{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1362825895390614656.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1074/jbc.m403499200"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820774533?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021925820774533?httpAccept=text/plain"}},{"identifier":{"@type":"URI","@value":"https://syndication.highwire.org/content/doi/10.1074/jbc.M403499200"}},{"identifier":{"@type":"PMID","@value":"15159409"}}],"dc:title":[{"@value":"A Caspase-8-independent Signaling Pathway Activated by Fas Ligation Leads to Exposure of the Bak N Terminus"}],"description":[{"notation":[{"@value":"Bak is a pro-apoptotic member of the Bcl-2 family that is activated by apoptotic stimulation: its activation is characterized by conformational changes such as exposure of the N terminus and oligomerization. In death receptor-mediated apoptosis, the activation of Bak depends on activation of caspase-8. However, we found that exposure of the N terminus of Bak (but not oligomerization) can occur in the absence of active caspase-8. Although exposure of the N terminus of Bak without oligomerization is not sufficient to release cytochrome c from the mitochondria and commit cells to apoptosis, this change sensitizes the mitochondria to apoptotic signals (including Bid) and thus sensitizes cells to apoptotic death. Fas-induced, caspase-8-independent exposure of the N terminus of Bak is blocked by staurosporine, a pan protein kinase inhibitor. These results suggest that Fas stimulation not only activates caspase-8, but also a distinct signaling pathway involving protein kinase(s) to induce exposure of the N terminus of Bak."}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1382825895390614785","@type":"Researcher","foaf:name":[{"@value":"Lilin Zhang"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895390614784","@type":"Researcher","foaf:name":[{"@value":"Shigeomi Shimizu"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895390614656","@type":"Researcher","foaf:name":[{"@value":"Kazuhiro Sakamaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895390614786","@type":"Researcher","foaf:name":[{"@value":"Shin Yonehara"}]},{"@id":"https://cir.nii.ac.jp/crid/1382825895390614657","@type":"Researcher","foaf:name":[{"@value":"Yoshihide Tsujimoto"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219258"}],"prism:publicationName":[{"@value":"Journal of Biological Chemistry"}],"dc:publisher":[{"@value":"Elsevier BV"}],"prism:publicationDate":"2004-08","prism:volume":"279","prism:number":"32","prism:startingPage":"33865","prism:endingPage":"33874"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","dc:rights":["https://www.elsevier.com/tdm/userlicense/1.0/","http://creativecommons.org/licenses/by/4.0/"],"url":[{"@id":"https://api.elsevier.com/content/article/PII:S0021925820774533?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0021925820774533?httpAccept=text/plain"},{"@id":"https://syndication.highwire.org/content/doi/10.1074/jbc.M403499200"}],"createdAt":"2004-05-25","modifiedAt":"2023-04-28","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Conformation","dc:title":"Protein Conformation"},{"@id":"https://cir.nii.ac.jp/all?q=Recombinant%20Fusion%20Proteins","dc:title":"Recombinant Fusion Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Green%20Fluorescent%20Proteins","dc:title":"Green Fluorescent Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Apoptosis","dc:title":"Apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=Transfection","dc:title":"Transfection"},{"@id":"https://cir.nii.ac.jp/all?q=Jurkat%20Cells","dc:title":"Jurkat Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Humans","dc:title":"Humans"},{"@id":"https://cir.nii.ac.jp/all?q=fas%20Receptor","dc:title":"fas Receptor"},{"@id":"https://cir.nii.ac.jp/all?q=Enzyme%20Inhibitors","dc:title":"Enzyme Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Kinase%20Inhibitors","dc:title":"Protein Kinase Inhibitors"},{"@id":"https://cir.nii.ac.jp/all?q=Caspase%208","dc:title":"Caspase 8"},{"@id":"https://cir.nii.ac.jp/all?q=Antibodies,%20Monoclonal","dc:title":"Antibodies, Monoclonal"},{"@id":"https://cir.nii.ac.jp/all?q=Cytochromes%20c","dc:title":"Cytochromes 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