{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894484574848.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3762/bjoc.13.262"}},{"identifier":{"@type":"URI","@value":"https://www.beilstein-journals.org/bjoc/articles/13/262"}},{"identifier":{"@type":"URI","@value":"https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-13-262.pdf"}},{"identifier":{"@type":"URI","@value":"http://www.beilstein-journals.org/bjoc/content/13/1/262"}}],"dc:title":[{"@value":"Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Monofluoroalkenes are fluorinated motifs that can be used to replace amide bonds. In order to be incorporated into peptides, it is normally necessary to first synthesize a dipeptide where the amide bond has been replaced with a monofluoroalkene. In that context, this review will present the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres described since 2007. Some applications of those compounds will also be presented.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825894484574848","@type":"Researcher","foaf:name":[{"@value":"Myriam Drouin"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894484574849","@type":"Researcher","foaf:name":[{"@value":"Jean-François Paquin"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"18605397"}],"prism:publicationName":[{"@value":"Beilstein Journal of Organic Chemistry"}],"dc:publisher":[{"@value":"Beilstein Institut"}],"prism:publicationDate":"2017-12-12","prism:volume":"13","prism:startingPage":"2637","prism:endingPage":"2658"},"reviewed":"false","dc:rights":["http://creativecommons.org/licenses/by/4.0","http://creativecommons.org/licenses/by/4.0","http://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.beilstein-journals.org/bjoc/articles/13/262"},{"@id":"https://www.beilstein-journals.org/bjoc/content/pdf/1860-5397-13-262.pdf"},{"@id":"http://www.beilstein-journals.org/bjoc/content/13/1/262"}],"createdAt":"2017-12-12","modifiedAt":"2021-06-23","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050585803064509056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Synthesis of Monofluoroalkene-Based Dipeptide Bioisosteres via Regioselective Ring Opening of 1,1-Difluorocyclopropanes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360005514495657856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Catalytic Enantioselective Synthesis of Allylic Boronates Bearing a Trisubstituted Alkenyl Fluoride and Related Derivatives"}]},{"@id":"https://cir.nii.ac.jp/crid/1360009142920374144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Convergent Synthesis of Fluoroalkenes Using a Dual-Reactive Unit"}]},{"@id":"https://cir.nii.ac.jp/crid/2051996266988242944","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Catalytic enantioselective allylic C-F bond functionalization"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.3762/bjoc.13.262"},{"@type":"CROSSREF","@value":"10.1002/anie.201906283_references_DOI_ZbQE9bxlZKtJ0Olm9H2AaV1o8Sm"},{"@type":"CROSSREF","@value":"10.1021/acs.joc.0c02474_references_DOI_ZbQE9bxlZKtJ0Olm9H2AaV1o8Sm"},{"@type":"CROSSREF","@value":"10.1246/cl.200826_references_DOI_ZbQE9bxlZKtJ0Olm9H2AaV1o8Sm"},{"@type":"CROSSREF","@value":"10.1055/a-2509-5342_references_DOI_ZbQE9bxlZKtJ0Olm9H2AaV1o8Sm"}]}