{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895314844288.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1007/s10165-006-0502-6"}},{"identifier":{"@type":"URI","@value":"http://www.springerlink.com/index/pdf/10.1007/s10165-006-0502-6"}},{"identifier":{"@type":"PMID","@value":"17039308"}}],"dc:title":[{"@value":"Evaluation of Pneumocystis pneumonia infection risk factors in patients with connective tissue disease"}],"description":[{"notation":[{"@value":"We conducted a retrospective, clinical evaluation of connective tissue disease (CTD) patients who were tested for either sputum or bronchoalveolar lavage fluid Pneumocystis polymerase chain reaction (PC-PCR) and analyzed the risk factors that cause Pneumocystis pneumonia (PCP) susceptibility and fatality. PC-PCR was performed on 66 CTD patients who presented with symptoms, data, or radiological findings strongly suggesting respiratory infection. Patients with higher oral corticosteroid doses, use of oral methotrexate (MTX), bilateral lung findings, positive beta-D-glucan, and no prophylaxis use were more susceptible to PCP. They had significantly low immunoglobulin G and significantly high beta-D-glucan and lactate dehydrogenase. Survivors and nonsurvivors of PCP were also evaluated. Poor prognoses were observed with older age, elevated beta-D-glucan, rheumatoid arthritis (RA) patients using MTX, hypoxemia, bilateral lung findings, and mechanical ventilation use. Nonsurvivors had significantly lower lymphocytes, oxygen saturation, and significantly higher beta-D-glucan. In RA, poor prognoses were seen with those taking MTX. Disease duration, underlying pulmonary complications, and oral corticosteroid doses did not lead to poor prognoses in RA. Because PCP in CTD leads to abrupt onset of symptoms with poor survival rates, early diagnosis and initiation of treatment are critical, and it is essential for clinicians to recognize risk factors that predispose patients to PCP and its mortality."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895314844290","@type":"Researcher","foaf:name":[{"@value":"Noriko Iikuni"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895314844293","@type":"Researcher","foaf:name":[{"@value":"Mariko Kitahama"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895314844291","@type":"Researcher","foaf:name":[{"@value":"Shuji Ohta"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895314844292","@type":"Researcher","foaf:name":[{"@value":"Hiroshi Okamoto"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895314844288","@type":"Researcher","foaf:name":[{"@value":"Naoyuki Kamatani"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895314844289","@type":"Researcher","foaf:name":[{"@value":"Makoto Nishinarita"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"14397595"},{"@type":"EISSN","@value":"14397609"}],"prism:publicationName":[{"@value":"Modern Rheumatology"}],"dc:publisher":[{"@value":"Oxford University Press (OUP)"}],"prism:publicationDate":"2006-10","prism:volume":"16","prism:number":"5","prism:startingPage":"282","prism:endingPage":"288"},"reviewed":"false","url":[{"@id":"http://www.springerlink.com/index/pdf/10.1007/s10165-006-0502-6"}],"createdAt":"2006-10-12","modifiedAt":"2022-03-09","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Adult","dc:title":"Adult"},{"@id":"https://cir.nii.ac.jp/all?q=Aged,%2080%20and%20over","dc:title":"Aged, 80 and over"},{"@id":"https://cir.nii.ac.jp/all?q=Male","dc:title":"Male"},{"@id":"https://cir.nii.ac.jp/all?q=Pneumonia,%20Pneumocystis","dc:title":"Pneumonia, Pneumocystis"},{"@id":"https://cir.nii.ac.jp/all?q=Sputum","dc:title":"Sputum"},{"@id":"https://cir.nii.ac.jp/all?q=Middle%20Aged","dc:title":"Middle Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Prognosis","dc:title":"Prognosis"},{"@id":"https://cir.nii.ac.jp/all?q=Polymerase%20Chain%20Reaction","dc:title":"Polymerase Chain Reaction"},{"@id":"https://cir.nii.ac.jp/all?q=Methotrexate","dc:title":"Methotrexate"},{"@id":"https://cir.nii.ac.jp/all?q=Risk%20Factors","dc:title":"Risk Factors"},{"@id":"https://cir.nii.ac.jp/all?q=Antirheumatic%20Agents","dc:title":"Antirheumatic Agents"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=Female","dc:title":"Female"},{"@id":"https://cir.nii.ac.jp/all?q=Connective%20Tissue%20Diseases","dc:title":"Connective Tissue Diseases"},{"@id":"https://cir.nii.ac.jp/all?q=Bronchoalveolar%20Lavage%20Fluid","dc:title":"Bronchoalveolar Lavage Fluid"},{"@id":"https://cir.nii.ac.jp/all?q=Aged","dc:title":"Aged"},{"@id":"https://cir.nii.ac.jp/all?q=Retrospective%20Studies","dc:title":"Retrospective Studies"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050001202663101056","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Incidence and Risk Factors for Infections Requiring Hospitalization Including Pneumocystis Pneumonia in Japanese Patients with Rheumatoid Arthritis"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679847566720","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Clinical and Radiological Features of Pneumocystis Pneumonia in Patients with Rheumatoid Arthritis, in comparison with Methotrexate Pneumonitis and Pneumocystis Pneumonia in Acquired Immunodeficiency Syndrome: A Multicenter Study"},{"@value":"Clinical and radiographical features of Pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with methotrexate pneumonitis and Pneumocystis pneumonia in acquired immunodeficiency syndrome: a multicenter study"}]},{"@id":"https://cir.nii.ac.jp/crid/1390576966668689920","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Severe Pneumocystis Pneumonia Associated with Ulcerative Colitis"},{"@language":"ja","@value":"潰瘍性大腸炎治療中に発症した致死的なニューモシスチス肺炎の1例"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1007/s10165-006-0502-6"},{"@type":"OPENAIRE","@value":"doi_dedup___::50da328ae0587dce8b87fb290ae684e5"},{"@type":"CROSSREF","@value":"10.1155/2017/6730812_references_DOI_YZJp8HTXvqlQR3fV3rKm7OUEywm"},{"@type":"CROSSREF","@value":"10.11150/kansenshogakuzasshi.e22003_references_DOI_YZJp8HTXvqlQR3fV3rKm7OUEywm"},{"@type":"CROSSREF","@value":"10.2169/internalmedicine.47.0702_references_DOI_YZJp8HTXvqlQR3fV3rKm7OUEywm"}]}