{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895356222336.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1038/srep41340"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/srep41340.pdf"}},{"identifier":{"@type":"URI","@value":"https://www.nature.com/articles/srep41340"}}],"dc:title":[{"@value":"Cell Death Mechanisms in Tumoral and Non-Tumoral Human Cell Lines Triggered by Photodynamic Treatments: Apoptosis, Necrosis and Parthanatos"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:title>Abstract</jats:title><jats:p>Cell death triggered by photodynamic therapy can occur through different mechanisms: apoptosis, necrosis or autophagy. However, recent studies have demonstrated the existence of other mechanisms with characteristics of both necrosis and apoptosis. These new cell death pathways, collectively termed regulated necrosis, include a variety of processes triggered by different stimuli. In this study, we evaluated the cell death mechanism induced by photodynamic treatments with two photosensitizers, <jats:italic>meso</jats:italic>-tetrakis (4-carboxyphenyl) porphyrin sodium salt (Na-H<jats:sub>2</jats:sub>TCPP) and its zinc derivative Na-ZnTCPP, in two human breast epithelial cell lines, a non-tumoral (MCF-10A) and a tumoral one (SKBR-3). Viability assays showed that photodynamic treatments with both photosensitizers induced a reduction in cell viability in a concentration-dependent manner and no dark toxicity was observed. The cell death mechanisms triggered were evaluated by several assays and cell line-dependent results were found. Most SKBR-3 cells died by either necrosis or apoptosis. By contrast, in MCF-10A cells, necrotic cells and another cell population with characteristics of both necrosis and apoptosis were predominant. In this latter population, cell death was PARP-dependent and translocation of AIF to the nucleus was observed in some cells. These characteristics are related with parthanatos, being the first evidence of this type of regulated necrosis in the field of photodynamic therapy.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895356222338","@type":"Researcher","foaf:name":[{"@value":"J. Soriano"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895356222340","@type":"Researcher","foaf:name":[{"@value":"I. Mora-Espí"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895356222339","@type":"Researcher","foaf:name":[{"@value":"M. E. Alea-Reyes"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895356222337","@type":"Researcher","foaf:name":[{"@value":"L. Pérez-García"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895356222336","@type":"Researcher","foaf:name":[{"@value":"L. Barrios"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895356222341","@type":"Researcher","foaf:name":[{"@value":"E. Ibáñez"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895356222342","@type":"Researcher","foaf:name":[{"@value":"C. Nogués"}]}],"publication":{"publicationIdentifier":[{"@type":"EISSN","@value":"20452322"}],"prism:publicationName":[{"@value":"Scientific Reports"}],"dc:publisher":[{"@value":"Springer Science and Business Media LLC"}],"prism:publicationDate":"2017-01-23","prism:volume":"7","prism:number":"1","prism:startingPage":"41340"},"reviewed":"false","dc:rights":["https://creativecommons.org/licenses/by/4.0","https://creativecommons.org/licenses/by/4.0"],"url":[{"@id":"https://www.nature.com/articles/srep41340.pdf"},{"@id":"https://www.nature.com/articles/srep41340"}],"createdAt":"2017-01-23","modifiedAt":"2022-12-24","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360286993483409280","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The optimization of cancer photodynamic therapy by utilization of a pi-extended porphyrin-type photosensitizer in combination with MITO-Porter"}]},{"@id":"https://cir.nii.ac.jp/crid/1360567183075622656","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Photosensitized Protein-Damaging Activity, Cytotoxicity, and Antitumor Effects of P(V)porphyrins Using Long-Wavelength Visible Light through Electron Transfer"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694366637973632","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"pH-Dependent photodynamic activity of bis(6-methyl-3-pyridylmethoxy)P(V)tetrakis(p-methoxyphenyl)porphyrin"}]},{"@id":"https://cir.nii.ac.jp/crid/1361694367846828800","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Controlled Photodynamic Action of Axial Fluorinated DiethoxyP(V)tetrakis(<i>p</i>-methoxyphenyl)porphyrin through Self-Aggregation"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1038/srep41340"},{"@type":"CROSSREF","@value":"10.1021/acs.chemrestox.8b00059_references_DOI_NwwnlTqXhnYir4cQqOXBv8ax6QD"},{"@type":"CROSSREF","@value":"10.1039/c9cc08563g_references_DOI_NwwnlTqXhnYir4cQqOXBv8ax6QD"},{"@type":"CROSSREF","@value":"10.1016/j.cplett.2020.137315_references_DOI_NwwnlTqXhnYir4cQqOXBv8ax6QD"},{"@type":"CROSSREF","@value":"10.1021/acs.chemrestox.9b00172_references_DOI_NwwnlTqXhnYir4cQqOXBv8ax6QD"}]}