{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895327336064.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1161/01.cir.0000013838.94747.64"}},{"identifier":{"@type":"URI","@value":"https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000013838.94747.64"}},{"identifier":{"@type":"NAID","@value":"30022667321"}}],"dc:title":[{"@value":"Inhalation of Fine Particulate Air Pollution and Ozone Causes Acute Arterial Vasoconstriction in Healthy Adults"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Background</jats:italic>\n                </jats:bold>\n                —\n              </jats:italic>\n            </jats:bold>\n            Fine particulate air pollution and ozone are associated with increased cardiovascular events. To help explain the mechanism behind these observations, we investigated the effect of air pollution exposure on vascular function.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Methods and Results</jats:italic>\n                </jats:bold>\n                —\n              </jats:italic>\n            </jats:bold>\n            Twenty-five healthy adults underwent a randomized, double-blind, crossover study comparing the vascular response to the 2-hour inhalation of ≈150 μg/m\n            <jats:sup>3</jats:sup>\n            of concentrated ambient fine particles (CAP) plus ozone (120 ppb) versus the response to the inhalation of filtered air. High-resolution vascular ultrasonography was used to measure alterations in brachial artery diameter, endothelial-dependent flow-mediated dilatation (FMD) and endothelial-independent nitroglycerin-mediated dilatation (NMD). Exposure to CAP plus ozone caused a significant brachial artery vasoconstriction compared with filtered air inhalation (−0.09±0.15 mm versus +0.01±0.18 mm,\n            <jats:italic>P</jats:italic>\n            =0.03). There were no significant differences in FMD (+0.29±4.11% versus −0.03±6.63%,\n            <jats:italic>P</jats:italic>\n            =0.88), NMD (+3.87±5.43% versus +3.46±7.92%,\n            <jats:italic>P</jats:italic>\n            =0.83), or blood pressure responses between exposures.\n          </jats:p>\n          <jats:p>\n            <jats:bold>\n              <jats:italic>\n                <jats:bold>\n                  <jats:italic>Conclusions</jats:italic>\n                </jats:bold>\n                —\n              </jats:italic>\n            </jats:bold>\n            Short-term inhalation of fine particulate air pollution and ozone at concentrations that occur in the urban environment causes acute conduit artery vasoconstriction.\n          </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895327336066","@type":"Researcher","foaf:name":[{"@value":"Robert D. Brook"}],"jpcoar:affiliationName":[{"@value":"From the University of Michigan, Ann Arbor (R.D.B., S.R.); the University of Toronto, Toronto, Canada (J.R.B., B.U., F.S.); Environment Canada, Toronto (J.R.B.); and Health Canada (R.V.), Ottawa, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895327336069","@type":"Researcher","foaf:name":[{"@value":"Jeffrey R. Brook"}],"jpcoar:affiliationName":[{"@value":"From the University of Michigan, Ann Arbor (R.D.B., S.R.); the University of Toronto, Toronto, Canada (J.R.B., B.U., F.S.); Environment Canada, Toronto (J.R.B.); and Health Canada (R.V.), Ottawa, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895327336067","@type":"Researcher","foaf:name":[{"@value":"Bruce Urch"}],"jpcoar:affiliationName":[{"@value":"From the University of Michigan, Ann Arbor (R.D.B., S.R.); the University of Toronto, Toronto, Canada (J.R.B., B.U., F.S.); Environment Canada, Toronto (J.R.B.); and Health Canada (R.V.), Ottawa, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895327336068","@type":"Researcher","foaf:name":[{"@value":"Renaud Vincent"}],"jpcoar:affiliationName":[{"@value":"From the University of Michigan, Ann Arbor (R.D.B., S.R.); the University of Toronto, Toronto, Canada (J.R.B., B.U., F.S.); Environment Canada, Toronto (J.R.B.); and Health Canada (R.V.), Ottawa, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895327336064","@type":"Researcher","foaf:name":[{"@value":"Sanjay Rajagopalan"}],"jpcoar:affiliationName":[{"@value":"From the University of Michigan, Ann Arbor (R.D.B., S.R.); the University of Toronto, Toronto, Canada (J.R.B., B.U., F.S.); Environment Canada, Toronto (J.R.B.); and Health Canada (R.V.), Ottawa, Canada."}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895327336065","@type":"Researcher","foaf:name":[{"@value":"Frances Silverman"}],"jpcoar:affiliationName":[{"@value":"From the University of Michigan, Ann Arbor (R.D.B., S.R.); the University of Toronto, Toronto, Canada (J.R.B., B.U., F.S.); Environment Canada, Toronto (J.R.B.); and Health Canada (R.V.), Ottawa, Canada."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00097322"},{"@type":"EISSN","@value":"15244539"}],"prism:publicationName":[{"@value":"Circulation"}],"dc:publisher":[{"@value":"Ovid Technologies (Wolters Kluwer Health)"}],"prism:publicationDate":"2002-04-02","prism:volume":"105","prism:number":"13","prism:startingPage":"1534","prism:endingPage":"1536"},"reviewed":"false","url":[{"@id":"https://www.ahajournals.org/doi/full/10.1161/01.CIR.0000013838.94747.64"}],"createdAt":"2002-07-28","modifiedAt":"2024-05-06","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285708095562496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Optimal Laser Wavelength for Femtosecond Ionization of Polycyclic Aromatic Hydrocarbons and Their Nitrated Compounds in Mass Spectrometry"}]},{"@id":"https://cir.nii.ac.jp/crid/1360294643824461440","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Homeostatic and endocrine responses as the basis for systemic therapy with medical gases"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204475522816","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Association Between PM10 and O3 Levels and Hospital Visits for Cardiovascular Diseases in Bangkok, Thailand"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001205103178240","@type":"Article","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effects of Fine Particulate Matter on Daily Mortality for Specific Heart Diseases in Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679234746496","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Size Distribution and Characteristics of Chemical Components in Ambient Particulate Matter"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679433349120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Acute Stroke Mortality and Air Pollution: New Evidence from Shanghai, China"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282680081878144","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Effect of Dust Storm Events on Daily Emergency Admissions for Cardiovascular Diseases"}]},{"@id":"https://cir.nii.ac.jp/crid/2051714791989557760","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Ozone augments interleukin-8 production induced by ambient particulate matter"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1161/01.cir.0000013838.94747.64"},{"@type":"CIA","@value":"30022667321"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-11-0894_references_DOI_Eb3RiFtFtuyJxRps3TwVebdjxFt"},{"@type":"CROSSREF","@value":"10.4103/2045-9912.318863_references_DOI_Eb3RiFtFtuyJxRps3TwVebdjxFt"},{"@type":"CROSSREF","@value":"10.1539/joh.45.321_references_DOI_Eb3RiFtFtuyJxRps3TwVebdjxFt"},{"@type":"CROSSREF","@value":"10.1253/circj.cj-08-1149_references_DOI_Eb3RiFtFtuyJxRps3TwVebdjxFt"},{"@type":"CROSSREF","@value":"10.1186/s41021-018-0102-7_references_DOI_Eb3RiFtFtuyJxRps3TwVebdjxFt"},{"@type":"CROSSREF","@value":"10.2188/jea.je20080047_references_DOI_Eb3RiFtFtuyJxRps3TwVebdjxFt"},{"@type":"CROSSREF","@value":"10.2116/analsci.21.89_references_DOI_Eb3RiFtFtuyJxRps3TwVebdjxFt"},{"@type":"CROSSREF","@value":"10.1021/acs.analchem.8b00125_references_DOI_Eb3RiFtFtuyJxRps3TwVebdjxFt"}]}