{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895347351040.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1002/mabi.200800248"}},{"identifier":{"@type":"URI","@value":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmabi.200800248"}},{"identifier":{"@type":"URI","@value":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/mabi.200800248"}}],"dc:title":[{"@value":"Stimuli‐Responsive Polymersomes as Nanocarriers for Drug and Gene Delivery"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Polymeric formulations (micelles, vesicles etc.) have emerged as versatile drug carriers due to their increased stability, site specificity, blood circulation resistance and thus overall potential therapeutic effects compared to liposomes. Furthermore, stimuli‐responsive systems have been developed whose properties change after applying certain external triggers. Polymersomes are mainly composed of amphiphilic block copolymers that are held together in water due to strong physical interactions between the insoluble hydrophobic blocks, thus forming a bilayer morphology or, in the case of triblock copolymers, a bilayer‐like morphology. Formation and destabilization of these assemblies is a consequence of external stimuli (temperature, pH, oxidation/reduction conditions etc.). This review focuses on recent developments concerning stimuli‐ responsive polymersomes made of amphiphilic block copolymers and their potential applications within the biomedical field.</jats:p><jats:p><jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/jpeg\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/mgra001.jpg\"><jats:alt-text>magnified image</jats:alt-text></jats:graphic></jats:boxed-text>\n</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895347351043","@type":"Researcher","foaf:name":[{"@value":"Ozana Onaca"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895347351042","@type":"Researcher","foaf:name":[{"@value":"Ramona Enea"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895347351041","@type":"Researcher","foaf:name":[{"@value":"David W. Hughes"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895347351040","@type":"Researcher","foaf:name":[{"@value":"Wolfgang Meier"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"16165187"},{"@type":"EISSN","@value":"16165195"}],"prism:publicationName":[{"@value":"Macromolecular Bioscience"}],"dc:publisher":[{"@value":"Wiley"}],"prism:publicationDate":"2009-02-03","prism:volume":"9","prism:number":"2","prism:startingPage":"129","prism:endingPage":"139"},"reviewed":"false","dc:rights":["http://onlinelibrary.wiley.com/termsAndConditions#vor","http://doi.wiley.com/10.1002/tdm_license_1.1","http://onlinelibrary.wiley.com/termsAndConditions#vor"],"url":[{"@id":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fmabi.200800248"},{"@id":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/mabi.200800248"}],"createdAt":"2008-12-23","modifiedAt":"2023-09-13","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360021391870314240","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"In vivo MR imaging for tumor-associated initial neovascularization by supramolecular contrast agents"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565164379432448","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation"}]},{"@id":"https://cir.nii.ac.jp/crid/1360565167406265600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Density-tunable conjugation of cyclic RGD ligands with polyion complex vesicles for the neovascular imaging of orthotopic glioblastomas"}]},{"@id":"https://cir.nii.ac.jp/crid/1360572092600469888","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Photo-reactive oligodeoxynucleotide-embedded nanovesicles (PROsomes) with switchable stability for efficient cellular uptake and gene knockdown"}]},{"@id":"https://cir.nii.ac.jp/crid/1360576118704204800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Thermoresponsive glycopolymer vesicles: in situ observation of morphological changes and triggered cargo release"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846639639398784","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Biodegradable Polymeric Assemblies for Biomedical Materials"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848656154777600","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Thermoreversible UCST-type phase behavior of comb-like poly(N-phenyl maleimide-co-n-octadecyl vinyl ether) in organic media"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848657184524032","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Dual and multiple stimuli-responsive platonic micelles bearing disaccharides"}]},{"@id":"https://cir.nii.ac.jp/crid/1361131417905483264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Bundling Process of Citrulline Polypeptides upon UCST-Type Phase Separation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361412892888936704","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Synthesis and Properties of Upper Critical Solution Temperature Responsive Nanogels"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1002/mabi.200800248"},{"@type":"CROSSREF","@value":"10.1016/j.colsurfb.2023.113525_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"},{"@type":"CROSSREF","@value":"10.1002/anie.201706964_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"},{"@type":"CROSSREF","@value":"10.1088/1468-6996/16/3/035004_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"},{"@type":"CROSSREF","@value":"10.1016/j.jcis.2018.09.044_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"},{"@type":"CROSSREF","@value":"10.1021/acs.langmuir.9b00849_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"},{"@type":"CROSSREF","@value":"10.1039/d0cc01750g_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"},{"@type":"CROSSREF","@value":"10.1038/s41428-021-00488-w_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"},{"@type":"CROSSREF","@value":"10.1007/12_2011_160_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"},{"@type":"CROSSREF","@value":"10.1007/s00396-011-2514-9_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"},{"@type":"CROSSREF","@value":"10.1021/acs.jpcb.0c00934_references_DOI_8I6ITtbbdJz8w73Ub6R4S40Hps9"}]}