{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895101078144.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1146/annurev.genet.36.062802.091007"}},{"identifier":{"@type":"URI","@value":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.genet.36.062802.091007"}}],"dc:title":[{"@value":"Genetic Approaches to Molecular and Cellular Cognition: A Focus on LTP and Learning and Memory"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>▪ Abstract  Long-term potentiation (LTP) is the predominant experimental model for the synaptic plasticity mechanisms thought to underlie learning and memory. This review is focused on the contributions of genetics to the understanding of the role of LTP in learning and memory. These studies have used a combination of genetics, molecular biology, neurophysiology, and psychology to demonstrate that molecular mechanisms of synaptic plasticity are critical for learning and memory. Because of the large scope of this literature, we focus primarily on genetic studies of hippocampal-dependent learning. Altogether, these findings not only demonstrate a role for plasticity in learning, they also lay down the foundations for the new field of molecular and cellular cognition.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895101078144","@type":"Researcher","foaf:name":[{"@value":"Anna Matynia"}],"jpcoar:affiliationName":[{"@value":"Departments of Neurobiology, Psychiatry, and Psychology, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895101078017","@type":"Researcher","foaf:name":[{"@value":"Steven A. Kushner"}],"jpcoar:affiliationName":[{"@value":"Departments of Neurobiology, Psychiatry, and Psychology, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095;"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895101078016","@type":"Researcher","foaf:name":[{"@value":"Alcino J. Silva"}],"jpcoar:affiliationName":[{"@value":"Departments of Neurobiology, Psychiatry, and Psychology, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90095;"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00664197"},{"@type":"EISSN","@value":"15452948"},{"@type":"PISSN","@value":"http://id.crossref.org/issn/00664197"},{"@type":"PISSN","@value":"https://id.crossref.org/issn/00664197"}],"prism:publicationName":[{"@value":"Annual Review of Genetics"}],"dc:publisher":[{"@value":"Annual Reviews"}],"prism:publicationDate":"2002-12","prism:volume":"36","prism:number":"1","prism:startingPage":"687","prism:endingPage":"720"},"reviewed":"false","url":[{"@id":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.genet.36.062802.091007"}],"createdAt":"2002-11-12","modifiedAt":"2023-04-25","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360848659479512320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Recovery of upper-limb function due to enhanced use-dependent plasticity in chronic stroke patients"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680153400320","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Genetic Approaches to the Molecular/Neuronal Mechanisms Underlying Learning and Memory in the Mouse"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1146/annurev.genet.36.062802.091007"},{"@type":"CROSSREF","@value":"10.1254/jphs.cpj05002x_references_DOI_D696z2bpakDJeTAeH3SMsmHhJoU"},{"@type":"CROSSREF","@value":"10.1093/brain/awq193_references_DOI_D696z2bpakDJeTAeH3SMsmHhJoU"}]}