{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894820082048.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.78.7.4515"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.78.7.4515"}},{"identifier":{"@type":"NAID","@value":"30016272324"}}],"dc:title":[{"@value":"Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin."}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>A murine monoclonal antibody (OKT9) raised against human leukemic cells binds to a wide variety of leukemia and tumor cell lines and to a minority of leukemia cells taken directly from patients. Fetal thymus and liver are strongly reactive as are some normal, immature hemopoietic cells and activated lymphocytes. Reactivity with OKT9 appears to correlate with proliferation status in both normal and malignant populations. Biochemical analysis indicates that this structure is a approximately equal to 180,000-dalton glycoprotein with two disulfide-bonded subunits of approximately equal to 90,000-daltons. Isolation of the transferrin receptor from a T-cell line (MOLT-4) indicates that it also has a dimeric approximately equal to 180,000-dalton structure. Radio-labeled transferrin bound to its receptors can be specifically precipitated by the monoclonal OKT9, although the latter does not bind transferrin itself, indicating that the antigenic structure defined by this antibody is likely to be the transferrin receptor.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004057856892288","@type":"Researcher","foaf:name":[{"@value":"R Sutherland"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013170413342082","@type":"Researcher","foaf:name":[{"@value":"D Delia"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013170413342084","@type":"Researcher","foaf:name":[{"@value":"C Schneider"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013170413342081","@type":"Researcher","foaf:name":[{"@value":"R Newman"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013170413342083","@type":"Researcher","foaf:name":[{"@value":"J Kemshead"}]},{"@id":"https://cir.nii.ac.jp/crid/1380013170413342080","@type":"Researcher","foaf:name":[{"@value":"M Greaves"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"1981-07","prism:volume":"78","prism:number":"7","prism:startingPage":"4515","prism:endingPage":"4519"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.78.7.4515"}],"createdAt":"2006-05-31","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050016029293646080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Low-temperature plasma as magic wand to differentiate between the good and the evil"}]},{"@id":"https://cir.nii.ac.jp/crid/1360004231169979008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A novel genotoxicity assay of carbon nanotubes using functional macrophage receptor with collagenous structure (MARCO)-expressing chicken B lymphocytes"}]},{"@id":"https://cir.nii.ac.jp/crid/1360017282217343488","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Phase 1 Clinical Trial of PPMX‐T003, a Novel Human Monoclonal Antibody Specific for Transferrin Receptor 1, to Evaluate Its Safety, Pharmacokinetics, and Pharmacodynamics"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283693947384576","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"A novel transferrin receptor-targeted hybrid peptide disintegrates cancer cell membrane to induce rapid killing of cancer cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694072547840","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Significance of PITX2 Overexpression in Human Colorectal Cancer"}]},{"@id":"https://cir.nii.ac.jp/crid/1360285707241897856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"DOPG small unilamellar vesicles function as nano-carriers targeting the clustered lectin-like oxidized LDL receptor (LOX-1) on the cell surface"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848660461268736","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Serum ferritin level is a prognostic marker in patients with peripheral T‐cell lymphoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001206530144384","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Electron microscopic study of proliferative activity of malignant tumor cells. Relationship between morphological changes of microvilli of tumor cells and localization of transferrin receptor."},{"@value":"悪性腫よう細胞の増殖能に関する電顕的研究　微じゅう毛様突起の形態学的変化とトランスフェリンレセプターの局在との関連について"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679617662080","@type":"Article","relationType":["isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"New targeting therapy of cancer."},{"@value":"癌細胞を標的とする新しい治療法"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679878614784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Possible activation of murine T lymphocyte through CD98 is independent of interleukin 2/interleukin 2 receptor system"}]},{"@id":"https://cir.nii.ac.jp/crid/2050588892112951168","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Environmental impact on carcinogenesis under BRCA1 haploinsufficiency"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.78.7.4515"},{"@type":"CIA","@value":"30016272324"},{"@type":"CROSSREF","@value":"10.1007/s00204-013-1084-7_references_DOI_7Rij6DEKFRqJ629NKXOCGEzQHoL"},{"@type":"CROSSREF","@value":"10.1002/cpdd.1216_references_DOI_7Rij6DEKFRqJ629NKXOCGEzQHoL"},{"@type":"CROSSREF","@value":"10.1186/1471-2407-11-359_references_DOI_7Rij6DEKFRqJ629NKXOCGEzQHoL"},{"@type":"CROSSREF","@value":"10.1245/s10434-011-1739-7_references_DOI_7Rij6DEKFRqJ629NKXOCGEzQHoL"},{"@type":"CROSSREF","@value":"10.2220/biomedres.27.61_references_DOI_7Rij6DEKFRqJ629NKXOCGEzQHoL"},{"@type":"CROSSREF","@value":"10.1186/s41021-023-00258-5_references_DOI_7Rij6DEKFRqJ629NKXOCGEzQHoL"},{"@type":"CROSSREF","@value":"10.1111/ijlh.12592_references_DOI_7Rij6DEKFRqJ629NKXOCGEzQHoL"},{"@type":"CROSSREF","@value":"10.1080/10715762.2023.2190860_references_DOI_7Rij6DEKFRqJ629NKXOCGEzQHoL"},{"@type":"CROSSREF","@value":"10.1016/j.jddst.2019.03.014_references_DOI_7Rij6DEKFRqJ629NKXOCGEzQHoL"}]}