{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895093784576.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1073/pnas.87.20.7883"}},{"identifier":{"@type":"URI","@value":"https://pnas.org/doi/pdf/10.1073/pnas.87.20.7883"}}],"dc:title":[{"@value":"DNA mismatch repair in Xenopus egg extracts: repair efficiency and DNA repair synthesis for all single base-pair mismatches."}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>Repair of all 12 single base-pair mismatches by Xenopus egg extracts was measured by a physical assay with a sequence containing four overlapping restriction sites. The heteroduplex substrates, derivatives of M13 phage DNA, differed in sequence at the mismatch position only and permitted measurement of repair to both strands. The efficiency of repair varied about 4-fold between the most and least effectively repaired mismatches. Repair was most active with C/A and T/C mismatches but the efficiency varied depending on the orientation of the mismatch. Mismatch-specific DNA repair synthesis was also observed but the extent of repair was not always predictive of the extent of synthesis, suggesting the presence of different repair systems or different modes of mismatch recognition.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1380004236857154309","@type":"Researcher","foaf:name":[{"@value":"I Varlet"}],"jpcoar:affiliationName":[{"@value":"Institut Jacques Monod, Centre National de la Recherche Scientifique, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380579815920596865","@type":"Researcher","foaf:name":[{"@value":"M Radman"}],"jpcoar:affiliationName":[{"@value":"Institut Jacques Monod, Centre National de la Recherche Scientifique, Paris, France."}]},{"@id":"https://cir.nii.ac.jp/crid/1380579815920596864","@type":"Researcher","foaf:name":[{"@value":"P Brooks"}],"jpcoar:affiliationName":[{"@value":"Institut Jacques Monod, Centre National de la Recherche Scientifique, Paris, France."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00278424"},{"@type":"EISSN","@value":"10916490"}],"prism:publicationName":[{"@value":"Proceedings of the National Academy of Sciences"}],"dc:publisher":[{"@value":"Proceedings of the National Academy of Sciences"}],"prism:publicationDate":"1990-10","prism:volume":"87","prism:number":"20","prism:startingPage":"7883","prism:endingPage":"7887"},"reviewed":"false","url":[{"@id":"https://pnas.org/doi/pdf/10.1073/pnas.87.20.7883"}],"createdAt":"2006-05-31","modifiedAt":"2022-04-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848665471442048","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"MutSα maintains the mismatch repair capability by inhibiting PCNA unloading"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942136238464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Oligo swapping method for in vitro DNA repair substrate containing a single DNA lesion at a specific site"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1073/pnas.87.20.7883"},{"@type":"CROSSREF","@value":"10.1186/s41021-018-0112-5_references_DOI_6QNpmM688axwYljbk1V5GF8yww8"},{"@type":"CROSSREF","@value":"10.7554/elife.15155_references_DOI_6QNpmM688axwYljbk1V5GF8yww8"}]}