528-1167.2012.03633.x"}}],"dc:title":[{"@value":"Long‐term seizure outcome after resective surgery in patients evaluated with intracranial electrodes"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Summary</jats:title><jats:p><jats:bold>Purpose: </jats:bold> Despite advances in “noninvasive” localization techniques, many patients with medically intractable epilepsy require the placement of subdural (subdural grid electrode, SDE) and/or depth electrodes for the identification and definition of extent of the epileptic region. This study investigates the trends in longitudinal seizure outcome and its predictors in this group.</jats:p><jats:p><jats:bold>Methods: </jats:bold> We reviewed the medical records, and electroencephalography (EEG) data of 414 consecutive patients who underwent intracranial electrode placement (SDE and/or depth electrodes) at Cleveland Clinic Epilepsy Center between 1998 and 2008. A favorable outcome was defined as complete seizure freedom, discounting any auras or seizures that occurred within the first postoperative week. Survival curves were constructed, and Cox proportional hazard modeling was used to identify outcome predictors.</jats:p><jats:p><jats:bold>Key Findings: </jats:bold> The estimated probability of complete seizure freedom was 61% (95% confidence interval [CI] 58–64%) at one postoperative year, 47% (95% CI 44–50%) at 3 years, 42% (95% CI 39–45%) at 5 years, and 33% (95% CI 28–38%) at 10 years. Half of all seizure recurrences occurred within the first two postoperative months. Subsequently, the rate of seizure freedom declined by 4–5% every 2–3 years. After multivariate analysis, two independent predictors of seizure recurrence were identified: (1) prior resective surgery (p ≤ 0.002), mostly in patients with temporal lobe resections, and (2) sublobar or multilobar resection (p ≤ 0.02), mostly in patients following frontal lobe resections.</jats:p><jats:p><jats:bold>Significance: </jats:bold> Favorable seizure outcomes are possible in the complex epilepsy population requiring invasive EEG studies. We propose that mislocalization of the epileptogenic zone or its incomplete resection account for early postoperative recurrences, whereas epileptogenesis may lead to later relapses.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825894409455106","@type":"Researcher","foaf:name":[{"@value":"Juan C. Bulacio"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894409455111","@type":"Researcher","foaf:name":[{"@value":"Lara Jehi"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894409455110","@type":"Researcher","foaf:name":[{"@value":"Chong Wong"}]},{"@id":"https://cir.nii.ac.jp/crid/1380016868552191616","@type":"Researcher","foaf:name":[{"@value":"Jorge Gonzalez‐Martinez"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894409455105","@type":"Researcher","foaf:name":[{"@value":"Prakash Kotagal"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894409455109","@type":"Researcher","foaf:name":[{"@value":"Dileep Nair"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894409455104","@type":"Researcher","foaf:name":[{"@value":"Imad Najm"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894409455108","@type":"Researcher","foaf:name":[{"@value":"William Bingaman"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00139580"},{"@type":"EISSN","@value":"15281167"}],"prism:publicationName":[{"@value":"Epilepsia"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2012-08-20","prism:volume":"53","prism:number":"10","prism:startingPage":"1722","prism:endingPage":"1730"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1528-1167.2012.03633.x"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1528-1167.2012.03633.x"}],"createdAt":"2012-08-20","modifiedAt":"2023-10-30","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360580232424577024","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Clinical significance of ictal magnetoencephalography in patients undergoing epilepsy surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1360853567501940480","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Single-Institutional Experience of Chronic Intracranial Electroencephalography Based on the Combined Usage of Subdural and Depth Electrodes"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204410025472","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"てんかんの診断と外科治療の適応と課題"},{"@language":"en","@value":"Diagnosis, Clinical Indication, and Pending Problems in Surgical Treatment for Intractable Epilepsy"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205057653120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Long-Term Seizure Outcome Following Resective Surgery for Epilepsy: To be or Not to be Completely Cured?"}]},{"@id":"https://cir.nii.ac.jp/crid/1390589375730291072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Transition from Subdural Electrocorticography to Stereo-electroencephalography in Presurgical Evaluation of Epilepsy: Single-institutional Experience"}]},{"@id":"https://cir.nii.ac.jp/crid/1390855809731181952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Stereo-electroencephalography (SEEG) : The New Frontier in Localization of Epileptic Foci"},{"@language":"ja","@value":"てんかん焦点診断の最前線"},{"@value":"てんかん焦点診断の最前線 : Stereo-electroencephalography (SEEG)"},{"@language":"ja-Kana","@value":"テンカン ショウテン シンダン ノ サイゼンセン : Stereo-electroencephalography (SEEG)"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1111/j.1528-1167.2012.03633.x"},{"@type":"CROSSREF","@value":"10.7887/jcns.31.426_references_DOI_Q7vxV803MNRU1E6howlqoT4HC6t"},{"@type":"CROSSREF","@value":"10.2176/nmc.oa2013-0065_references_DOI_Q7vxV803MNRU1E6howlqoT4HC6t"},{"@type":"CROSSREF","@value":"10.1016/j.clinph.2022.10.005_references_DOI_Q7vxV803MNRU1E6howlqoT4HC6t"},{"@type":"CROSSREF","@value":"10.2176/jns-nmc.2025-0304_references_DOI_Q7vxV803MNRU1E6howlqoT4HC6t"},{"@type":"CROSSREF","@value":"10.3390/brainsci11030307_references_DOI_Q7vxV803MNRU1E6howlqoT4HC6t"},{"@type":"CROSSREF","@value":"10.7887/jcns.26.856_references_DOI_Q7vxV803MNRU1E6howlqoT4HC6t"}]}