{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895244696192.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/lary.23912"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Flary.23912"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/lary.23912"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/lary.23912"}}],"dc:title":[{"@value":"Survival outcomes in acute invasive fungal sinusitis: A systematic review and quantitative synthesis of published evidence"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:sec>\n                    <jats:title>Objectives/Hypothesis</jats:title>\n                    <jats:p>Acute invasive fungal sinusitis (AIFS) is an aggressive and often fatal infection. Despite improvements in medical and surgical therapy, survival remains limited and the factors that contribute to patient outcomes remain poorly understood. The current study systematically reviews and quantitatively synthesizes the published literature to characterize prognostic factors associated with survival.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design</jats:title>\n                    <jats:p>Systematic review.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>Fifty‐two studies comprising a total of 807 patients met inclusion criteria and were used for analysis of treatment, presentation, and outcomes. Univariate and multivariate logistic regression was used to identify prognostic factors.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>All studies were classified as level 4 evidence, as per definitions provided by the Oxford Center for Evidence‐Based Medicine. The most common presenting symptoms of patients with AIFS were facial swelling (64.5%), fever (62.9%), and nasal congestion (52.2%). Most patients were treated with a combination of intravenous antifungal medication and surgery. The overall survival rate was 49.7%. On univariate analysis, poor prognosis was associated with renal/liver failure, altered mental status, and intracranial extension. Patients who were diabetic, had surgery, or received liposomal amphotericin B had an improved chance of survival. On multivariate analysis, advanced age and intracranial involvement were identified as independent negative prognostic factors. Positive prognostic factors again included diabetes and surgical resection.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions</jats:title>\n                    <jats:p>The overall mortality of patients with AIFS remains high, with only half of the patients surviving. Diabetic patients appear to have a better overall survival than patients with other comorbidities. Patients who have intracranial involvement, or who do not receive surgery as part of their therapy, have a poor prognosis.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Level of Evidence</jats:title>\n                    <jats:p>N/A.</jats:p>\n                  </jats:sec>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895244696193","@type":"Researcher","foaf:name":[{"@value":"Justin H. Turner"}],"jpcoar:affiliationName":[{"@value":"Department of Otolaryngology–Head and Neck Surgery Vanderbilt University School of Medicine Nashville Tennessee U.S.A"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895244696195","@type":"Researcher","foaf:name":[{"@value":"Ethan Soudry"}],"jpcoar:affiliationName":[{"@value":"the Department of Otolaryngology–Head and Neck Surgery Stanford University School of Medicine Stanford California U.S.A."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895244696192","@type":"Researcher","foaf:name":[{"@value":"Jayakar V. Nayak"}],"jpcoar:affiliationName":[{"@value":"the Department of Otolaryngology–Head and Neck Surgery Stanford University School of Medicine Stanford California U.S.A."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895244696194","@type":"Researcher","foaf:name":[{"@value":"Peter H. Hwang"}],"jpcoar:affiliationName":[{"@value":"the Department of Otolaryngology–Head and Neck Surgery Stanford University School of Medicine Stanford California U.S.A."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0023852X"},{"@type":"EISSN","@value":"15314995"}],"prism:publicationName":[{"@value":"The Laryngoscope"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2013-01-08","prism:volume":"123","prism:number":"5","prism:startingPage":"1112","prism:endingPage":"1118"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Flary.23912"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/lary.23912"},{"@id":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/lary.23912"}],"createdAt":"2013-01-08","modifiedAt":"2023-08-20","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1390001204736234368","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"明らかな基礎疾患を有さない慢性浸潤性副鼻腔真菌症の3例"},{"@language":"en","@value":"Three Cases of Chronic Invasive Fungal Sinusitis without Clear Underlying Condition"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205283112576","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"眼窩先端症候群を伴った浸潤型副鼻腔真菌症の2症例"},{"@language":"en","@value":"Two cases of invasive fungal sinusitis showing orbital apex syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1390008998107666432","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Invasive Fungal Rhinosinusitis that Exacerbated Rapidly after Maxillary Antrostomy during Myelosuppression by Chemotherapy for Malignant Lymphoma: A Case Report"},{"@language":"ja","@value":"悪性リンパ腫に対する化学療法骨髄抑制期の上顎洞開放後に急速に進行した浸潤型副鼻腔真菌症例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679714924928","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"浸潤型副鼻腔真菌症の臨床的特徴と予後"},{"@language":"en","@value":"Clinical Features and Prognosis of Invasive Fungal Rhinosinusitis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679988928128","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"副鼻腔真菌症の診断と治療"},{"@value":"第115回日本耳鼻咽喉科学会総会ランチョンセミナー 副鼻腔真菌症の診断と治療"},{"@language":"ja-Kana","@value":"ダイ115カイ ニホン ジビ インコウ カガクカイ ソウカイ ランチョンセミナー フクビコウ シンキンショウ ノ シンダン ト チリョウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680374745856","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"副鼻腔真菌症の病理診断と原因菌種の多様性"},{"@language":"en","@value":"Histopathological Diagnosis of Fungal Sinusitis and Variety of its Etiologic Fungus"},{"@language":"ja-Kana","@value":"フクビコウ シンキンショウ ノ ビョウリ シンダン ト ゲンイン キンシュ ノ タヨウセイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390292706091621376","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical Study of Invasive Fungal Rhinosinusitis of the Sphenoid Sinus with an Orbital Tip Lesion"},{"@language":"ja","@value":"眼窩尖端部病変を伴った蝶形骨洞原発の浸潤型副鼻腔真菌症4症例の検討"},{"@language":"ja-Kana","@value":"ガンカセンタンブ ビョウヘン オ トモナッタ チョウケイ ホネドウ ゲンパツ ノ シンジュンガタ フクビコウ シンキンショウ 4 ショウレイ ノ ケントウ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390301949907902720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Orbital apex syndrome secondary to acute invasive fungal rhinosinusitis diagnosed by transnasal endoscopic biopsy of the optic canal:A case report"}]},{"@id":"https://cir.nii.ac.jp/crid/1390307114937581184","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"ja","@value":"眼窩先端症候群をきたした急性浸潤型副鼻腔真菌症例"},{"@language":"en","@value":"A Case of Acute Invasive Fungal Infection of the Sphenoid Sinus Causing Orbital Apex Syndrome"},{"@language":"ja-Kana","@value":"ガンカセンタン ショウコウグン オ キタシタ キュウセイ シンジュンガタ フクビコウ シンキン ショウレイ"}]},{"@id":"https://cir.nii.ac.jp/crid/1390564238106913280","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A Case of Invasive Fungal Sinusitis Presenting an Excellent Clinical Course"},{"@language":"ja","@value":"良好な経過を辿った浸潤型副鼻腔真菌症例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390848250130058752","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Examination of invasive fungal sinusitis for the past 5 years"},{"@language":"ja","@value":"当科で過去5年間に経験した浸潤性副鼻腔真菌症例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390859758186715648","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Percutaneous Transluminal Angioplasty and Stenting for Progressive Intracranial Carotid Artery Stenosis Secondary to Invasive Sphenoid Sinus Aspergillosis: A Case 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sinusitis"},{"@language":"ja","@value":"浸潤型副鼻腔真菌症に脳膿瘍と真菌性動脈瘤破裂を併発した高齢者の1剖検例"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/lary.23912"},{"@type":"CROSSREF","@value":"10.5106/jjshns.30.35_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.5106/jjshns.25.325_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.7248/jjrhi.60.522_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.3950/jibiinkotokeibu.125.6_1014_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.2176/jns-nmc.2022-0387_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.3995/jstroke.11146_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.3314/mmj.17.018_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.7248/jjrhi.57.17_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.2152/jmi.71.310_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.5631/jibirin.119.95_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.7248/jjrhi.58.209_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.3950/jibiinkoka.118.629_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"},{"@type":"CROSSREF","@value":"10.7248/jjrhi.56.110_references_DOI_H9eR1b2X1CANBiaCxk88VsspSzo"}]}