{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894539842048.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/circulationaha.113.004777"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.113.004777"}}],"dc:title":[{"@value":"Warfarin Use and the Risk for Stroke and Bleeding in Patients With Atrial Fibrillation Undergoing Dialysis"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n            <jats:title>Background—</jats:title>\n            <jats:p>Current observational studies on warfarin use and the risk for stroke and bleeding in patients with atrial fibrillation (AF) undergoing dialysis found conflicting results.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Methods and Results—</jats:title>\n            <jats:p>We conducted a population-based retrospective cohort study of patients aged ≥65 years admitted to a hospital with a primary or secondary diagnosis of AF, in Quebec and Ontario, Canada from 1998 to 2007. The AF cohort was grouped into dialysis (hemodialysis and peritoneal dialysis) and nondialysis patients and into warfarin and no-warfarin users according to the first prescription filled for warfarin within 30 days after AF hospital discharge. We determined the association between warfarin use and the risk for stroke and bleeding in dialysis and nondialysis patients. The cohort comprised 1626 dialysis patients and 204 210 nondialysis patients. Among dialysis patients, 46% (756/1626) patients were prescribed warfarin. Among dialysis patients, warfarin users had more congestive heart failure and diabetes mellitus, but fewer prior bleeding events in comparison with the no-warfarin users. Among dialysis patients, warfarin use, in comparison with no-warfarin use, was not associated with a lower risk for stroke (adjusted hazard ratio, 1.14; 95% confidence interval, 0.78–1.67) but was associated with a 44% higher risk for bleeding (adjusted hazard ratio, 1.44; 95% confidence interval, 1.13–1.85) after adjusting for potential confounders. Propensity score–adjusted analyses yielded similar results.</jats:p>\n          </jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions—</jats:title>\n            <jats:p>Our results suggest that warfarin use is not beneficial in reducing stroke risk, but it is associated with a higher bleeding risk in patients with AF undergoing dialysis.</jats:p>\n          </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825894539842177","@type":"Researcher","foaf:name":[{"@value":"Mitesh Shah"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842179","@type":"Researcher","foaf:name":[{"@value":"Meytal Avgil Tsadok"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842184","@type":"Researcher","foaf:name":[{"@value":"Cynthia A. Jackevicius"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842180","@type":"Researcher","foaf:name":[{"@value":"Vidal Essebag"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842181","@type":"Researcher","foaf:name":[{"@value":"Mark J. Eisenberg"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842048","@type":"Researcher","foaf:name":[{"@value":"Elham Rahme"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842178","@type":"Researcher","foaf:name":[{"@value":"Karin H. Humphries"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842182","@type":"Researcher","foaf:name":[{"@value":"Jack V. Tu"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842183","@type":"Researcher","foaf:name":[{"@value":"Hassan Behlouli"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842176","@type":"Researcher","foaf:name":[{"@value":"Helen Guo"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894539842049","@type":"Researcher","foaf:name":[{"@value":"Louise Pilote"}],"jpcoar:affiliationName":[{"@value":"From the Divisions of Clinical Epidemiology and General Internal Medicine, McGill University Health Center, Montreal, Quebec, Canada (M.S., M.A.T., NE.R., H.B., L.P._; Department of Pharmacy Practice and Administration, College of Pharmacy, Western University of Health Sciences, Pomona, CA (C.A.J.); Division of Cardiology, McGill University Health Center, Montreal, Quebec, Canada (V.E.); Divisions of Cardiology and Clinical Epidemiology, Jewish General Hospital/McGill University, Montreal, Quebec,..."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00097322"},{"@type":"EISSN","@value":"15244539"}],"prism:publicationName":[{"@value":"Circulation"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2014-03-18","prism:volume":"129","prism:number":"11","prism:startingPage":"1196","prism:endingPage":"1203"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.113.004777"}],"createdAt":"2014-01-23","modifiedAt":"2024-05-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360567184519147776","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of creatinine clearance on outcomes in patients with non-valvular atrial fibrillation: a subanalysis of the J-RHYTHM Registry"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661339116672","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Impact of the Number of Anti-Thrombosis Agents in Hemodialysis Patients: BOREAS-HD2 Study"}]},{"@id":"https://cir.nii.ac.jp/crid/1360865816794278784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Current status of stroke in hemodialysis patients on a remote island"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204470889984","@type":"Article","resourceType":"レビュー論文(review article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"冠動脈バイパス術後心房細動の予防と治療"},{"@language":"en","@value":"The prevention and management of postoperative atrial fibrillation after coronary artery bypass surgery"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206449363072","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"III．認知機能障害，脳血管障害の予防を踏まえたCKD治療"},{"@language":"en","@value":"III. Management for Patients with Chronic Kidney Disease in Light of Preventing Cognitive Impairment and Cerebrovascular Disease"}]},{"@id":"https://cir.nii.ac.jp/crid/1390009483098839040","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Case of the Left Atrial Appendage Perforation with the WATCHMAN Device Implantation Rescued by an Open Heart Surgery"},{"@language":"ja","@value":"WATCHMAN 留置中に左心耳穿孔を来し，開胸手術を要した1症例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390010842621111808","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"透析患者の脳卒中と心房細動"},{"@language":"ja-Kana","@value":"トウセキ カンジャ ノ ノウソッチュウ ト シンボウ サイドウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679656380032","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"5. 心血管領域—血液透析患者の心房細動とワルファリン投与"},{"@value":"心血管領域 : 血液透析患者の心房細動とワルファリン投与"},{"@language":"ja-Kana","@value":"シンケッカン リョウイキ : ケツエキ トウセキ カンジャ ノ シンボウ サイドウ ト ワルファリン トウヨ"},{"@value":"5. 心血管領域&mdash;血液透析患者の心房細動とワルファリン投与"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679657046528","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"8. 心血管領域—血液透析患者の心房細動とワルファリン投与—"},{"@value":"8. 心血管領域&mdash;血液透析患者の心房細動とワルファリン投与&mdash;"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680252217088","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical Assessment of Warfarin Therapy in Patients with Maintenance Dialysis-Clinical Efficacy, Risks and Development of Calciphylaxis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282681425624960","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"3．CKDと脳血管疾患"},{"@language":"en","@value":"3. 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