{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895161909120.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1093/carcin/4.12.1547"}},{"identifier":{"@type":"URI","@value":"http://academic.oup.com/carcin/article-pdf/4/12/1547/7518649/4-12-1547.pdf"}},{"identifier":{"@type":"PMID","@value":"6360404"}}],"dc:title":[{"@value":"Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolysate mutagens, and their direct mutagenicities towards <i>Salmonella typhimurium</i> TA98 and TA98NR"}],"description":[{"notation":[{"@value":"Hydroxyamino, nitroso and nitro derivatives of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) and 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), mutagens-carcinogens produced on pyrolysis of amino acids, were synthesized from Trp-P-2 and Glu-P-1. 3-Hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole (N-OH-Trp-P-2) and 2-hydroxyamino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (N-OH-Glu-P-1) were obtained with good yields by controlled catalytic reduction of 3-nitro-1-methyl-5H-pyrido[4,3-b]indole and 2-nitro-6-methyldipyrido[1,2-a:3',2'-d]imidazole. Subsequent oxidation of N-OH-Trp-P-2 and N-OH-Glu-P-1 with gamma-manganese dioxide yielded 3-nitroso-1-methyl-5H-pyrido[4,3-b]indole and 2-nitroso-6-methyldipyrido[1,2-a:3',2'-d]imidazole. All six synthesized compounds were mutagenic to Salmonella typhimurium TA98 without mammalian activation systems. The mutagenic activities of hydroxyamino and nitroso derivatives were identical for both S. typhimurium TA98 and TA98NR, the nitroreductase deficient strain. However, nitro derivatives were essentially mutagenic only towards S. typhimurium TA98."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895161909123","@type":"Researcher","foaf:name":[{"@value":"Kazuki Saito"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895161909121","@type":"Researcher","foaf:name":[{"@value":"Yasushi Yamazoe"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895161909120","@type":"Researcher","foaf:name":[{"@value":"Tetsuya Kamataki"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895161909122","@type":"Researcher","foaf:name":[{"@value":"Ryuichi Kato"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"01433334"},{"@type":"EISSN","@value":"14602180"}],"prism:publicationName":[{"@value":"Carcinogenesis"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"1983","prism:volume":"4","prism:number":"12","prism:startingPage":"1547","prism:endingPage":"1550"},"reviewed":"false","url":[{"@id":"http://academic.oup.com/carcin/article-pdf/4/12/1547/7518649/4-12-1547.pdf"}],"createdAt":"2007-01-05","modifiedAt":"2017-08-24","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Salmonella%20typhimurium","dc:title":"Salmonella typhimurium"},{"@id":"https://cir.nii.ac.jp/all?q=Mutagenicity%20Tests","dc:title":"Mutagenicity Tests"},{"@id":"https://cir.nii.ac.jp/all?q=Imidazoles","dc:title":"Imidazoles"},{"@id":"https://cir.nii.ac.jp/all?q=Hydroxylamines","dc:title":"Hydroxylamines"},{"@id":"https://cir.nii.ac.jp/all?q=Nitro%20Compounds","dc:title":"Nitro Compounds"},{"@id":"https://cir.nii.ac.jp/all?q=Structure-Activity%20Relationship","dc:title":"Structure-Activity Relationship"},{"@id":"https://cir.nii.ac.jp/all?q=Mutation","dc:title":"Mutation"},{"@id":"https://cir.nii.ac.jp/all?q=Indicators%20and%20Reagents","dc:title":"Indicators and Reagents"},{"@id":"https://cir.nii.ac.jp/all?q=Carbolines","dc:title":"Carbolines"},{"@id":"https://cir.nii.ac.jp/all?q=Mutagens","dc:title":"Mutagens"},{"@id":"https://cir.nii.ac.jp/all?q=Nitroso%20Compounds","dc:title":"Nitroso Compounds"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001205258070912","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Copper Phthalocyanine Sulfonate-mediated Oxidative Degradation of 3-Hydroxyamino-1-methyl-5H-pyrido [4,3-b]indole [Trp-P-2(NHOH)], a Direct-acting Mutagen Derived from Trp-P-2 by Metabolic Activation"},{"@value":"Copper phthalocyanine sulfonate-mediated oxidative degradation of 3-hydroxyamino-1-methyl-5H-pyrido〔4,3-b〕indole 〔Trp-P-2(NHOH)〕, a direct-acting mutagen derived from Trp-P-2 by metabolic activation"}]},{"@id":"https://cir.nii.ac.jp/crid/2050025942153711616","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antimutagenic, anti-inflammatory, and antioxidative activities of the juice of Vitis ficifolia var. Ganebu, a woody vine in the grape family, known as Ryukyu-ganebu in Japan"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1093/carcin/4.12.1547"},{"@type":"OPENAIRE","@value":"doi_dedup___::98ae62c7d430a4ceb59142cf36fa0f9a"},{"@type":"CROSSREF","@value":"10.3123/jemsge.31.64_references_DOI_1paOSFXdUsfXKkTM07cP00E9WY3"},{"@type":"CROSSREF","@value":"10.1186/s41021-021-00225-y_references_DOI_1paOSFXdUsfXKkTM07cP00E9WY3"}]}