Rapid Coupling of Methyl Iodide with Aryltributylstannanes Mediated by Palladium(0) Complexes: A General Protocol for the Synthesis of <sup>11</sup>CH<sub>3</sub>‐Labeled PET Tracers

DOI Web Site Web Site 被引用文献13件

書誌事項

公開日
1997-12
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1002/chem.19970031219
公開者
Wiley

この論文をさがす

説明

<jats:title>Abstract</jats:title><jats:p>The reaction of methyl iodide and (excess) aryltributylstannane to give a methylarene has been studied with the focus on the realization of rapid coupling for incorporation of short‐lived radionuclides into bioactive organic compounds. The coupling of methyl iodide with tributylphenylstannane (40 equiv) is accomplished in >90% yield within 5 min at 60°C with a tri‐<jats:italic>o</jats:italic>‐tolylphosphine‐bound, coordinatively unsaturated Pd<jats:sup>0</jats:sup> complex together with a Cu<jats:sup>I</jats:sup> salt and K<jats:sub>2</jats:sub>CO<jats:sub>3</jats:sub> in DMF. This protocol is applicable to a variety of homo‐ and heteroaromatic tin compounds, to give the corresponding methylated derivatives. The effects of the tri‐<jats:italic>o</jats:italic>‐tolylphosphine ligand, a Cu(I) salt, and DMF are discussed. This new protocol provides a firm chemical basis for the synthesis of <jats:sup>11</jats:sup>CH<jats:sub>3</jats:sub>‐incorporated PET tracers.</jats:p>

収録刊行物

被引用文献 (13)*注記

もっと見る

問題の指摘

ページトップへ