{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895081821184.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1164/rccm.201507-1491oc"}},{"identifier":{"@type":"URI","@value":"https://academic.oup.com/ajrccm/article-pdf/194/4/450/67265453/ajrccm_194_4_450.pdf"}}],"dc:title":[{"@value":"Gut Microbiota Predict Pulmonary Infiltrates after Allogeneic Hematopoietic Cell Transplantation"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title>\n                  <jats:sec>\n                    <jats:title>Rationale</jats:title>\n                    <jats:p>Pulmonary complications (PCs) cause significant morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HCT). Shifts in gut microbiota have been linked to HCT outcomes; however, their effect on PCs is unknown.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives</jats:title>\n                    <jats:p>To investigate whether changes in gut microbiota are associated with PCs after HCT.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>A single-center observational study was performed on 94 patients who underwent HCT from 2009 to 2011 and who were previously enrolled in a protocol for 16S ribosomal RNA sequencing of fecal microbiota. The primary endpoint, PC, was defined by new abnormal parenchymal findings on chest imaging in the setting of respiratory signs and/or symptoms. Outcomes were collected up to 40 months after transplant. Clinical and microbiota risk factors for PCs and mortality were evaluated using survival analysis.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements and Main Results</jats:title>\n                    <jats:p>One hundred twelve PCs occurred in 66 (70.2%) subjects. A high comorbidity index (hazard ratio [HR], 2.30; 95% confidence interval [CI], 1.30–4.00; P = 0.004), fluoroquinolones (HR, 2.29, 95% CI, 1.32–3.98; P = 0.003), low baseline diversity (HR, 2.63; 95% CI, 1.22–5.32; P = 0.015), and γ-proteobacteria domination of fecal microbiota (HR, 2.64; 95% CI, 1.10–5.65; P = 0.031), which included common respiratory pathogens, predicted PCs. In separate analyses, low baseline diversity was associated with PCs that occurred preengraftment (HR, 6.30; 95% CI, 1.42–31.80; P = 0.016), whereas γ-proteobacteria domination predicted PCs postengraftment (HR, 3.68; 95% CI, 1.49–8.21; P = 0.006) and overall mortality (HR, 3.52; 95% CI, 1.28–9.21; P = 0.016). Postengraftment PCs were also independent predictors of death (HR, 2.50; 95% CI, 1.25–5.22; P = 0.009).</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions</jats:title>\n                    <jats:p>This is the first study to demonstrate prospective changes in gut microbiota associated with PCs after HCT. Postengraftment PCs and γ-proteobacteria domination were predictive of mortality. This suggests an adverse relationship between the graft and lung, which is perhaps mediated by bacterial composition in the gut. Further study is warranted.</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895081821184","@type":"Researcher","foaf:name":[{"@value":"Bianca Harris"}],"jpcoar:affiliationName":[{"@value":"Pulmonary Service"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895081821187","@type":"Researcher","foaf:name":[{"@value":"Sejal M. Morjaria"}],"jpcoar:affiliationName":[{"@value":"Infectious Diseases Service, and"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895081821189","@type":"Researcher","foaf:name":[{"@value":"Eric R. Littmann"}],"jpcoar:affiliationName":[{"@value":"Lucille Castori Center for Microbes, Inflammation and Cancer, Sloan Kettering Institute, New York, New York; and"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895081821188","@type":"Researcher","foaf:name":[{"@value":"Alexander I. Geyer"}],"jpcoar:affiliationName":[{"@value":"Pulmonary Service"},{"@value":"Department of Medicine, Weill Cornell Medical College, New York, New York"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895081821190","@type":"Researcher","foaf:name":[{"@value":"Diane E. Stover"}],"jpcoar:affiliationName":[{"@value":"Pulmonary Service"},{"@value":"Department of Medicine, Weill Cornell Medical College, New York, New York"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895081821313","@type":"Researcher","foaf:name":[{"@value":"Juliet N. Barker"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Weill Cornell Medical College, New York, New York"},{"@value":"Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895081821185","@type":"Researcher","foaf:name":[{"@value":"Sergio A. Giralt"}],"jpcoar:affiliationName":[{"@value":"Department of Medicine, Weill Cornell Medical College, New York, New York"},{"@value":"Bone Marrow Transplant Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895081821186","@type":"Researcher","foaf:name":[{"@value":"Ying Taur"}],"jpcoar:affiliationName":[{"@value":"Infectious Diseases Service, and"},{"@value":"Department of Medicine, Weill Cornell Medical College, New York, New York"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895081821312","@type":"Researcher","foaf:name":[{"@value":"Eric G. Pamer"}],"jpcoar:affiliationName":[{"@value":"Infectious Diseases Service, and"},{"@value":"Lucille Castori Center for Microbes, Inflammation and Cancer, Sloan Kettering Institute, New York, New York; and"},{"@value":"Department of Medicine, Weill Cornell Medical College, New York, New York"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"1073449X"},{"@type":"EISSN","@value":"15354970"}],"prism:publicationName":[{"@value":"American Journal of Respiratory and Critical Care Medicine"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2016-08","prism:volume":"194","prism:number":"4","prism:startingPage":"450","prism:endingPage":"463"},"reviewed":"false","dc:rights":["https://academic.oup.com/pages/standard-publication-reuse-rights"],"url":[{"@id":"https://academic.oup.com/ajrccm/article-pdf/194/4/450/67265453/ajrccm_194_4_450.pdf"}],"createdAt":"2016-02-17","modifiedAt":"2026-03-21","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360005518709902080","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Microbiota as Predictor of Mortality in Allogeneic Hematopoietic-Cell Transplantation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360568470437703424","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Pre‐ and post‐serial metagenomic analysis of gut microbiota as a prognostic factor in patients undergoing haematopoietic stem cell transplantation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1164/rccm.201507-1491oc"},{"@type":"CROSSREF","@value":"10.1056/nejmoa1900623_references_DOI_Pun4A0lsJAVxRuW07FKV0S8oQ6f"},{"@type":"CROSSREF","@value":"10.1111/bjh.16205_references_DOI_Pun4A0lsJAVxRuW07FKV0S8oQ6f"}]}