{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894678663552.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.67.3.1248"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.67.3.1248"}},{"identifier":{"@type":"NAID","@value":"30016258129"}}],"dc:title":[{"@value":"The γ-Glutamyl Cycle: A Possible Transport System for Amino Acids"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Evidence is presented that rat kidney contains enzymes that catalyze the synthesis and utilization of glutathione; these reactions, which involve the uptake and release of amino acids from γ-glutamyl linkage, constitute a cyclical process which is termed „the γ-glutamyl cycle.” The γ-glutamyl cycle has properties that fulfill the requirements of an amino acid transport system. Thus, γ-glutamyl transpeptidase may function in translocation and γ-glutamylcysteine synthetase and glutathione synthetase may catalyze energy-requiring „recovery” steps in transport. These and other considerations suggest that glutathione serves a carrier function in amino acid transport.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380857595339859072","@type":"Researcher","foaf:name":[{"@value":"Marian Orlowski"}],"jpcoar:affiliationName":[{"@value":"DEPARTMENT OF BIOCHEMISTRY, CORNELL UNIVERSITY MEDICAL COLLEGE, NEW YORK, N.Y. 10021"}]},{"@id":"https://cir.nii.ac.jp/crid/1380857595339859073","@type":"Researcher","foaf:name":[{"@value":"Alton Meister"}],"jpcoar:affiliationName":[{"@value":"DEPARTMENT OF BIOCHEMISTRY, CORNELL UNIVERSITY MEDICAL COLLEGE, NEW YORK, N.Y. 10021"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"},{"@type":"NCID","@value":"AA10808769"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"1970-11","prism:volume":"67","prism:number":"3","prism:startingPage":"1248","prism:endingPage":"1255"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.67.3.1248"}],"createdAt":"2006-05-31","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285705044556800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A Novel Prodrug of a γ‐Glutamylcyclotransferase Inhibitor Suppresses Cancer Cell Proliferation in vitro and Inhibits Tumor Growth in a Xenograft Mouse Model of Prostate Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567186303727488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Gamma-Glutamylcyclotransferase: A Novel Target Molecule for Cancer Diagnosis and 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