{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894748575104.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/chem.200800035"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.200800035"}},{"identifier":{"@type":"URI","@value":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.200800035"}}],"dc:title":[{"@value":"New Mono‐ and Dimeric Members of the Secalonic Acid Family: Blennolides A–G Isolated from the Fungus <i>Blennoria</i> sp."}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Blennolides A–G (<jats:bold>2</jats:bold>–<jats:bold>8</jats:bold>), seven unusual chromanones, were isolated together with secalonic acid B (<jats:bold>1</jats:bold>) from <jats:italic>Blennoria</jats:italic> sp., an endophytic fungus from <jats:italic>Carpobrotus edulis</jats:italic>. This is the first reported isolation of the blennolides <jats:bold>2</jats:bold> and <jats:bold>3</jats:bold> (hemisecalonic acids B and E), the existence of which as the monomeric units of the dimeric secalonic acids had long been postulated. A compound of the proposed structure <jats:bold>4</jats:bold> (β‐diversonolic ester) will need to be revised, as its reported data do not fit those of the established structure of blennolide C (<jats:bold>4</jats:bold>). Other monomers, the blennolides D–F (<jats:bold>5</jats:bold>–<jats:bold>7</jats:bold>) seem to be derived from blennolides A (<jats:bold>2</jats:bold>) and B (<jats:bold>3</jats:bold>) by rearrangement of the hydroaromatic ring. The heterodimer <jats:bold>8</jats:bold>, composed of the monomeric blennolide A (<jats:bold>2</jats:bold>) and the rearranged 11‐dehydroxy derivative of blennolide E (<jats:bold>6</jats:bold>), extends the ergochrome family with an ergoxanthin type of skeleton. The structures of the new compounds were elucidated by detailed spectroscopic analysis and further confirmed by an X‐ray diffraction study of a single crystal of <jats:bold>2</jats:bold>. The absolute configurations were determined by TDDFT calculations of CD spectra, including the solid‐state CD/TDDFT approach. Preliminary studies showed strong antifungal and antibacterial activities of these compounds against <jats:italic>Microbotryum violaceum</jats:italic> and <jats:italic>Bacillus megaterium</jats:italic>, respectively. They were also active against the alga <jats:italic>Chlorella fusca</jats:italic> and the bacterium <jats:italic>Escherichia coli.</jats:italic></jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825894748574979","@type":"Researcher","foaf:name":[{"@value":"Wen Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894748574976","@type":"Researcher","foaf:name":[{"@value":"Karsten Krohn"}]},{"@id":"https://cir.nii.ac.jp/crid/1380298344061849216","@type":"Researcher","foaf:name":[{"@value":"Zia‐Ullah"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894748574985","@type":"Researcher","foaf:name":[{"@value":"Ulrich Flörke"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894748574981","@type":"Researcher","foaf:name":[{"@value":"Gennaro Pescitelli"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894748574978","@type":"Researcher","foaf:name":[{"@value":"Lorenzo Di Bari"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894748574984","@type":"Researcher","foaf:name":[{"@value":"Sándor Antus"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894748574980","@type":"Researcher","foaf:name":[{"@value":"Tibor Kurtán"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894748574986","@type":"Researcher","foaf:name":[{"@value":"Joachim Rheinheimer"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894748574982","@type":"Researcher","foaf:name":[{"@value":"Siegfried Draeger"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825894748574983","@type":"Researcher","foaf:name":[{"@value":"Barbara Schulz"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09476539"},{"@type":"EISSN","@value":"15213765"}],"prism:publicationName":[{"@value":"Chemistry – A European Journal"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2008-05-20","prism:volume":"14","prism:number":"16","prism:startingPage":"4913","prism:endingPage":"4923"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fchem.200800035"},{"@id":"https://chemistry-europe.onlinelibrary.wiley.com/doi/pdf/10.1002/chem.200800035"}],"createdAt":"2008-04-18","modifiedAt":"2025-10-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002216681956608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structures of the Dimeric and Monomeric Chromanones, Gonytolides A–C, Isolated from the Fungus <i>Gonytrichum</i> sp. and Their Promoting Activities of Innate Immune Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360002219105934592","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Palladium-catalyzed Asymmetric Allylic C–H Oxidation for the Formal Synthesis of Gonytolide C"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282442893184","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Asymmetric <i>Syn</i>-Selective Vinylogous Addition of Butenolides to Chromones via Al-Li-BINOL Catalysis"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707501649408","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"New dimeric and monomeric chromanones, gonytolides D–G, isolated from the fungus Gonytrichum sp."}]},{"@id":"https://cir.nii.ac.jp/crid/1360285708106698112","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Design and Synthesis of Structure-Simplified Derivatives of Gonytolide for the Promotion of Innate Immune Responses"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643760949760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Eumitrins F-H: three new xanthone dimers from the lichen\n            <i>Usnea baileyi</i>\n            and their biological activities"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643842896128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Structural Basis for Isomerization Reactions in Fungal Tetrahydroxanthone Biosynthesis and Diversification"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567182481258624","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Asperdichrome, an unusual dimer of tetrahydroxanthone through an ether bond, with protein tyrosine phosphatase 1B inhibitory activity, from the Okinawan freshwater Aspergillus sp. 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