{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825894976097536.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.0900089106"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.0900089106"}}],"dc:title":[{"@value":"Dysregulated gene expression networks in human acute myelogenous leukemia stem cells"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of LSC, we identified 3,005 differentially expressed genes. Using 2 independent analyses, we identified multiple pathways that are aberrantly regulated in leukemic stem cells compared with normal HSC. Several pathways, including Wnt signaling, MAP Kinase signaling, and Adherens Junction, are well known for their role in cancer development and stem cell biology. Other pathways have not been previously implicated in the regulation of cancer stem cell functions, including Ribosome and T Cell Receptor Signaling pathway. This study demonstrates that combining global gene expression analysis with detailed annotated pathway resources applied to highly enriched normal and malignant stem cell populations, can yield an understanding of the critical pathways regulating cancer stem cells.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380576149332443265","@type":"Researcher","foaf:name":[{"@value":"Ravindra Majeti"}],"jpcoar:affiliationName":[{"@value":"Institute for Stem Cell Biology and Regenerative Medicine and Department of Internal Medicine, Divisions of Hematology and Oncology, Stanford University, Palo Alto, CA 94304;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149332443270","@type":"Researcher","foaf:name":[{"@value":"Michael W. Becker"}],"jpcoar:affiliationName":[{"@value":"Division of Hematology/Oncology, University of Rochester, Rochester, NY 14627;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149332443393","@type":"Researcher","foaf:name":[{"@value":"Qiang Tian"}],"jpcoar:affiliationName":[{"@value":"Institute for Systems Biology, Seattle, WA 98103;"},{"@value":"Department of Medicine/Hematology, University of Washington School of Medicine, and the Institute for Stem Cell and Regenerative Medicine, Seattle, WA 98103;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149332443269","@type":"Researcher","foaf:name":[{"@value":"Tsung-Lu Michael Lee"}],"jpcoar:affiliationName":[{"@value":"Institute for Systems Biology, Seattle, WA 98103;"},{"@value":"Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan 70101, Taiwan; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149332443392","@type":"Researcher","foaf:name":[{"@value":"Xiaowei Yan"}],"jpcoar:affiliationName":[{"@value":"Institute for Systems Biology, Seattle, WA 98103;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149332443264","@type":"Researcher","foaf:name":[{"@value":"Rui Liu"}],"jpcoar:affiliationName":[{"@value":"University of Michigan School of Dentistry, Ann Arbor, MI 48109"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149332443266","@type":"Researcher","foaf:name":[{"@value":"Jung-Hsien Chiang"}],"jpcoar:affiliationName":[{"@value":"Institute for Systems Biology, Seattle, WA 98103;"},{"@value":"Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan 70101, Taiwan; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149332443394","@type":"Researcher","foaf:name":[{"@value":"Leroy Hood"}],"jpcoar:affiliationName":[{"@value":"Institute for Systems Biology, Seattle, WA 98103;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149332443267","@type":"Researcher","foaf:name":[{"@value":"Michael F. Clarke"}],"jpcoar:affiliationName":[{"@value":"Institute for Stem Cell Biology and Regenerative Medicine and Department of Internal Medicine, Divisions of Hematology and Oncology, Stanford University, Palo Alto, CA 94304;"}]},{"@id":"https://cir.nii.ac.jp/crid/1380576149332443268","@type":"Researcher","foaf:name":[{"@value":"Irving L. Weissman"}],"jpcoar:affiliationName":[{"@value":"Institute for Stem Cell Biology and Regenerative Medicine and Department of Internal Medicine, Divisions of Hematology and Oncology, Stanford University, Palo Alto, CA 94304;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"2009-03-03","prism:volume":"106","prism:number":"9","prism:startingPage":"3396","prism:endingPage":"3401"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.0900089106"}],"createdAt":"2009-02-14","modifiedAt":"2022-04-12","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360004236340243072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360283694449795072","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21Cdkn1a and Pbx1 in Hematopoietic Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565168404888704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Identification of Therapeutic Targets for Quiescent, Chemotherapy-Resistant Human Leukemia Stem Cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579812047138176","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1360579820396419456","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656450594688","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Internal tandem duplication of FLT3 deregulates proliferation and differentiation and confers resistance to the FLT3 inhibitor AC220 by Up-regulating RUNX1 expression in hematopoietic cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656970284032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"H2.0-like Homeobox Regulates Early Hematopoiesis and Promotes Acute Myeloid Leukemia"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.0900089106"},{"@type":"CROSSREF","@value":"10.1155/2011/946936_references_DOI_K5PsdlrVNi2F5n8Cox9kkzU5Zbb"},{"@type":"CROSSREF","@value":"10.1371/journal.pone.0158290_references_DOI_K5PsdlrVNi2F5n8Cox9kkzU5Zbb"},{"@type":"CROSSREF","@value":"10.1182/bloodadvances.2022008405_references_DOI_K5PsdlrVNi2F5n8Cox9kkzU5Zbb"},{"@type":"CROSSREF","@value":"10.1126/scitranslmed.3000349_references_DOI_K5PsdlrVNi2F5n8Cox9kkzU5Zbb"},{"@type":"CROSSREF","@value":"10.1038/s41556-022-00852-9_references_DOI_K5PsdlrVNi2F5n8Cox9kkzU5Zbb"},{"@type":"CROSSREF","@value":"10.1007/s12185-015-1908-8_references_DOI_K5PsdlrVNi2F5n8Cox9kkzU5Zbb"},{"@type":"CROSSREF","@value":"10.1016/j.ccr.2012.06.027_references_DOI_K5PsdlrVNi2F5n8Cox9kkzU5Zbb"}]}